4F88,2VPM


Conserved Protein Domain Family
CHAP

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pfam05257: CHAP 
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CHAP domain
This domain corresponds to an amidase function. Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Escherichia coli gss, where it functions as a glutathionylspermidine amidase EC:3.5.1.78. This domain is found to be the catalytic domain of PlyCA. CHAP is the amidase domain of bifunctional Escherichia coli glutathionylspermidine synthetase/amidase, and it catalyzes the hydrolysis of Gsp (glutathionylspermidine) into glutathione and spermidine.
Statistics
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PSSM-Id: 398775
Aligned: 491 rows
Threshold Bit Score: 29.3072
Threshold Setting Gi: 123074211
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4F88_2                     323 QVGKYIgDgQCY-----A-WVg-WWSarVCgysisystgdpmlpligdgmnahsihlGWDWsian-----------tgiV 384 S...
Q1CQN9                     177 VDKDGAyGtQCCdl--pC-FIvkNWFg------------------------------IDLWgnai-----------dllN 212 S...
AGE61206                    20 DKDGAw-GyQCAdl--sC-FIvkKWRg------------------------------VDLWgnaidl------lnsakaQ 59  S...
EGF88446                    20 DFDGVy-GaQCVdevnrYlYK--FWKikLP---------------------------GNAIdlle----------sakrQ 59  G...
EGV15405                    22 DYDGMy-GyQCA-----D-LT--CMGvyKFf-------------------------gARLWgnai-----------dllR 56  S...
REF_DMICGU:Ssal_phage00007  22 DADGAw-GtQCV-----D-LP--NSIsiNFf-------------------------gRALWgnaidll-----nsaaeaG 62  S...
EGV02614                    21 VDNDGAyGtQCA-----D-LP--CYImrQFfdvs-------------------lygnAYDLlas------------aesQ 61  S...
WP_014678069                21 VNYDGAfGsQCV-----D-LP--FWIlgKFfgrp-------------------isgnAIDLlns------------akaA 61  S...
CAO77370                    48 VDTDQVyGmQCV-----D-----IDT--DL---------------------------TNNYvgipisgnaidlldsarrA 88  S...
AAT72397                    22 TVPTNPyGgQCV-----A-LI--DKIvqEEtgk----------------------nmSYTNaidc-----------ldkA 60  S...
4F88_2                     385 N-----YP----VGTVGrkedlR-VGAiwcATAF----SGAPFYTgqYGHTGII-ESWs-D--Tt-VTVLEQN 438 Streptoc...
Q1CQN9                     213 SasaqgLEviynAPGVN-----PkASD---LFVM----EVAGSP---YGHTGAV--IEdsD--GytIKTVEQN 266 Streptoc...
AGE61206                    60 G-----IKvvpyAPGIK-----PkAGW---IFVMhyvaGDGId----YGHTGVI--VEdsD--GnsMRTVEQN 111 Streptoc...
EGF88446                    60 G-----MTviydAPGVN-----PkAGD---VFVM----SVPTHP---YGHTGVV--LEdsD--GytIKTVEQN 108 Gemella ...
EGV15405                    57 Sae--aAGlqvvYGAQY-----PkAGW---FFVK----NFVAGDGvnYGHTGLVyEDS--D--GstIKTIEQN 111 Streptoc...
REF_DMICGU:Ssal_phage00007  63 Yev--eYNqvgnLDSRP-----R-RGA---VFVMdttyIAGHP----YGHTGLV--IEdsD--GytMRTIEQN 116 Streptoc...
EGV02614                    62 Gvd-vrYD----VAYPE-------AGW---IFVKsfvaGDGVN----YGHTGLT-VEDs-D--GltVKTIEQN 111 Streptoc...
WP_014678069                62 G-----YQviydAPGVN-----PrVGD---IFVMhsiaYDGKD----YGHTGLV-IEDs-D--GhsIKTIEQN 113 Streptoc...
CAO77370                    89 G-----YEi--vPANKP-----PrAGD---LFVM----DTNALYGhpFGHTGYV-YKV--NpdGs-FETVEQN 138 Streptoc...
AAT72397                    61 Kan--gFQvtydAVGVN-----PqAGD---FYVI----RVPSHS---FGHIGVC--LA--DsdGtgLEGVEQN 112 Streptoc...
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