Conserved Protein Domain Family
Sperm_Ag_HE2

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pfam05324: Sperm_Ag_HE2 
Sperm antigen HE2
This family consists of several variants of the human and chimpanzee sperm antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a family of androgen-dependent, epididymis-specific secretory proteins.The EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages. The translated putative protein variants differ significantly from each other. Some of these putative proteins have similarity to beta-defensins, a family of antimicrobial peptides.
Statistics
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PSSM-Id: 398803
Aligned: 9 rows
Threshold Bit Score: 87.2393
Threshold Setting Gi: 395739367
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002929982   4 SLSLFISLLLVALMPP-GQSRAGNVNHQGTEGlrePRESREESPGQGKNGSPLFHHQEKRqlL-PRTPPYPEPE 75  giant panda
Q3UW43         5 LLPFFASLLFAALLFPaGLSNASSINHLVTEP---PSFPKDEFPARGVNGSQLLHHRVKR--LpPRTPPYHGKS 73  house mouse
NP_001291353   5 LLPSFVSLLLAALLLP-GSSSASSINHLVTEP---PSSPQDEFPAQGGNGSGLLHHRVKR--FpPRTPPYHEPG 72  Norway rat
XP_002818835  49 LLLSVASLLLVALLLP-GSSQARHVNHSATDA---LGELRERAPGQGTNRFQLLRHPVKRdlLpPRTPPYQGDV 118 Sumatran orangutan
XP_003803643   5 FLPPFTSLLLVVLLFS-GLSGTQYVDHSSTEG---PRELGEQSPGHSS------HQQVKRyvLpPRTPPYQEPE 68  small-eared galago
ABI24142       5 LAPS--TLLFVVLLFP-GLSRVTHANRQDPKG---PRK-QEESLGRGTNRSHPLHHQVKRylV-PRKPPFPDTD 70  cattle
Q30KR3         4 pLSPLVSFLLVALMFP-GPSRARNINHQGTEG---PREPWEESPGQGKNESHLLHHREKRrlL-PRTPPYLEPE 72  dog
2_pfamImport   1 FFSAFVSLLLVALMFP-GRSRAGSVHHPDAERlraLRESGEASPGQEKIGSPLPHHQEKRylL-PRTPPFPEPE 72 
XP_030664984   5 LLPFVASLLLVALLFP-GSSQARHVNHSATEA---LRELGEGAPEQGTNGSQLLHHPVKQdlLpPRTPPYQEPA 74  northern white-cheeke...
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