Conserved Protein Domain Family
Tmemb_9

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pfam05434: Tmemb_9 
TMEM9
This family contains several eukaryotic transmembrane proteins which are homologous to human transmembrane protein 9. The TMEM9 gene encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites and three conserved cys-rich domains in the N-terminus, but no known functional domains. The protein is highly conserved between species from Caenorhabditis elegans to man and belongs to a novel family of transmembrane proteins. The exact function of TMEM9 is unknown although it has been found to be widely expressed and localized to the late endosomes and lysosomes. Members of this family contain pfam03128 repeats in their N-terminal region.
Statistics
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PSSM-Id: 398868
Aligned: 17 rows
Threshold Bit Score: 151.755
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q21960       106 TKTNIEPS--HCKPSNIVKDQVs-nFVDETHMDaFLANCDCRYESRNTVLLKVVVIFVICVIAVLTGYMVFLMCLDPMLR 182 Caenorhabditis ...
Q9VNA4        88 NSSNSSSTt-ECVCAGALLPRL---DANGKELP-ICAECKCSHVARNTTLIKVVVIIVIWIISILVIYMLFLMCLDPLLN 162 fruit fly
XP_002000398  74 TSSNASSNshECTCAGALAPQL---DANGRELP-TCAKCKCSSVGRNSTLIKVVVIIVIWIISILVIYMLFLMCLDPLLN 149 Drosophila moja...
NP_001233064  44 YIANVLP---SNDCNGVSLPIIg--EVNNTKKE-LCPRCTCTYESRNTTTMKVVVLIVLCVISCLVMYMFFLLCLEPMIR 117 pea aphid
1_pfamImport   4 YTKNVLHE--YCNCLMVVLPNLngsNLTDVDIEpYCLRCGCKYEVRSTKTMQVVVYLFLVLLGVLLIYMVVMVIADPFIN 81 
Q6IQA1        55 YNQNVSLK--DCNCLHVVEPm----PVEGKDVEaYCLRCECKYEERSSGTIKCTIIIYLSILGLLLLYMVYLTLLEPILK 128 zebrafish
XP_016790996  44 YNQNVSQK--DCNCLHVVEPm----PVPGHDVEaYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIR 117 chimpanzee
EFX75498      52 YIENVPPN--KCDCTNVVLPRVg-dDIKGKEKE-FCPRCECKYESRNTTTIKVVVIIVIWIISLLVIYMLFLVCLDPLLN 127 common water flea
EEC04479      53 YIMNVPPR--RCNCEGAILPQAt--DIKGRESE-FCPRCMCRYERRNTTTIRVLVILIIWVISLLTVYMLFLMCLDPLLN 127 black-legged tick
XP_015787459  69 YIDTVPPL--KCNCDGFVLPQLt--NVSSKE---FCPLCECRFESRNTEIIRYVIIGVISIIFLLVAYMLVLALDSYMLW 141 two-spotted spi...
Q21960       183 ---KKr-LSISYQQHNDEMednifaaaPSTDDESSSASNsmd-tqGTTRAR-SNVLGRVEAEQNRWMKKVEEQRRNIFED 256 Caenorhabditis ...
Q9VNA4       163 ---KR--VKANYQEHTNED--------DEPTPPLPAVNN------QELSAR-ANVLNRVGHQQDKWKRQVREQRRHIYDR 222 fruit fly
XP_002000398 150 ---KRv-KTNNYQEHTNED--------DEPAPPLPASANn-----QELSAR-ANVLNRVGHQQDKWKRQVREQRRHIYDR 211 Drosophila moja...
NP_001233064 118 ---RRk-LVGAYVEHTNEE--------DEAPPAVSLNARrgsdpmVSIANS-SNVLNRFGHQQDKWKKQVKEQRKNIYDR 184 pea aphid
1_pfamImport  82 yvnKRn-RAAGLLEDETEMdcippaerTRTSSRLSSTGQs-----------kSSVLQKVNQVQTKWKRQLKEQKSSVYER 149
Q6IQA1       129 ---RRl-FGHSQLIQSDDD--------VGDQQPFANAHDv-----LSRSRSrSNMLNKVEHAQQRWRRQVQEQRKSVFDR 191 zebrafish
XP_016790996 118 ---KP--DAYTEQLHNEEE--------NEDARSMAAAAAs-----LGGPRA-NTVLERVEGAQQRWKLQVQEQRKTVFDR 178 chimpanzee
EFX75498     128 ---KK--TTTQYQEHNNEE--------DES------ETHs-----QPLRASgAGVLNRVGQTTDKWKKTVQEQRRHIYDR 183 common water flea
EEC04479     128 ---KR---RAAYQEHVNEE--------VNLDEALPMQQRt-------RRSS-SSVLNKVGQQQDKWKRQVQEQRRNIYDK 185 black-legged tick
XP_015787459 142 ---SRffKRTPYREHFNEEmlvetgpkRSSTESIESTSQp-----ELTYAHsRGVISAIGHEQHKWIRKVSEQRKNIYDR 213 two-spotted spi...
Q21960       257 HTML 260 Caenorhabditis elegans
Q9VNA4       223 HTML 226 fruit fly
XP_002000398 212 HTML 215 Drosophila mojavensis
NP_001233064 185 HTIL 188 pea aphid
1_pfamImport 150 QEML 153
Q6IQA1       192 HVVL 195 zebrafish
XP_016790996 179 HKML 182 chimpanzee
EFX75498     184 HTIL 187 common water flea
EEC04479     186 HTML 189 black-legged tick
XP_015787459 214 HTML 217 two-spotted spider mite
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