Conserved Protein Domain Family
CHASE2

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pfam05226: CHASE2 
CHASE2 domain
CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE2 domains are found in histidine kinases, adenylate cyclases, serine/threonine kinases and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognized by CHASE2 domains are not known at this time.
Statistics
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PSSM-Id: 398754
Aligned: 425 rows
Threshold Bit Score: 49.628
Threshold Setting Gi: 123502396
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Spiaf_1512  24 VCLLvLllqfTPLVSR-------LETMVLDAHFHwrYRf-----dAagsvregvtfraqnpnvhpdILIIGVDNNALNrf 91  Spirochaeta a...
CDK98756        21 LAVFaL-------LLVpqa-rtrLDHLAFDTLQN--LWprp-yvqVp-------------------VRIVDIDEESLAkl 70  Magnetospiril...
Q12FL5          29 SGLAlW-------FTDpip-vqsLRLAQFDQFQR--WHprp-ytpAa-------------------VRVVDIDEASLKay 78  Polaromonas s...
WP_013790371    20 GLCVvF-------LLDpvp-vqkARNAVFDQYQR--WQprp-yqdTp-------------------VRVVDLDEQSLAri 69  Pseudomonas f...
WP_013820703    23 gCGSlY-------LWEplp-lqiLRNATFDQFQR--LKprv-yhdAp-------------------VRIVDIDEESLKrl 72  Methylomonas ...
EIC30436        21 cAAAlQ-------AADpvp-aqiVRNATFDQFQR--LKprd-yqiSp-------------------VKIIDIDDASLTrl 70  Methylomicrob...
WP_011764363    16 AAAAaH-------LLQpgm-aktLRYAVFDQYQR--WFprp-psaVp------------------dVVVVDIDDESLSrl 66  Azoarcus sp. ...
WP_011712786    19 LLMVlI----IIQIVDppl-rqrLRLMSFDQLQQ--LSprvypehLp-------------------LRVIAIDDASLQsi 72  Magnetococcus...
WP_012111430    18 VLVLsV----FVAINDphgagtfLQNRAFDLYQR--ILpreagagGp------------------hAVYVDIDTETAKrf 73  Parvibaculum ...
jgi:Swit_1235    8 GLLVlA----VAALLSafa-geaMRRPLFDLWQR--LAprd-lsgTp-------------------VHVVLVDSDSIAav 60  Sphingomonas ...
jgi:Spiaf_1512  92 GRWPFDRRIHGNFVNNLariQNQdaRERALFLDFffsepa----------------------------snptdDAMLVHS 143 Spirochaeta a...
CDK98756        71 GQWPWPRHSLAALVESL---RAA--GAAAIALDIilaepdrtaparvsadw------plspamrqtiqtlpdpDAVLAAA 139 Magnetospiril...
Q12FL5          79 GQWPWPRTRLAELVQRL---DEA--GTAAIAFDVlltepdrtspaamaql-------wnnprvgaalqrlpdhDEVLGKM 146 Polaromonas s...
WP_013790371    70 GQWPWPRTQVAEMVERL---EKA--GAAAVVFDVlfaepdrtspeqllrgn------llppalatqmaalpahDEQFAEV 138 Pseudomonas f...
WP_013820703    73 GQWPWPRTRIAELLTTL---QAA--EPAAIAIDIifaeqdrtspqamlnfw------rlsdekkqllgtlpdhDAELAEA 141 Methylomonas ...
EIC30436        71 GQWPWPRTRIAELIGLL---KAA--KPQAIAFDIlfaeadrtspqamlkfw------pvseslrqtlahlpdhDRVLADA 139 Methylomicrob...
WP_011764363    67 GQWPWPRTRFAVLQRRL---AEA--GAVAVGYDIlfaerdrsspavlardl------alpgalareldalpdhDEVFAAS 135 Azoarcus sp. ...
WP_011712786    73 GQWPWPRTRIAEIVAQL---NAM--GAQAIAFDMlfaepdrtspkqmmqnw------pgqsalqtalaklpdhDEIFAQQ 141 Magnetococcus...
WP_012111430    74 GAWPWPRKRLDMLVEKV---RDA--GASAIVIDMtladadptatsellrlwspfpagekfngfsrtlsglpnhERELAAL 148 Parvibaculum ...
jgi:Swit_1235   61 GPWPWPRYHMARLTEEI---AAR--GPKAIGFDMlfpepdrvrpdifaaly-----pelspaaaaevqalppmDRLYGQV 130 Sphingomonas ...
jgi:Spiaf_1512 144 MRQsgrvflenvltfdpprtqdyqtffrRqhalqntaGtItdvsgdwqnmlsfqgveaplipygnaVr------------ 211 Spirochaeta a...
CDK98756       140 IAG-------------------------G--------S-V--------------------------Vtgfaashqpagaq 159 Magnetospiril...
Q12FL5         147 LDG-------------------------R--------N-V--------------------------Vlgsslsrsgeana 166 Polaromonas s...
WP_013790371   139 LKR-------------------------S--------N-V--------------------------Vlgfaaeqslhdgg 158 Pseudomonas f...
WP_013820703   142 IRH-------------------------S--------T-T--------------------------Slgfalsaaqspqa 161 Methylomonas ...
EIC30436       140 LKG-------------------------S--------G-V--------------------------Vlgftaagpnpada 159 Methylomicrob...
WP_011764363   136 LGA-------------------------P--------P-A--------------------------Vlgfavdrengggt 155 Azoarcus sp. ...
WP_011712786   142 IAQssvvt----------------gfvtA--------S-P--------------------------Atlakdvsgqpqpk 170 Magnetococcus...
WP_012111430   149 LSSs------------------------K--------S-V--------------------------Vsfvpgktsfdgqh 169 Parvibaculum ...
jgi:Swit_1235  131 VGK-------------------------A--------P-V--------------------------Vlgragvasggtdp 150 Sphingomonas ...
jgi:Spiaf_1512 212 ----------------------------------------------GYGHANFiaDNDEVFRRqplvakiseVVAlYDih 245 Spirochaeta a...
CDK98756       160 stakarfifsgp----------nplaalpdlgqgvrslpaleqaaaGTGAIAFtaDGDGIIRRv--------PLI-VRlg 220 Magnetospiril...
Q12FL5         167 saapaanvpsalpyrivssgasnpaqwlhgfdiglwplpvlqsgaaGLGALNFaaDADGVVRRv--------PLL-LRlg 237 Polaromonas s...
WP_013790371   159 ppmsrfglvqqg---------pspltfvpgfqgaarplpqleqaarGLGAMTFrpDADGVVRRv--------PLF-VSlg 220 Pseudomonas f...
WP_013820703   162 ppvvkahyvqig---------asplpyllpfqgalsplpvlesaavGNGALTFisDADGVIRKv--------PLL-LRyq 223 Methylomonas ...
EIC30436       160 hplpirarfielg-------nplaterlsyidgilaplpplaaaaaGNGALNFtpDADGVIRKi--------PLL-LNnr 223 Methylomicrob...
WP_011764363   156 tgvkwpfrivtrg--------vdalpvtaeahaavmplpglaaaaaGLGSISFaaDGDGVVRRv--------PMM-MRla 218 Azoarcus sp. ...
WP_011712786   171 gglfvfggdi--------------rtmlpdyqaatvnlplleqaaeGNAVLELpaDTDGILRHl--------PLF-YRig 227 Magnetococcus...
WP_012111430   170 tparpasitpsg---------gdprhymrdyetwrpslplfeaaatGNGASLPerDHGETIRGl--------PML-TAld 231 Parvibaculum ...
jgi:Swit_1235  151 aqlfvdaaikg-----------alppdlpdepravanipelegaalGHGLLNGqpDSDGRVRRv--------PLL-MKlg 210 Sphingomonas ...
jgi:Spiaf_1512 246 ellqdqsvdllqyqrlawldrfgeqhtielplteqggqqlldsleergapytredgsssyrirlfqdhfvpSITLSLALe 325 Spirochaeta a...
CDK98756       221 dq------------------------------------------------------------------lhpSLALEALRv 234 Magnetospiril...
Q12FL5         238 qq------------------------------------------------------------------ivpTLSAEALRv 251 Polaromonas s...
WP_013790371   221 ge------------------------------------------------------------------lrpSLVAEALRv 234 Pseudomonas f...
WP_013820703   224 nt------------------------------------------------------------------lvpSLTAESLRl 237 Methylomonas ...
EIC30436       224 gq------------------------------------------------------------------ivpTLVAETLRi 237 Methylomicrob...
WP_011764363   219 dg------------------------------------------------------------------wvpALDAELLRl 232 Azoarcus sp. ...
WP_011712786   228 sa------------------------------------------------------------------tfpTLGLESIRl 241 Magnetococcus...
WP_012111430   232 gt------------------------------------------------------------------lypSNVLEALRv 245 Parvibaculum ...
jgi:Swit_1235  211 gr------------------------------------------------------------------ampSLSLELARl 224 Sphingomonas ...
jgi:Spiaf_1512 326 ymnv--------------------gihdIevvlgshiLIrepqmyVpaedswqpfQVMdrpprynrdgeltrearyrqvd 385 Spirochaeta a...
CDK98756       235 atgkrnilvk--------aaaetgaltqLal-----gPLq-----Ipv-----daQGS---------------------- 269 Magnetospiril...
Q12FL5         252 aqgernhll----------rsteagvqdVri-----gGVt-----Vpt-----naQAE---------------------- 284 Polaromonas s...
WP_013790371   235 aqrtgryrl----------issdsgvqrVdi-----gRLq-----Ipt-----aaSGE---------------------- 267 Pseudomonas f...
WP_013820703   238 aqkadnytlrsq---adglglaeigigdIrvp--------------------ttpGGE---------------------- 272 Methylomonas ...
EIC30436       238 aqrtqnitlv-------aesensggigaIri-----gKLv-----Lpt-----taRGE---------------------- 273 Methylomicrob...
WP_011764363   233 aggghnlvl----------egeggqlaaLrv-----gARr-----Lpv-----tsAGE---------------------- 265 Azoarcus sp. ...
WP_011712786   242 flglnqlavtasaqdd-------------algpaglrrlklasieRpi-----taAGE---------------------- 281 Magnetococcus...
WP_012111430   246 arggagyravvrapesgfsfeiepglerVeit---gtGLh-----Alt-----qkNGE---------------------- 290 Parvibaculum ...
jgi:Swit_1235  225 ardqea---------------vtaeargVvl-----aGRr-----Ipv-----daEGR---------------------- 252 Sphingomonas ...
jgi:Spiaf_1512 386 eLRIpidahgqmliNYvgprssssaqgiqtfpvrsyagyasritGpDPytwpatMAL-------------ENKIVMAGAF 452 Spirochaeta a...
CDK98756       270 -VHL----------HYtkp-----------------------qaE-RF------VPAwkvldgsadpralDGHVVFVGAS 308 Magnetospiril...
Q12FL5         285 -IWL----------HYted-----------------------qpD-RF------VSAaqvlgrktdrkllDGHIVLIGSS 323 Polaromonas s...
WP_013790371   268 -LWV----------YFtrp-----------------------qaS-RS------IPAwqvldg--sappvAGSIVLVGTS 304 Pseudomonas f...
WP_013820703   273 -IWI----------NYspp-----------------------dsR-RY------LPAwqvlagridenrlRNKILLIGTS 311 Methylomonas ...
EIC30436       274 -IWL----------HYtpp-----------------------epM-RY------LPAwkvltgrappadlQNAILLVGTS 312 Methylomicrob...
WP_011764363   266 -AWL----------HYaaa-----------------------peQ-PF------LPAwrvlsadaplaslQGRIVLVGSS 304 Azoarcus sp. ...
WP_011712786   282 -VFL----------HYrpl------------------------npsRY------ISAaellkgkvepaliANHLVFIAAT 320 Magnetococcus...
WP_012111430   291 -LRL----------YFgge-----------------------atR-RS------IPAgsilsgganlgalAGRIAIIGVS 329 Parvibaculum ...
jgi:Swit_1235  253 -MRL----------RFgrf-----------------------paA-EI------SSAadvlrrkfpadafAGKIVLLGLA 291 Sphingomonas ...
jgi:Spiaf_1512 453 AtGMADdeQATPFg-MMYGVEMHANALNTIL-------MdnfLHPVSFWHNLMVLlaltmLTAWV 509 Spirochaeta africana DSM 8902
CDK98756       309 AkGLLDl-RLTPHgdIVPGVVMHAEAAEAAQlgalpqrPdwmE---------GAE-----TLLAV 358 Magnetospirillum gryphiswald...
Q12FL5         324 AaGLMDl-RFNPMgrMMPGVQAHALALEQVLsnqylqrPawaG---------GVE-----VLTLV 373 Polaromonas sp. JS666
WP_013790371   305 AqGLQDl-RFSPLggIIPGVEVHAQALEQVLtdtlllrPgwaT---------AVE-----GLALL 354 Pseudomonas fulva
WP_013820703   312 AqGLMDl-RFSPLggVIPGIEVHAQALEQILagvhlirPgwaN---------ALE-----MLVIL 361 Methylomonas methanica
EIC30436       313 AqGLMDl-RFSPLghILPGIDIHAQALEQMLsghyllrPswsG---------ALE-----LVIAI 362 Methylomicrobium album BG8
WP_011764363   305 AkGLLDl-RFSPLgeVVPGIEIHAQALRQALagrfpvrPqwaE---------AFE------LLML 353 Azoarcus sp. BH72
WP_011712786   321 SkGLGDt-IFTPLkeLVPGVEVHVQLTEQLIegnylqqPpllDDKIVTGFILFWL-----LLytl 379 Magnetococcus marinus
WP_012111430   330 AnGSLQl-HDTPLgiPLASGAIAANAIDQIAdgaflvrPgwaG---------VAE-----QVFVL 379 Parvibaculum lavamentivorans
jgi:Swit_1235  292 AeGTADi-VATPLeaEGYGTLVQAQAVDAILrggwldrPawaA---------PAE-----WGVGL 341 Sphingomonas wittichii RW1
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