Conserved Protein Domain Family
Peptidase_M26_N

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pfam05342: Peptidase_M26_N 
M26 IgA1-specific Metallo-endopeptidase N-terminal region
These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated with pfam00746, they may be attached to the cell wall.
Statistics
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PSSM-Id: 398812
Aligned: 25 rows
Threshold Bit Score: 314.994
Threshold Setting Gi: 147759668
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KXT83652       221 HLEYYTPYTLETVLTYTS-----SQGTAETSLGEVPLELDLKKVELKSISNVDLMKVENGQTKVM-PTLTEKPASLDHYY 294  Streptococcu...
PMC48522       693 GLDYYTLYTLKTKLTYNLg----DFNEYSTETSTKNFHLDYKKLEIKDIDSVELYGKENGRYRRY-LSLSEVPKDTTNYF 767  Streptococcu...
KXT79844       330 GLDYYTDYTLKTQLTYELd----SGSFTELENDSRTFNLEYKKIAFRNIEAAEFYSKENDQYKRL-VSMSALPTDLSNYF 404  Streptococcu...
tigr:SGO_0942 1293 DLDYYTGYTLKTKLTYELd----NGSFTDLETDSRDFELEYKKIAFRDIDSVEFYRKENDQFKRV-VSMGSMPTDLSTYF 1367 Streptococcu...
ESK64742      2673 GLNYEVPYRLVTELTYADk---lGVSKTDPQLSEELVELKLKKFELKQIKEEGLYQVEGQELKRV-SALASVPQDLSGYL 2748 Abiotrophia ...
ESK64739       560 GLDYHVPYRLHTVMDYENq----QGAQSKDQLEDQAIELDLKKIELKQIKGVQLFHRQADGSHQLmASLSQIPSDLSNYY 635  Abiotrophia ...
RLY05371       557 GLDYDTPYEIETSYTYDIg----AGSVTKTLPDRVPFELEIKKIEMRNIVSTKLFEMVDNTPAER-SSLTSQPTDMSKFY 631  Streptococcu...
WP_011836924   551 QVEPPQEYTENIEPATPEa----ENPTEKAQEPKEQKQEPEKNIELRNVSDVELYSLTDGKYKQH-VSLDANPTNQENYF 625  Streptococcu...
WP_067193436   429 SLEVYKGd--------------gSDEFASQGDPIEKQQNLKKTLEVRSISDIELYRVSDGEYKQE-FLLDHFPSDTENYF 493  Streptococcu...
bgi:05SSU1022  617 NLDFYTDYTVKTKIFYTMaeqeqSSEQEAILESMRKFDLVYKKIEIKDIDAVTVYRRKNGSYIGQ-EFLEELPASTDELF 695  Streptococcu...
KXT83652       295 LQFSSEQFKDTVLPVTSIeeiIVDNQPVFKIQAQLPDLLQR--TEKGLQNSFDFYLEKAKP-HDGNIYYDFQDLLEGIRN 371  Streptococcu...
PMC48522       768 AKVKSDRFKEMYLPVQSI---TESADGNYKVTAAINQLVEE--GVEGYKDHYSFSVAKTKA-EQKGVYTSFKSLVAAMQG 841  Streptococcu...
KXT79844       405 VKVKSSDSKEMLLPVHSIsegEKNGKAAYKVTVSLPELVEE--TATGYKSGYDFYISKAGP-SQQNVYTSFTGLLDAMKK 481  Streptococcu...
tigr:SGO_0942 1368 VKVKSSESKEMLLPVHSIaesQKDGRDVYKVTVSLPELVQE--GETGYKSGYDFYISKAAVpSQQNVHTSFAGLLDAMKQ 1445 Streptococcu...
ESK64742      2749 VKVSSDRYKDVVLKVAAIeatTYNGEDYYQVTATAPELVQNngGTTDYHQTHQFLVRKAAP-AVNNVYHSFGELLTAMKA 2827 Abiotrophia ...
ESK64739       636 VKVQSDRFKDVYLPVASIetvSHDGQSYYQVTTQAPELVQNqgGSSDYHQGYQFLVGQERP-ADGNVHYSFKSLLEAIRQ 714  Abiotrophia ...
RLY05371       632 IQIDTTDKRDAYIPVHAIeeaVVDGEAAYKVTVKMDELVQD---RQGYKEDYTFYVRKSKV-SANNTYYNFGDLVTAIKA 707  Streptococcu...
WP_011836924   626 VKVKSSKFKDVFLPISSIvdsTKDGQPVYKITASAEKLKQD--VDNKYVDNFTFYLAKKAE-REVTNFTSFSNLVQAINN 702  Streptococcu...
WP_067193436   494 IKIKSSKWKDRVIPVSSIvesEKNGQAAYKITAYLETANHD--TIGDSGNPVTFYIGKRIK-GEKKVFTSFANLVEAIEK 570  Streptococcu...
bgi:05SSU1022  696 IKVTSDRFKEVYLPVSSIeetTLNGKAVFKLVSSFDELVQD--KDAQYVANREFYIPKMAT--DANTYTSFKALLDAMKA 771  Streptococcu...
KXT83652       372 NPSGTFILGRSISAKLIDKPAASKAYISGEFTGQLIGg-QNGERHA-ILDLAHPLFETI-KGGTVKDIDFKRVNIVypDT 448  Streptococcu...
PMC48522       842 NMSGVFKLGADMTADEVGLLNNGTSYLTGTFTGKLIG--SDGTKSYaIYDLKKPLFETL-RGATIKDLDLKNVDVD--SR 916  Streptococcu...
KXT79844       482 NMAGSYVLGADLDASEVSLAPADYVYLKGNFTGSLTGg-HDGKQYA-IYNLAKPLFENLkSGSSVSNLDLKDVNIV--GT 557  Streptococcu...
tigr:SGO_0942 1446 NMAGNYVLGADLDASEVSLALADYVYLKGNFTGSLTGs-HNGKQYA-IYNLSKPLFENLkSGSSISNLDLKEVNIV--GT 1521 Streptococcu...
ESK64742      2828 NLSGTFILGSNVSAADVVLAKGQEAYLMDTFRGKLLGrgADGQSHA-IFDLKAPLFKET-NQATISNLDLKRVDIR--DR 2903 Abiotrophia ...
ESK64739       715 NPAGDYILGANLSASEVSLAANATAYFVGTFTGTLSGqtADGTQHA-IYNLVAPLFDQL-NQATIKHLDLKQVAIE--SG 790  Abiotrophia ...
RLY05371       708 NPLGHFTLGSDLFAPEAK-----DAYVKE-FSGILTG---GNFA---IYNLTAPLIAKA-SG-KISDLDLKNVKINs-DQ 772  Streptococcu...
WP_011836924   703 DLGGTYYLGASLNANEVELENAASSYIKGRFTGKLFGs-KDGKNYA-IYNLKKPLFDTL-SAATVENLALKDVNIS--GK 777  Streptococcu...
WP_067193436   571 NPNGTYYLGASLNALEVALPEKATSYISTPFTGKLIGe-KDGKSYA-IDHLTKPLFSIL-DGATVENLTLDHVMIS--SK 645  Streptococcu...
bgi:05SSU1022  772 NPSGTFKLGAHLDASEVP-VGDVASYVTN-FSGTLDGl-NDGYAFS-ISNLKAPLFFNL-G-GKVQNLDIKNASLNtsSK 845  Streptococcu...
KXT83652       449 aagDTVAAIAARLKDkGVIENVNVQG 474  Streptococcus sp. DD11
PMC48522       917 ---ENAAALAKTANK-ATISNVSVEG 938  Streptococcus sp. UMB1385
KXT79844       558 ---YDSAALARNADN-ARISDVSAQG 579  Streptococcus sp. DD11
tigr:SGO_0942 1522 ---YDSAALARSAEN-AQITDLSVQG 1543 Streptococcus gordonii str. Challis substr. CH1
ESK64742      2904 ---DNVGSLAVVANQ-TTITDVTASG 2925 Abiotrophia defectiva ATCC 49176
ESK64739       791 ---NSIAALAKRATS-STISDVAVSG 812  Abiotrophia defectiva ATCC 49176
RLY05371       773 ---SFVGALAGELTTgARLENVAVTG 795  Streptococcus sp. 28462
WP_011836924   778 ---TDVGALANEANNaTRINNVHVDG 800  Streptococcus sanguinis
WP_067193436   646 ---ENVGALANEIKHsSHIQNVHVVG 668  Streptococcus sp. DD10
bgi:05SSU1022  846 ---NPLATIAINANG-ATITNVAVEA 867  Streptococcus suis 05ZYH33
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