Conserved Protein Domain Family
RRN3

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pfam05327: RRN3 
RNA polymerase I specific transcription initiation factor RRN3
This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.
Statistics
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PSSM-Id: 398805
Aligned: 101 rows
Threshold Bit Score: 348.084
Threshold Setting Gi: 187036505
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKM79897      41 KDMYLAFVNNALQQKLNgISEPFNELVSQFnprrrttETSSLETSTSLRTWILALTHVVSRLERTHSSLVEAVINTPWTT 120 Agaricus bispor...
CAP24486      52 AAVLYRKICNALETFEQ--------------------WELEAPKLQILEQFLGCADVM----EARTDDLVKRLLALRWDK 107 Caenorhabditis ...
EGT45813      57 MGVLYRKICNALETFEQ--------------------WESELPKIQLLEQFIGHADTM----ETRTNVLVTRLLALRWDK 112 Caenorhabditis ...
XP_002051281  40 EKGIVESVRVALEEN---NFHLIQEFTYFLce--------adLSDDEVVQIMKDARKIVHSLTPEFANLVEALLSLNWKK 108 Drosophila virilis
XP_001966905  37 EKGLAESVRVASEEQ---NFHLVHEFTYFLre--------aeLDDDELEEILKEARKIVHNLTPDFVNVVEALLSLNWRK 105 Drosophila anan...
Q9V9M6        40 EKGLAESVRVALEER---NFHLVKEFTYFLre--------aeLSDDEVVIIIKDAKRIVHNLTPEFVTVVEALLSLNWKK 108 fruit fly
XP_002064674  40 EKGLKESIRVALEEH---DYHLVQEFSYFLce--------adLSDEEVIQIMNDARKICHSLTSNFAGVVEALLSVNWRK 108 Drosophila will...
Q29K22        40 EKGLLESVRAA-QGG---NFHLVKEFSYYLle--------adLDDDEVLQIMKDGRKIVHSLTPDFADVVEALLSFNWRK 107 Drosophila pseu...
XP_001870906  41 DLAVEAVLQDALQNG---QLQRFEVLVLEIka--------eqFDDDKFQQVIVESKRCVHLLNANFGMLVEALLSVNWLA 109 southern house ...
Q16ML1        38 DLSVESVLQDALESN---RLQRFEHLLAAIke--------eqFDDGKFQQVFIESKRSVYMLNANFGMLVEALLSVNWVV 106 yellow fever mo...
EKM79897     121 LDSATVKSYIIFIGMLLSARPGYLSLVLSRVAQGFTYQSgiqtLsQAFPEs----sSSPITRRVIYDRLHYLLQHLLSLI 196 Agaricus bispor...
CAP24486     108 IPQSAIERFRTFLCELAIRHLCFTEHVYTAVVQRLVPQVs-----SDESTgivsfvLTEEKQNEHFEMAHIILSSVIRCF 182 Caenorhabditis ...
EGT45813     113 IPSSIIGKFRTFVCELAIRHLCFTEDVYLSVIQKLVPQYe-----ANQETgivkmvLTEEKQNEVYEMAHYIISSVLRCF 187 Caenorhabditis ...
XP_002051281 109 YSSDAIQAYTEFSVDVMIAHNSYIHIGIGKLILNWIPNDqe-sAeW-LNG------CPSERVRAELETVHSLLNRILTAV 180 Drosophila virilis
XP_001966905 106 RSCKTIEAFTEFSIEILVAHNRYLPMGISKFILHWIPNDqd-aAdW-VNG------CPSNQIYCELKPIHDVINRIITAV 177 Drosophila anan...
Q9V9M6       109 RSSEIIEAYTEFCIELMVTHNRYLPIGVSKLIVHWIPGDmd-eSdW-VHG------CPSEHVRNELKPIHKVLDRILTAV 180 fruit fly
XP_002064674 109 RSSEAIEAYTEFAIDIMVAHSTYIPIGISKFIVHWVPTEne-sSeWQIHG------CPSEIVRNDLETVHKILDRILTAV 181 Drosophila will...
Q29K22       108 RCPEVVEAYTEFSIDIMVAHNTYIPIGLSKCIVHWIPGDlq-aAdW-VNG------CPAEGTRTELKTVHDILNRILTAV 179 Drosophila pseu...
XP_001870906 110 RNESSREVYKGFVIELLVAQGNYTTLAVSKLVQLFLPRDe--dKeGWVRG------VPTVATAERFEPVHDLFVRLKNVI 181 southern house ...
Q16ML1       107 RSETAREIYMDFVIELLVAHSNYTSLAVSKLVQLFVPKDe--eRtGWIYG------VPSEDVLKVLSPIHELIERLKNVI 178 yellow fever mo...
EKM79897     197 PTLPSTLQPLLAQNFPHKRQNQLTQSTYIRNLLRISSYCP-ELSERILATIVDRALQIDV-----E-------------- 256 Agaricus bispor...
CAP24486     183 PLSAKSLLKCLRKAMPHFTQPPVAVSGYMRNLMLMQKYVPlSITKDVWETIFERLAKDDAhnwrcEqneeesksprlfal 262 Caenorhabditis ...
EGT45813     188 PLSAKTVLKCAKRAMPHFTCPAVAVGGFMRNLMLMQKYIPaSIAKDVWETIFERLARDDAhnwrcEqneednksprlfal 267 Caenorhabditis ...
XP_002051281 181 PMSFDVVIDTIASKFPYFKKPAHVTAGYLHNVLWLMEYKP-VFEELLVQLVLQKLLVLDVnaprdE-------------- 245 Drosophila virilis
XP_001966905 178 PMAFDVIVDTISSKFPYFKKPAHVTAGYLFNLLWLLDYKP-VFEEIILQLVLQKLLILDVnaprdE-------------- 242 Drosophila anan...
Q9V9M6       181 PMAFDIIIDAISAKFPYFKKPYHVTAGYLYNVLWLLEYKP-IFEELVFQLVLQKLLLLDVnapkdE-------------- 245 fruit fly
XP_002064674 182 PMSFDVVIDAISAKFPYFKKPSYVTAGYLYNILRLLEYKP-VFEELVMQLVLQKLLILDVnaprdE-------------- 246 Drosophila will...
Q29K22       180 PMAFDVVIDVISAKFPYFKKPAHVTAGYLYNVLWLMEYKP-MFEELVLQLVLQKLLILDVnaprdE-------------- 244 Drosophila pseu...
XP_001870906 182 PMIFDVILVQLRKQFPYFKRATHVVCGYVYNTLRMTDHSA-MFTEELLDIIFYRLVAIDVntprnE-------------- 246 southern house ...
Q16ML1       179 PMIFNVILVQLRKQFPYFKKPMHVICGYLHNVLWMTEHSS-MFSEELLEIIFNRLLTIDVntprnE-------------- 243 yellow fever mo...
EKM79897     257 -----IQVEIE-ELEEEETLEEQplfeldpfdvvvgqegpetsdlsdiddsdedVGDDFSDLSSEAGLEEElapevltnm 330 Agaricus bispor...
CAP24486     263 nddilIEDVIE-TTNDSEDV-TPkll----------------------------------------------------eq 288 Caenorhabditis ...
EGT45813     268 neeilIEDVVE-STNSSEDVTTPevl----------------------------------------------------eq 294 Caenorhabditis ...
XP_002051281 246 -----IEALKE-DTDDEDdkm------------------------------eeqAIFQMDDI------NAPpkpp----q 279 Drosophila virilis
XP_001966905 243 -----IDL----ENHGEEkqm-------------------------------edPLFQIDEIAALTDANKSeel------ 276 Drosophila anan...
Q9V9M6       246 -----IEL----EMNDEEekv------------------------------eadTLFEIDDVCA-ENVPKSeks------ 279 fruit fly
XP_002064674 247 -----IDV----ETDDEEDDDEDrepdk----------------------mdedGIFQMDDIPT----KSPspla----k 287 Drosophila will...
Q29K22       245 -----I-V----ETDEDEdkm------------------------------degDVFTIDDITSDTVVKQPeds------ 278 Drosophila pseu...
XP_001870906 247 -----IE---DaEFPDEADDG---------------------------------QIFAMEETPVIEIDDDE--------- 276 southern house ...
Q16ML1       244 -----IE---DaEFPDDD------------------------------------QIFSMDEDPAVIDEDDNdd------i 273 yellow fever mo...
EKM79897     331 RHIQEMVQKLDSILTLVFDHFKRtsafppnnsagsgrmtaynasrppsppelltlpplpsfsdcavtsplmptstppfld 410 Agaricus bispor...
CAP24486     289 RKGEQTMQYLDAVCTDVIAFIRHseg------------------------------------------------------ 314 Caenorhabditis ...
EGT45813     295 RKGEQTLQYLDSVCTDLITFIQD--------------------------------------------------------- 317 Caenorhabditis ...
XP_002051281 280 sleHPIGHMLDICLLKLFKFLDEkcrp----------------------------------------------------- 306 Drosophila virilis
XP_001966905 277 -vdHPIGQSLDICLHMLYKFFDKkcni----------------------------------------------------- 302 Drosophila anan...
Q9V9M6       280 -vsHPVGKTLDVCLFLLYKFFDGkcrl----------------------------------------------------- 305 fruit fly
XP_002064674 288 tidHPIGQTLDICLAMLYKFLDTkcrl----------------------------------------------------- 314 Drosophila will...
Q29K22       279 -vvHPIGHTLDTCLSMLYKFVDSktri----------------------------------------------------- 304 Drosophila pseu...
XP_001870906 277 TMKLPLAETLDCCLETMFRYIEE--------------------------------------------------------- 299 southern house ...
Q16ML1       274 IMKLPIAETLDCCMQKMFKYIEQr-------------------------------------------------------- 297 yellow fever mo...
EKM79897     411 grtefaptpepstfpppstsssqNHDPMSIMR------------------------IQFNALLSIFDRVILRTFKSRYTQ 466 Agaricus bispor...
CAP24486     315 ---------------------vdAQENEEKGQkieekwlrtfk---ikgdkvlapeNLFDTFLEVLESTMLNATHVQYVS 370 Caenorhabditis ...
EGT45813     318 ----------------------------AEGIseenahqkwlksfkihgdhvmapeKLFDTFLEVLESTMLNATHTQYVS 369 Caenorhabditis ...
XP_002051281 307 -------------------kpdcTDDQRIAKS------------------------RFFKTLVHIFEEVLLPSHNTHHVQ 343 Drosophila virilis
XP_001966905 303 -------------------kpncTDQQRCAAN------------------------RIFNILLFTFDEILLPSHNTHHVQ 339 Drosophila anan...
Q9V9M6       306 -------------------nensSEEQRRTAN------------------------RLFKMLLYLFDEVLLPSHNTHHVQ 342 fruit fly
XP_002064674 315 -------------------apttNEEQRWTAN------------------------RFFKMLLFIFDEVLLPSHNTCHVQ 351 Drosophila will...
Q29K22       305 -------------------lpdcSEGKRWAAN------------------------RFFKTLLYIFDEVLLPSHNTHHVQ 341 Drosophila pseu...
XP_001870906 300 -----------------------RARIEGGSD------------------------RVYGLLLKLFDKHILPTHNTHHVQ 332 southern house ...
Q16ML1       298 ----------------------aTSENTSDAD------------------------RMFKILLALFDKHILPTHNTHHVQ 331 yellow fever mo...
EKM79897     467 FLIFWYTSLDPEFADIFQGMLVERALLGTSatttqlqsefqegeggpsndasgahgSTVARAA--AASYIGSFVSRALFV 544 Agaricus bispor...
CAP24486     371 FIWLYFGSLKEEYEQKVLEHLWQVTIRMPRa-------------------------PADSKKSqgAAAYLAAFLARAKYV 425 Caenorhabditis ...
EGT45813     370 FIWLYFGSLKSEYEMKVLEHLWAITIRMPRa-------------------------PADARKSqgAAAYLAAFLARAKYV 424 Caenorhabditis ...
XP_002051281 344 FVIFYACSIRPAYTEIFLSALWHKVQNPNV--------------------------SSIIRHA--AVSYIASFLARAKFV 395 Drosophila virilis
XP_001966905 340 FVIFFITSLRQTYSEAFLSSLWQKVQNPNV--------------------------SAIIRHG--AIGYLASFLARAKFV 391 Drosophila anan...
Q9V9M6       343 FILFYATSLRSVYSEAFLDSLWTKVQNPNV--------------------------SAVIRHA--AVGYMASFLSRARFL 394 fruit fly
XP_002064674 352 FVIFQVCSLRPAYAEAFLSSLWLKVQNPNV--------------------------SSIIRHA--AVSYMASFMARSKFL 403 Drosophila will...
Q29K22       342 FVIFHVCSIRSAYSEAFLSSLWLKVQNPNV--------------------------SAIIRHA--AVGYTASYLARAKFV 393 Drosophila pseu...
XP_001870906 333 FLMFYCCSFDQSYGERFIEHLLKMVRNPNI--------------------------STPTRQA--AVGYVASLLARAKYV 384 southern house ...
Q16ML1       332 FLVFYICSFKQSYVEYFITYLWKQVCNPNV--------------------------STPMRQA--AVGYIASMLARAKYV 383 yellow fever mo...
EKM79897     545 DGESTRRVVALLCEFLMAHLDDVEES-M-RAQTSTlniggpQHTVFYAVSQAVFLIFCFRWRDLLDLEEedgefnvvgat 622 Agaricus bispor...
CAP24486     426 KKDVAFTWLEEIYTWLKRYVVQFGSGsSqILPGLH------RHGTFYAISQAFFLVFSFRYKEFAKNQEil--------- 490 Caenorhabditis ...
EGT45813     425 KKSTAFTWLEEIYTWLRHYVDQFGSGsSqILPGLQ------RHGTFYSISQAFFLVFAFRYKEFVKDQEml--------- 489 Caenorhabditis ...
XP_002051281 396 PLGTITYYLKELSNWANNYINDSDEFsS-KNCSLK------ANMVFFSVCQAIFYLIAFRARDLTINQ------------ 456 Drosophila virilis
XP_001966905 392 PLCTLTLYLMELSKWAHSYIDDSDEY-S-QNCSLK------SNLVFFSVCQAIFYLIAFRVRDLTATT------------ 451 Drosophila anan...
Q9V9M6       395 PLSTVTFYLKELTRWAHTYIDDSDAY-K-QNCSLK------ANLVFYSVCQAVFYLIAFRAKDLTASS------------ 454 fruit fly
XP_002064674 404 PLSTIKFYLTELSKWSLRYIDDTDEYnS-QNGSLK------ANMVFFSVCQALFYLIAFRAKDLTAGT------------ 464 Drosophila will...
Q29K22       394 PLSTIKLYLNELSNWANSYIGDSDQYsS-QNGSLK------ANMVFFSVCQSIFYLIAFRAKDLT--------------- 451 Drosophila pseu...
XP_001870906 385 PMPLLKKTLQDFSDWVHGYLNRSDSL---HNQSLK------AHLVFYSVCQAIFYVVAFRSKQLTATP------------ 443 southern house ...
Q16ML1       384 PLVLLKSTLQEFSYWVHNYIQRMDSM-H-YNQSLK------AHMVFYSVCQAIFYVVAFRSKHLTSNA------------ 443 yellow fever mo...
EKM79897     623 tdmrqnegtrgeRPRKWMPELaILQRVVNSVLNPLRVCSSNVVMQFARVAQATDFIYCYTI--LESNKRLeyastprdps 700 Agaricus bispor...
CAP24486     491 -----------eAMRRW-----GVGRIVHSPLEPLRYVSKPVARCFSAITRSLQLVYCNHVipIEDVQR----------- 543 Caenorhabditis ...
EGT45813     490 -----------eKIRGW-----GVGRVVHSPLEPLRYVSKPVARCFSAITRSLQLVYCNHVipIEEVQR----------- 542 Caenorhabditis ...
XP_002051281 457 ------------KNLALLNTL-QLSRLAMCHFNPLRYCLPPVATAFAGVTRTHQLAYCHTV--LERNARRklat------ 515 Drosophila virilis
XP_001966905 452 ------------KDLLFLQSL-QLSRLAMCHFNPLRYCLAAIATAFAGVTRTYQLAYCHTV--LERNARRklat------ 510 Drosophila anan...
Q9V9M6       455 ------------KDLLFLQSL-QLSRLAMCHLNPLRYCLAPVATAFAGVTRTYQLAYCHTV--LERNARRklat------ 513 fruit fly
XP_002064674 465 ------------KELLFLQSL-QLSRLAMCHLNPLRYCLPPVATAFAGITRTHQLAYCHTV--LERNARRklat------ 523 Drosophila will...
Q29K22       452 ------------KDLHFLQLL-PLSRIAMSHLNPLRYCLPAVATAFAGVTRTHQLAYCHTV--LERNARRklat------ 510 Drosophila pseu...
XP_001870906 444 ------------KNLAFLQTL-QLTSIANCLLNPLRVCVPGVATAFVAVARAHQIAYCNTI--MERNERRrtfi------ 502 southern house ...
Q16ML1       444 ------------KNLTFLQSL-QLSSIVTCHLNPLRVCLPAVATAFAGVTRAHQLAYCHTI--LERNARRklat------ 502 yellow fever mo...
EKM79897     701 atslainqpaepqsrtplalkifEPGSVIAELNTFFPFDPYRLPRSSSVIKDVYREWSSVA 761 Agaricus bisporus var. burnettii J...
CAP24486     544 ------------------------------PFEDMFPFDGFHLKVSSQFITPLMRKFSPLA 574 Caenorhabditis briggsae
EGT45813     543 ------------------------------PFDDMFPFDGFHLKVSSQFIIPLMRKFSPLA 573 Caenorhabditis brenneri
XP_002051281 516 -------------------iyghDKLMPEETLETFFPFDPYILPLSNKFIEPSYLVYKVHE 557 Drosophila virilis
XP_001966905 511 -------------------vyghEKCMPEETLETFFPFDPYMLKMSNKYIEINYLIYQGNT 552 Drosophila ananassae
Q9V9M6       514 -------------------vyghEKCMPDETLESFFPFDPYVLKLSKKYIETNYMVYQSND 555 fruit fly
XP_002064674 524 -------------------vyghDKAMPEETLETFFPFDPYLLKLSNKYIEPHYLVYKAHD 565 Drosophila willistoni
Q29K22       511 -------------------vyghDKAMPEETLETFFPFDPYMLKLSNKYIEPNYLVYKAHE 552 Drosophila pseudoobscura
XP_001870906 503 -------------------lfnnGALAPDDCLDTFFPFDPYLLKKSGKRIEPIFLQYQSCE 544 southern house mosquito
Q16ML1       503 -------------------vyknESQTPEECLDTFFPFDPYMLKKSGKRIEPIFLQYQACE 544 yellow fever mosquito
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