Conserved Protein Domain Family
eIF_4EBP

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pfam05456: eIF_4EBP 
Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognized by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F.
Statistics
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PSSM-Id: 398880
Aligned: 43 rows
Threshold Bit Score: 116.984
Threshold Setting Gi: 328876322
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX81736      10 AaQPQGQAIP---RRILINDASQLPHDYSSTPNGTLYSTTPG---------GTKIIYDRNFLLQMRNSPVARTPPKNLPV 77  common water flea
EDS43555      10 A----AMTIPs--RKVLIHDASDLPDLYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLARTPPTNLNN 74  southern house ...
ETN61553      10 AcASITQAIPs--KRVLIHDASELPDLYSSTPGGTLYSTTPGasrpssggpSTRIVYERAFLMNLKNSPLARTPPNN--- 84  Anopheles darlingi
Q7PN41        10 AcASISQAIPs--KRVLIHDASELPDLYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLARTPPNN--- 75  Anopheles gambi...
Q17JZ5        10 Ac-SQTQAIPs--KRVLIHDASELPDLYSSTPGGTLYSTTPG---------GTRIVYERAFLMNLKNSPLARTPPSNLNN 77  yellow fever mo...
XP_002045320  10 A---ITQALPmitRKVVISDPIQMPEVYSSTPGGTLYSTTPG---------GTKLIYERAFMKNLRGSPLSQTPPSNVPS 77  Drosophila sech...
NP_001040409  10 A--THSQSIPs--RRVLITDPAQMPDVYSSTPGGTIYSTTPG---------GTRIVYERSFMLSLRQSPISQTPPQ--CA 74  domestic silkworm
EFA09088      10 V--TESKAIPt--KKVLINDPSELPSHYSSTPGGTLYSTTPG---------GTKIVYEKAFLMNLRNSPISKTPPSYG-- 74  red flour beetle
5_pfamImport   8 A--TMSQSIPs--KRILISDSSQLPIDYSTTPGGTLYSTTPG---------GTRIVYERSTLMFLRNSPLSQTPPN---- 70 
EGG24685       7 AaSTTSRAIPfnvSRQDMI-------NFSTSLGGTLYGTTPG---------GTKLVYDKNTLLQYRNSPLAKTPP----- 65  Cavenderia fasc...
EFX81736      78 ----------------IP-------GVTCDSPHKeksklingqknvtvqHKPVELPTVEIEKVEEKKQ----EEPQFEMD 130 common water flea
EDS43555      75 ----------------LPhni--lrNSPTANRQQ----------------QHVPQAKKQP-NAQPKFDe--hQE-QFDMD 116 southern house ...
ETN61553      85 ----------------VPlnllranGSPTGGASAkpl---------stlSLSKPNQQKPARNSPPKYDe--hQE-QFDMD 136 Anopheles darlingi
Q7PN41        76 ----------------VPmnl-lrtGVVSPNTKPm--------------TTLSVKQQKPARNSPPKYDe--hQE-QFDMD 121 Anopheles gambi...
Q17JZ5        78 ----------------LPhni--lrNGTTGVTSK-------------------PKPQQQPQNSPPKFDe--hQE-QFDMD 117 yellow fever mo...
XP_002045320  78 cllrgtprtpfrkcvpVPtel---------------------------------------vkQTKSLKi--eDQEQFQLD 116 Drosophila sech...
NP_001040409  75 ----------------LPaal--lkNPSSVPNVQ-------------------PASTQKPRSNSISFDe--sQE-TFSMD 114 domestic silkworm
EFA09088      75 ----------------IPenl--mrGKTNGSAPI-------------------RRFSPPTKNHSAKIEds-hDEHQFQID 116 red flour beetle
5_pfamImport  71 ----------------IPdcc--krGNDIKSNRE-------------------NGLRRNPLKKTHENDd--cNE-QFQID 110
EGG24685      66 ----------------PPemanmlnMINKSQSSPhph---------skpIHSNKQPAAASTSAEAKNTtkqnEDDIFEMD 120 Cavenderia fasc...
EFX81736     131 I 131 common water flea
EDS43555     117 L 117 southern house mosquito
ETN61553     137 L 137 Anopheles darlingi
Q7PN41       122 L 122 Anopheles gambiae str. PEST
Q17JZ5       118 L 118 yellow fever mosquito
XP_002045320 117 L 117 Drosophila sechellia
NP_001040409 115 L 115 domestic silkworm
EFA09088     117 I 117 red flour beetle
5_pfamImport 111 I 111
EGG24685         -     Cavenderia fasciculata
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