Conserved Protein Domain Family
ApoL

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pfam05461: ApoL 
Apolipoprotein L
Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.
Statistics
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PSSM-Id: 428480
Aligned: 32 rows
Threshold Bit Score: 343.853
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007503451 171 LSEDEAWERFFADSSSMREKATQLSETLYGLFGDKVLDDTNGqDGSLSDEDKIFLKEFPKKKMELEERIQDLHAIADQVD 250 gray short-tail...
Q9BWW9        51 VNLCQSWKINNLMSTVHSDEAGMLSYFL--FEELMRCDKDSMpDGNLSEEEKLFLSYFPLHKFELEQNIKELNTLADQVD 128 human
XP_005625974  55 LFDAKAWEMLVQRSGLDRDEANILYHML--MEELMQNKEASM-LENLSEEEKIFLFWFPLQKNNLKKNIRELHALADQVD 131 dog
2_pfamImport   1 LFHPEAWELMVERSGLDRDEANTLHHIL--MEELIRQKEVSM-PGNLLEEEKMFLLCFPLQKYKLEKSIKELHAVADQLD 77 
Q5U1W1        31 LTKDEAWKVFVAEAELSRDEEASLHEALKLLLKLPTWEDKVR-LQKELQDRKKFVEAFPQLKRKLQENIRKLRALADHLD 109 Norway rat
Q8VDU3        11 VAEDGVWQAFVSKAKLSRERAVALHKALRELTALLAIADRGR-LQKGLKGREKFLKVFPRLKAELVEHISQLHALADHAE 89  house mouse
Q5XIB6        11 LTAEGAWEEFVSKAKLPRDRAVALHKALRDLTALLAIAERGR-SRKGWKGKEKFVKAFPCLKADLEEHISQLYALADHAE 89  Norway rat
XP_013008670  33 LTDDVAWEIIVETTDLTRKEADAVREALTDLQADC---------DEDFQARKRFLNEFPNVKKEMQEHIAKLYALAERID 103 domestic guinea...
EHB14171      33 LTHSGAWEVFVEMAKLTREEADALREALNVCTADT---------DEDLRARERYLKEFSEMKMELQKQIAQLHALADRID 103 naked mole-rat
XP_012004181  36 LTEDKPWENFVTKANLSREEADGLREYLIKVQTVLAGEDQDRlLQKYQQEKERFLKEFPQVKQELKENIKKLRELADSVD 115 mouflon
XP_007503451 251 KTHKKCIITNVVAGSTSIISSIVTIMGLALAPVTAGGSLILSASGFGLGALAAITSLSSSVIERVGNLTAKERVSNHKGT 330 gray short-tail...
Q9BWW9       129 TTHELLTKTSLVASSSGAVSGVMNILGLALAPVTAGGSLMLSATGTGLGAAAAITNIVTNVLENRSNSAARDKASRLGPL 208 human
XP_005625974 132 AKHKMLTKTSLVASSSGTVSGVMSILGFALAPVTVGGSLMLSAAGLGLGVAAVATNTLTSILERNSNSAARDRASRLVPV 211 dog
2_pfamImport  78 ATHKMLTKTRLVASSSGTISGVLSLLGLALAPVTVEGSLMLSVAGLGLGAAAAATNALTSIFESRSN-AARDRASGLVPM 156
Q5U1W1       110 QVHKGCTISNVVTNSTSAASGVLSILGLALAPVTAGGSLLLSATGLGLGTVATVTGAATEIVEQTNKWLDEAEARRLLSD 189 Norway rat
Q8VDU3        90 KLHRGCTISNVVADSFSAASDILSLLGLFLAPVTAEGSLVLSATGLGLGVAATVTDVATSIVEETSRVLDEVEAA---PT 166 house mouse
Q5XIB6        90 ELHRGCTVSNMVADSFSVASDILNLFGLFLAPESAEGSLVLSAAGLGLGVAATVTNVATSIMKETSRVLDGVEAGHHGST 169 Norway rat
XP_013008670 104 KVHKGCTITNVVASTGGAVSGILTMLGFALAPVTAGGSLVLSATGMGLGTAAAVTGVSASIVDHSNKVSAQAEARQLLTS 183 domestic guinea...
EHB14171     104 RIHRNCTVSNMVSSSAGAASGVLTILGLALAPVTAGSSLLLSATGMGLGAVSAMTSAAAAIVEQSSVSSAKAEARCLVTN 183 naked mole-rat
XP_012004181 116 KVHRDCTISNVVASSTGIASGALSILGLFLAPFTAGLSLGLSAAGIGLGAASAVTGLSTMVVENVNTSSAESQASSL--- 192 mouflon
XP_007503451 331 ---KGQVAMVVLCKEAPQVVSVAQRCVslgnQVLEEINKNIRAFRLAKANTRLTTSAKTLMTTGSLSTRSARKVEKAFGG 407 gray short-tail...
Q9BWW9       209 -----TTSHEAFGGINWSEIEAAGFCVnkcvKAIQGI-KDLHAYQMAKSNSGFMAMVKNFVAKRHIPFWTARGVQRAFEG 282 human
XP_005625974 212 ---PAMTVHDSSEERGCSEISAALLCIdkcvRAFKNL-KELRAYQMAKANSGFMAKVNKFMAMGHIPFWRTGGLQRAVGA 287 dog
2_pfamImport 157 ---ETTMVYEALEGIRLPEISAAWSCVvrcvGLLKNV-KELRACQMAKASSGFMAKGNDFMDTRHVLFWRVGRLQTAVEG 232
Q5U1W1       190 tmdTLNTAL-VLGQKALKLSKKAYDVI----KQLKSLGQHIRAIRVARANPRLLADAKRLMTSGRLSAPRASQVQNAFEG 264 Norway rat
Q8VDU3       167 gthVLGEAGTSVDRIASKVPQATRDIT----RDLEALEQHMNALRLVRANPRLEEDARILATTGSISAQRAMQVRASLKG 242 house mouse
Q5XIB6       170 amdILEEAGTSVARIASEIPQATRDIT----RDLEALEQHMNALSLVRANPRLEEDARALINAGSIPAQRAKQVRASLKG 245 Norway rat
XP_013008670 184 rldTGKEVLQVVGQATPKVVAASKKCV----QTFQSIEKNLYALKVAQSNPRLLARANRFIKTGKISARSGKQVQKAFGG 259 domestic guinea...
EHB14171     184 skdTAKELAQSVGQVELDVVLKSVQGI----SVLKGMKKSIHALKLARADARLLANANRFTGTWKIPFRKGERVQKAFGG 259 naked mole-rat
XP_012004181 193 --------------NTDKVKCCLSDLY----QV-KDLRRHIHAIREARRNPQLVATAQSHIETWQLSDPAPQEVSTHFGG 253 mouflon
XP_007503451 408 TALAMTKGSRMMSAMTTGAFVLVDMITVIHDLNHLLEGAKAEMAGELREQAQELEGKLEELSQ 470 gray short-tailed opossum
Q9BWW9       283 TTLAMTNGAWVMGAAGAGFLLMKDMSSFLQSWKHLEDGARTETAEELRALAKKLEQELDRLTQ 345 human
XP_005625974 288 SVMPMTKVARLLGAAGAGLSLMQDLRSLQQSWTHLEEGAKAETAEELRAVAGALEQELDQLTQ 350 dog
2_pfamImport 233 SALSMTKGARLLGAAGTGFLLMQDVRSLLHSWKHLKEGTRAETAEELRTVAWKLEQELSQLTQ 295
Q5U1W1       265 TALAMTKKARIRGVATAGVFLAMDVYFLVRDSMDLCDGAKSESGNKLRALAQELEEKLKEVAQ 327 Norway rat
Q8VDU3       243 TPLAMSNEARIQRATAAGAALWSDVDSLVKESKHLYEGSASESAEALRKLARELEEKLEGLME 305 house mouse
Q5XIB6       246 TPLAMSKEDRIRSATTTGVTLLRDVGSLVNESKQLYEGSASESAAALRKLAQELEEKLGELMK 308 Norway rat
XP_013008670 260 TTLAMTKGTRLMGAATAGLFALVDVYSLVQDSVHLHNGAKTESAAELRQEAQVLEEKLEELTE 322 domestic guinea pig
EHB14171     260 TAQAMSKGARMMGAAVAAVFLLVDVYSLVQTSKHLQKGAKAESAEELRQQAQVLERKLEELIG 322 naked mole-rat
XP_012004181 254 TPLAMTRAARIGSGVLSGVFIGLDVYSLVKDAQDLQEGAKTASAENMRQKAQELEKKLEELTW 316 mouflon
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