Conserved Protein Domain Family
SDA1

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pfam05285: SDA1 
SDA1
This family consists of several SDA1 protein homologs. SDA1 is a Saccharomyces cerevisiae protein which is involved in the control of the actin cytoskeleton. The protein is essential for cell viability and is localized in the nucleus.
Statistics
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PSSM-Id: 398789
Aligned: 123 rows
Threshold Bit Score: 123.898
Threshold Setting Gi: 557733150
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4QE53       418 MNADLLKDLAEYKNRRgDKGVMMAARALIQLYRDVYPELLPAKLRGSKAGVADTATRPVYGSKHVYtDIPGLElLYHDIE 497 Leishmania major
Q7KKH3       409 MGEDLLQDLAMYKTYK-EKSVMMAARSLITLYREQLPALLHKKDRGRQTEAQAERKVRAYGEREVHdTVLGAEaLLKDSK 487 fruit fly
XP_002074816 410 MGQDLLQDLAMYKTYK-EKSVMMAARSLISLYREQLPALLHKKDRGRQTEAQAERKVRAYGEREVHdTVLGAEaLLKNSK 488 Drosophila will...
Q16XM0       325 MNEDLLRDLTMYKNYK-EKSVMMAAKSLILLYREQMPTLLAKKDRGRPTEASVEIKPKKYGEVQAMdHIPGTEaLLNAAP 403 yellow fever mo...
EDS30309     409 MNEDLLRDLTLYKNYK-EKSVMMAAKALILLYREQIPTLLAKKDRGRPTEASVEIKPKKYGEVQAMdHIPGTEaLLNAAP 487 southern house ...
XP_004925875 408 iGEDLLRDLVQYKSYK-EKSVMMAARSLIQLYRQSMPELLHKKDRGRPTEASIELKTKKYGELETKdYIPGSEvLLEKEK 486 domestic silkworm
XP_001946841 411 MTEDLLRDLAQYKNYR-ERSVMMAAKSLIHVYRSSMPHLLHKKDRGRPTEASLEIVARKYGEVDAKeFVSGAEiLLDTEN 489 pea aphid
XP_011138326 408 MNRDLLEDLTQYKQYK-ERSVMMSARSLIGTFRRIMPDLLHRKDRGRPTEVNIAIEASKYGEVRASeFVPGADvLFGKHI 486 Jerdon's jumpin...
XP_001605750 407 MNEDLLQDLAQYKNYR-ERSVMMAARSLIGLFRQTMPDLLHKKDRGRPTEASVALEPLKYGEVAATeYVAGAEvLLESKK 485 jewel wasp
XP_314731    327 MNEDLLRDLTMYKNYK-EKSVMMASKALIMLYREQMPTLLAKKDRGRPTEASVEIKAKRYGEINAAeYIPGTEaLLREDA 405 Anopheles gambi...
Q4QE53       498 NNAGDDESGSESss-sEVDSSSGEwvtdsdseadaddvdgeFVDVADSSAeeedesedgcpqlvpvhehahsatdrtdad 576 Leishmania major
Q7KKH3       488 TIDIESE-DDTDsn-dGE-----------------------WVNVAHSDGeg---------------------------- 514 fruit fly
XP_002074816 489 TIDIDSD-EDTDsn-dGE-----------------------WVKVDHSDNeg---------------------------- 515 Drosophila will...
Q16XM0       404 ALEVDEE-EDEDgs-dSDGN---------------------WVDVDSDDEviee-------------------------- 434 yellow fever mo...
EDS30309     488 DLDVS---DEEDds-dSEGG---------------------WVDVDSDEEplee-------------------------- 516 southern house ...
XP_004925875 487 EKNNDKKKSEKNkk-qKNDSDSEE-----------------WVDVASSASe----------------------------- 519 domestic silkworm
XP_001946841 490 NDSA----DDSNes-cDDE----------------------WVNVSHSENe----------------------------- 513 pea aphid
XP_011138326 487 EETDHSDSEDNE-----------------------------WINVSHNSDeevnd------------------------- 512 Jerdon's jumpin...
XP_001605750 486 DTLE----IDSEnsddDDE----------------------WIDVQHSSDeggevgeg---------------------- 517 jewel wasp
XP_314731    406 PELEGDAGPGGDes-dSD-----------------------WIDVDSSEDefeaalreekg------------------- 442 Anopheles gambi...
Q4QE53       577 gegphkrarleeaapvsvasQNSAAlSESSAdnedegmdsdgdedgeevvsndeeaedesefgweevsddeesec----- 651 Leishmania major
Q7KKH3       515 ------------------ggADDDEeDEDEDeddddededeensndeene------------------------------ 546 fruit fly
XP_002074816 516 -------------------vANQDEdDDDESeddddddgdeedgedgeeendd--------------------------- 549 Drosophila will...
Q16XM0       435 ----------------kkkgITMIKkSKPDEeasdeeeededddgewetdseggsediedeeedde-------------- 484 yellow fever mo...
EDS30309     517 ----------------kkkgITMVKnGDQEDsdgdeeqseeegsddgewetdseadgeev-------------------- 560 southern house ...
XP_004925875 520 --------------------IEISDsEESDIdengeaeqcdvddtdnm-------------------------------- 547 domestic silkworm
XP_001946841 514 --------------------------ISDDEnidgedededvndsdddnedientsd----------------------- 544 pea aphid
XP_011138326 513 ----------------eksiVDADQsIESSAsddddddnddyydddddddddkeqgknnkngdddftfynek-------- 568 Jerdon's jumpin...
XP_001605750 518 ------------ewetddeeNEEDGsDDDEEgdededegsevddddsgseeddedegsdeeneedseakkktmngnkkdk 585 jewel wasp
XP_314731    443 ---------kkgitmiksskNKKKEdEEDEEdedeeeeedeeddedeeededdegdwedcsde----------------- 496 Anopheles gambi...
Q4QE53       652 -------------------deestaeeneeaplslsaalanansgadwfedltdgmssknasSSPRAGSVSSSKASStts 712 Leishmania major
Q7KKH3       547 --------------------------------------------dednsdegvesgeesakaKKEKKDMRILNQKEAaqe 582 fruit fly
XP_002074816 550 -----------------------------------------eesdsdgaaesdpesstskekKNKSLEVKMLNQKEAaqe 588 Drosophila will...
Q16XM0       485 ---------------------------depeeeveekpepsrknankkqakkrssnstsipaEQVASAGTTLTSKEAvqe 537 yellow fever mo...
EDS30309     561 ----------------------------------eddeeeeeqeppvkrqkivkkattkkasEESTAAATTLTSKEAlqe 606 southern house ...
XP_004925875 548 ----------------------------------------------fdrpedtvqkneerkiLKAKRKLDNEEKVKCare 581 domestic silkworm
XP_001946841 545 -------------------------------------tegindtdqsistqnsttniitkkkKVISKKEQLAEKKEKaaq 587 pea aphid
XP_011138326 569 ---------------------dsikndcgnnnekretdktlrkknvltkqqkkarklkktkqNTEQNTELIAERKIKasl 627 Jerdon's jumpin...
XP_001605750 586 ikekkvkkekgdakkkegedklntsdgkpsvkvnalkkknkrsklerkkrklqeklklqeklKAQKKTEYTAEKKAKasq 665 jewel wasp
XP_314731    497 -------------------------------eeeeqkqieeqkqkkskkrgnkeaetvseqpAEEKPGEQTLNTAEAmqe 545 Anopheles gambi...
Q4QE53       713 ISSSRLLTDSDFQKINQLRTQHGSHQSLRGKRkerDV------RSKkrhdLIHgisndldAHDIEHFTeKKRETDKQAKI 786 Leishmania major
Q7KKH3       583 LALTRIFTDEDFKRINAANLKKTVTSARK------RPle--qdRAE----FVK-------LNSIEMIY-KKRKHDKESRL 642 fruit fly
XP_002074816 589 LALTRIFTDEDFKRINAANLKKTVTNARK------RPle--qdRSE----FVK-------LNNIEMIY-KKRKHDKDSRL 648 Drosophila will...
Q16XM0       538 LALTKIFTDADFQRIEQEQIKKKMTHNSRK-----RQle--keKSE----FVK-------LDDIELIY-KKRKTDKEARI 598 yellow fever mo...
EDS30309     607 LALTKIFTDADFARIEQEQVKKKMTHNNRK-----RQle--keRSE----FVK-------LDDIEMIY-KKRKTDKEARI 667 southern house ...
XP_004925875 582 IAMETIFTDEDFKRIEAAQIKKNISGVKRKSNtniEEee--aeSGE----LVQ-------LGAIENIY-KKKKHDKNARL 647 domestic silkworm
XP_001946841 588 VSSMRILSDEDFKRIEIAQLSKQMTSAKNRKRpaePEes---sRGE----LVR-------LKDIENIY-KKRKHDKQTRI 652 pea aphid
XP_011138326 628 ISTERLFTDEDFRKIDIALVKQEVTYANRGVKrvhDQietvkqNGE----LVK-------LCDIENIY-KKRKHDKAARL 695 Jerdon's jumpin...
XP_001605750 666 VSAERLLTDEDFKRIDMALVKQQVTHAKRGVKrpaDEdk---gKGE----LVR-------LTDIENIY-KKRKHDKQARL 730 jewel wasp
XP_314731    546 LALTKIFTDADFARIEQERVKKQVTHHSRK-----RQle--teRSE----FVK-------LDAIEMIY-KRRKADKQARV 606 Anopheles gambi...
Q4QE53       787 EQAQELRKASSKFELRRKKKSKLNSTHGEHSKRGKLFQMTKRsqrvaaKLKSSVAdRATRAKEMQKKDIKFRIKRG 862 Leishmania major
Q7KKH3       643 ETVQAGRQDRERFGWKDGRVNEHCSKTNREKRKTKNFGMLRH------KARSKVK-KSFKDKQQALRKHLLHQKKM 711 fruit fly
XP_002074816 649 ETVQAGRQDRERFGWKDGRVNEHCSKTNKEKRKTKNFGMLRH------KARSKVK-KSFRDKQMALRKHLLHQKKM 717 Drosophila willistoni
Q16XM0       599 ESMKKGREGREKFGYKDNRHDPFCSKTNTEKRKNKNFNMIRH------KARGKVK-KSFREKQLALRKHLTHMKKM 667 yellow fever mosquito
EDS30309     668 ESMKRGREGREKFGYKDNRHDPFCSKTNREKRKTKNYNMMRH------KARGKVK-KSFRDKQLALRHHLMKQKKM 736 southern house mosq...
XP_004925875 648 ESVMKGREDRQKYGYKDRRKNANCSKTNREKRKTKNYQMVKH------KAKGKIK-RSFKEKQIAFRNYLIKQKKM 716 domestic silkworm
XP_001946841 653 DSIKKGQEGREKFGYKDGRLNPFSSKTNREKKKTKNFMMIKH------KAKGKAK-KSFKDKQIALRNHLTKLKKM 721 pea aphid
XP_011138326 696 ESVKKGQEEREKFGYKDGRQNPLCSKTNREKRKGKIFQMLKH------KLKGKAK-RSFKNKQIALRNHLLKQRKM 764 Jerdon's jumping ant
XP_001605750 731 ETVQKGQEGREKFGYKDGRQNPLCSKTNRERNKKKNFQMIKH------KVKGKIK-RSFKDKQVALRNHLVKLKRM 799 jewel wasp
XP_314731    607 ESMQRGREDREKFGYKDNRMNPLCSKTNREKQKNKNFTMIRH------KVRGKVK-KSFRDKQMSLRKHLLHVKKM 675 Anopheles gambiae s...
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