5U1D


Conserved Protein Domain Family
Herpes_US12

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pfam05363: Herpes_US12 
Herpesvirus US12 family
US12 a key factor in the evasion of cellular immune response against HSV-infected cells. Specific inhibition of the transporter associated with antigen processing (TAP) by US12 prevents peptide transport into the endoplasmic reticulum and subsequent loading of major histocompatibility complex (MHC) class I molecules. US12 is comprised of three helices and is associated with cellular membranes.
Statistics
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PSSM-Id: 398827
Aligned: 3 rows
Threshold Bit Score: 135.918
Threshold Setting Gi: 44888984
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5U1D_X  1 MSWALEMADTFLDNMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAP----NASLGVVHRRTGG 76 
P03170  1 MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAP----NASLGVAHRRTGG 76  Human alphaherpesvirus...
P14345  1 MSWALKTTDMFLDSSRCTHRTYGDVCAEIHKREREDREAARTAVTDPELPLLCPPDVRSDPASrnptQQTRGCARSNERQ 80  Human herpesvirus 2 st...
5U1D_X 77 TVTDSP 82 
P03170 77 TVTDSP 82  Human alphaherpesvirus 1 strain 17
P14345 81 DRVLAP 86  Human herpesvirus 2 strain HG52
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