3NFV,4E1Y,4OZV


Conserved Protein Domain Family
Alginate_lyase

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pfam05426: Alginate_lyase 
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Alginate lyase
This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyze the depolymerization of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end. This family adopts an all alpha fold.
Statistics
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PSSM-Id: 398861
Aligned: 54 rows
Threshold Bit Score: 99.4482
Threshold Setting Gi: 145574900
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NFV_A         47 SVXDKTXT-ADSGDKHDYXSXGPYWwpDPSKP------------DGLPYIRKDGQRNP-------ELDKLDRNKLGDXSK 106 Bacteroides ov...
EDZ60028       45 DGCITSMYvNQTNNPVLPLAKV----------------------DAPSGYGLDNRFMSaldsfenFKRPCSGGNIEACEN 102 Candidatus Pel...
jgi:Tola_1413  54 DLPSKYVQtEKSKDVIDEENDARYK--ALSAPmsdlqqlsatmtDRL--FKGKGTa---------GDMACLRRHWLAWAE 120 Tolumonas auen...
Q0VSK7         48 KMGSKYDQgQASKDVLDEKAARRYQ--SQVSAiysylaflgqvtEYMRKPDPAIRa---------AAKECFSMAVASWAQ 116 Alcanivorax bo...
WP_012018191   63 QLDSKYDQsDASKSRLVARQSKDTE--RIRQQvkqyigglvkaaQVYQRTGKASDa--------nIALACLSQWLDAWAS 132 Pseudomonas me...
Q1I821         61 QLQSKYDPrDASKSTLRASPDTDSE--RIAGQikpfiaglvqagKRFQQAKKPKQa--------nLALACQAQWLEHWAK 130 Pseudomonas
WP_000819984   34 DLPKKLHLdKKLSQTIQPCAQL----------------------NASKHYTATGVREP----------DKCTKSFKKSAL 81  Helicobacter p...
EDV03878       38 EFMKAKVLaGEEPWKEAWNQLK-----SSEIAslnykptpfkvvDNGPYNKPDN----------------GGKEFVRDGA 96  Bacteroides in...
WP_015845746   20 RLAEESLSvSC---------------------------------HAVPVWHIPGFYFDt------AGHQAAKKLMEADAQ 60  Paenibacillus ...
WP_004291737   29 LLTQKGIEkIKAQNKPAMLFN------TTLTQiknqiypilkqpIEVPLPKDAGGGYTh------EQHKRNYNNM----- 91  Bacteroides eg...
3NFV_A        107 AV-----TTLGLAYYFSGDEKYAQK--AVDF-LNVWFLDAKTKXNPHLTYGQTIPGKnkGXGRGAGXIDIysftEXIDAX 178 Bacteroides ov...
EDZ60028      103 VKrvildWAKSDAAKRTGPSNHEGRhwNDTLtVNLWIASPMMAGYSFV-------------------------------- 150 Candidatus Pel...
jgi:Tola_1413 121 AD-----ALLQPAKTA-----------SGKA-VRKWTLAAISANYLKIKLNLPS-------------------------- 157 Tolumonas auen...
Q0VSK7        117 AG-----ALTQKDASK-----------QGEA-VRKWFLSALAMNMMKA-------------------------------- 147 Alcanivorax bo...
WP_012018191  133 KS-----ALLSDEASK-----------TGVA-SRKWALAAIASTLLKV-------------------------------- 163 Pseudomonas me...
Q1I821        131 AG-----ALLAPDASN-----------TGMA-ARKWALAAMAGSVLLT-------------------------------- 161 Pseudomonas
WP_000819984   82 MS-----YDLALGYLVSKNKQYGLK--AIEI-LNAWAKELQSVDTYQSEDNINF---------------------YMPYM 132 Helicobacter p...
EDV03878       97 AA-----YTMALQWYVEGDKAYAEK--AIEI-FNAWAQTLESVVNHNRQLKVGTAGI--KYLNAAEIIK----------- 155 Bacteroides in...
WP_015845746   61 AA-----YATALAYRLTGRPDYADK--AMEL-LKGWASINRELADKDGPLVSA--------YLGAGFLQ---------AA 115 Paenibacillus ...
WP_004291737   92 -------YNAGVLFQLTEKKEYAEY--VKKM-LIQY-----AEMYPNLPLHPIQKSNyrGKLFWQGLNEC----VWLVYT 152 Bacteroides eg...
3NFV_A        179 TLX--ENSKAFTPKVKKGXKE-----WFTQLVEWXQTSP---VAAEEQRAK------NNHGLAYDVQLTAYALYTGNQDL 242 Bacteroides ov...
EDZ60028      151 -----KQVINVPEDEDKIIKD-----WFQKIVKKNKHLMydmKYKDGTQAIgvpkraHNHALSSAISHMQLGILLSDDKL 220 Candidatus Pel...
jgi:Tola_1413 158 -----EDTPLFPKTEQQALEN-----WLAKLAM--EVMP---DYSNRRPEQi-----NNHDYWAAWGVMATAVVLNRQDM 217 Tolumonas auen...
Q0VSK7        148 -----QALTAWQVS--EEQRD-----WLRLLADRVQIYA---TPRRQRMDLy-----NNHDYWSSWAVMAAGLVLDEPAR 207 Alcanivorax bo...
WP_012018191  164 -----QALSDGRYQLSAVQAR-----WLGQLSA--KVMA---EYEPRRYDRgi--yfNNHDYWAAWAVAATAMLLDDDRS 226 Pseudomonas me...
Q1I821        162 -----QAAADGKVRLSATQQQ-----WFTLLGE--QVIR---EYDPRRTSTtv--yfNNHDYWAAWAVAATGMLVGRDDF 224 Pseudomonas
WP_000819984  133 NMAywFVKKAFPSPEYEDFIK-----RMCQYSQSALN--------------------TNHGAWGILFDVSSALALDDHAL 187 Helicobacter p...
EDV03878      156 -----HTYKGWNAKDRKAFEDmvinvWYPVIKDWTPRYN------------------GNWDAANGQTLMCIGIFLDRRDI 212 Bacteroides in...
WP_015845746  116 EWI--KAYPGWREEDQDQFVY-----WITTVLL---------PEWDRIPLR------NNWWSWSLYAQLLLYRFLDDQAG 173 Paenibacillus ...
WP_004291737  153 SQAydCIYNYLNPKEREFIENn----LFKPMVEFIAIHN---KSTFEKI--------HNHATWAVTGVGMISYVMGDKDM 217 Bacteroides eg...
3NFV_A        243 AXKTI-------QE-FPEKRLFAQIE-PDG---KQPLELAR-------------TTALGYTIFNLGHXLDXCSIAST-LG 296 Bacteroides ov...
EDZ60028      221 FRKAF-------LN--YEAAIRYQRK--DG---SLPIETRRg------------GRAMFYQGRAMNALSVIAIIAEN-QG 273 Candidatus Pel...
jgi:Tola_1413 218 FDWAG-------NV-YQTAM--MQIT-AEG---ILPNELKRr------------SKALSYHNFALQPLVLLAAFGEA-NQ 270 Tolumonas auen...
Q0VSK7        208 LSWAE-------QG-YWLAI--GQITpRNGg-vVLPREAARg------------KRAEEYHAFAITPLILMAEAGTR-NG 263 Alcanivorax bo...
WP_012018191  227 LAWAD-------VA-LRRAF--AQLTpGKGdyqYLPLEVARg------------RLAADYSHYALVPLMLLVEAAEH-NG 283 Pseudomonas me...
Q1I821        225 IRWAD-------GN-LRRGL--AQAV-RRGdyaYLPLEVARs------------KLAANYSQYALVPLVLLSESARV-NG 280 Pseudomonas
WP_000819984  188 LHNSA-------NR--WQEWVFKAID-ENG---VIPSAITRsdtsdyhggptkgIKGIAYTNFALLALTISGELLFE-NG 253 Helicobacter p...
EDV03878      213 FDTAC-------KQ-LLDGDTNGAIK-------NYFYESGQcq---------esGRDQQHVQMGLAFLACAAEIAWN-QD 267 Bacteroides in...
WP_015845746  174 FAEEA-------AH--LKEHIDSSLL-LTG---FIPEETLRg------------TNSIWYHYFALAPLTAAAKQVLDyTG 228 Paenibacillus ...
WP_004291737  218 LEKALygldksgKSgFIRQI--DQLFsPDGy----------------------fEEGPYYQRYSLQPFIMFAQAIEN-NE 272 Bacteroides eg...
3NFV_A        297 Q--DIYNATSQDGRSITAALKFLIPY--IGkPQSEW 328 Bacteroides ovatus ATCC 8483
EDZ60028      274 Y--NIWEY-DYKGKNFHNLVKFFIDF--TEtNEIVF 304 Candidatus Pelagibacter sp. HTCC7211
jgi:Tola_1413 271 Q--HWL---EAKNSALQRLANLVINN--VD-DSHSL 298 Tolumonas auensis DSM 9187
Q0VSK7        264 L--PLY---EGDGQQLHALAAQVVHFwaQDgKGVSF 294 Alcanivorax borkumensis SK2
WP_012018191  284 R--PLT---EQERAKLAGLANFAARA--SL-EPRTL 311 Pseudomonas mendocina
Q1I821        281 L--AWS---DDDQQTLDRLARFAARS--VL-EPDTL 308 Pseudomonas
WP_000819984  254 Y--DLWG--SGAGKRLSVAYNKVATW--IL-NPETF 282 Helicobacter pylori
EDV03878      268 I--DLY---GAFDNRLYKGFEYTARY--MSgEEVPH 296 Bacteroides intestinalis DSM 17393
WP_015845746  229 E--DLFRWTSPSGNTIKKALDTLLYY--ANgRAGEW 260 Paenibacillus sp. JDR-2
WP_004291737  273 PerKIFEY---KNGVILKAVTTLLQM--SEnNGQFF 303 Bacteroides eggerthii
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