6S7O


Conserved Protein Domain Family
Ost5

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pfam05251: Ost5 
Oligosaccharyltransferase subunit 5
Eukaryotic N-glycosylation is catalyzed in the ER lumen, where the enzyme oligosaccharyltransferase (OTase) transfers donor glycans from a dolichol pyrophosphate (DolP) carrier (Lipid-linked oligosaccharide; LLO) to polypeptides. The yeast OTase is a hetero-oligomeric complex composed of essential (Ost1, Ost2, Wbp1, Stt3, and Swp1) and nonessential (Ost3, Ost4, Ost5, and Ost6) subunits. This domain family is found in Ost5. The precise function of this subunit is not known, however Ost5 appears to form a sub-complex with Ost1, and this sub-complex associates with the catalytic Stt3 subunit of OTase. Down regulation of Ost5 resulted in a limited effect on glycosylation and no effect on the stability of Ost1 or Stt3 subunits.
Statistics
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PSSM-Id: 398770
Aligned: 166 rows
Threshold Bit Score: 29.8481
Threshold Setting Gi: 695431204
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6S7O_C        7 SRYTSPVNPAVFPHLTVVLLAIGMFFTAWFfvy--evtSTKYTRD--IYKELLISLVASLFMGFGVLFLLLWVGIYV 79 
GAO46811     14 TPYVPSISIDQHSTVAATCLVLALSLLGFSttsi-----------sspIVRTASALISPLFFGFGALYLLLAAGVYV 79  Saitoella complicat...
XP_003672121 14 VPFQPIFQLATQPKFAIIASIISLLLITLSlsvs----sseKHFMtkLIFCATINIMASGFVGIAAVFAANSFGVYV 86  Naumovozyma dairene...
EDO15368     14 RAFEPVFALESQPTMAIVASLISLVLVSLSilvm---kskNHSIVvkFIIFSIISAIASLFCGITTVFTTNSFGVYV 87  Vanderwaltozyma pol...
CCE92195     14 EPFEAPFALDSQPKYAVLSLIISLMVISLAlata----wskRSFPvkLIIYTVLSFIGSLFCGSAAVFLANSWGVYV 86  Torulaspora delbrue...
CAR31063     14 ETFEPVFQLSSQSRYALFSLVIAVLLISMAlvsa----yskKGFLirLAIFAALSAAGSMFSGIGVVFLANSLGVYV 86  Zygosaccharomyces r...
EGV61308     19 SEIHPSIVYRNLGLVTVLLLVLTLLSLATAlmv--------nlKNksHVSYLVSASIASLSIGFGSILLSNYVGVYI 87  Yamadazyma tenuis A...
XP_004200969 19 VPIAPSPWSQHSTWVAALLTVIAFMSLSLAllv--------ysKSksTGKFLFNAIIASLSIGVGSIYVSNNFGVYV 87  Pichia farinosa CBS...
XP_007377101 30 VQLHAV--TTNTTIFTAVLILIAFGSLSLIflg--------dvKNkgLVNYVLNSLVASLAVGLSSIYISNFVGVYI 96  Spathaspora passali...
XP_003685781 14 PPFEASFTLDSQPTYAIIGALISLLLLSMSttvtssktFANTNFIikFISFAIVSAVTALFCGITAVFTSNSFGVYI 90  Tetrapisispora phaf...
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