Conserved Protein Domain Family
UNC-50

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pfam05216: UNC-50 
UNC-50 family
Gmh1p from S. cerevisiae is located in the Golgi membrane and interacts with ARF exchange factors.
Statistics
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PSSM-Id: 398749
Aligned: 91 rows
Threshold Bit Score: 134.934
Threshold Setting Gi: 557739595
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EAZ63974      75 MARRLFKPTTLDFETAIWEIFHLIINPKKMYRSHYYYKQqtsnnGKSSYTRDDPSFLILLTVFLSISAVAWGLAYSP-RV 153 Scheffersomyces...
EDQ51507      24 YLRRIVKYKQMDMEYTFWQMLHLCTSPKVVYQQTKYHKQ-----TKNQWARDDPAFVVICSFLLAVAATAFCAAYGH-SV 97  Physcomitrella ...
XP_001420594  15 YFRRAFRWRQMDVEYSLWQAASMCVNPKAVYRHTTYRKQ-----TKNQWARDDPTFVVMSCVFVTVAAIGYCAMYGG-GG 88  Ostreococcus lu...
Q00Y72        41 YLRRAFRWRQMDVEYSLWQAAAMCVNPKAVYRHTTYRKQ-----TKNHWARDDPTFVVLSCVAVGLAAIGWCAAYGD-GG 114 Ostreococcus tauri
XP_003054963  10 YLRRAMKWKQMDLEYAMWQMWLMCTNPKVVYRHTMYRKQ-----TKNQWARDDPAVVVLTSILVFATSSLYCCFFSK-SF 83  Micromonas pusi...
XP_002503978  24 YVRRLMKFRQMDLEYTFWQMYLMCTNPKVVYRHTMYRKQ-----TKNQWARDDPAFVVLTAIMVFAVSILYCLFYSR-SL 97  Micromonas commoda
Q54DD7        33 YFRRIFHYPQMDIEYTFWIMFYLCFNPSRVYRVTSWHKQ-----TKNQWARDDPAFAVILVFFMAIASMSYAITFHFlSF 107 Dictyostelium d...
EWS76671      65 HFSKFFQMSVEEIKSSFEEMSLLLFNIKRIVQLFQWNQQ-----IRHKWGRNNPSFLFLLVILQINIAVCYSLFIKQ-SL 138 Tetrahymena the...
ESS35483      29 FCHRLAHLSLMDLQFSLAQFSLLLFSPRKVYEFASIRKK-----QKNYYARDDPGFLLLLFFFFLVTGVVYALAFSH-SA 102 Toxoplasma gond...
XP_001568494  19 FLRRAVQVEQMEMDSALSQMYSLCLKPSLVSKMSRARKM-----TKGHYYRDDPAFLMLQLVFIVVVSVAQWLLL---GM 90  Leishmania braz...
EAZ63974     154 WD-ILKLIVYMVFIDFYLTGIVIATVSWFVTNKLFNntygnlggmNKY---------------------------NLNYI 205 Scheffersomyces...
EDQ51507      98 AQ-ATFTVVSVVFMHFFLVGVSLASICWFLSNHYLR---------EEFtvh---------------------thvVEQRV 146 Physcomitrella ...
XP_001420594  89 ASaTARIAARCAVGDYLGLGCVLATVSWYLANTYLR---------TKHmggh--------------------shaVEQRV 139 Ostreococcus lu...
Q00Y72       115 TSgSARVVARCVIGDYLGVGAVLATVSWHLANTHLR---------TKLpggh--------------------shaVEQRV 165 Ostreococcus tauri
XP_003054963  84 KH-SVYVVASAGLIDYVGLGALIATGYWFVSNRFLR---------TGVghs----------------------haIEQRV 131 Micromonas pusi...
XP_002503978  98 GQ-AAYAVVRSVLVDFLGVGAGVATAYWYVANRYMR---------EGVnhs----------------------haVEQRV 145 Micromonas commoda
Q54DD7       108 LN-VIKVMFWAVFVDFITVGLLIATIGWWVTNKFLR---------VSVhn-----------------------hsVDQSV 154 Dictyostelium d...
EWS76671     139 SE-YLTCIYKLL-AQFLIYGLIFTILPRLIVTRFLM---------KSE---------------------------VENHI 180 Tetrahymena the...
ESS35483     103 VGfLFTSLAPPVY-------LLLSALIFPFLHYVFL---------RCRprpshsrlrsshssrsregrhlapsssAGPRP 166 Toxoplasma gond...
XP_001568494  91 SR-SLVGILFSAIAWYVLSGLGMACVWRAVAVMYLS---------PSStsthggvltgat----salgvdsvvdyLRPDL 156 Leishmania braz...
EAZ63974     206 EWGFCFDIHCNSFLVIWCLLYLVQFLLLPLIRIRRsFLSILLGNSLYFGSIGYYFVITFYGFNSLPFISSNVrttsaagg 285 Scheffersomyces...
EDQ51507     147 EWLYAFDVHCNAYFPLYVVLYVLQYFLSPLLLAHG-FVATLLSNTLYFVALSYYHYLNFLGYDVLPFLERTT-------- 217 Physcomitrella ...
XP_001420594 140 EWMYAFDVHCNAFAPTYVVLYVLQLLLSPLLRRSG-YLASACSCVMYAIALAYHNYCVFVGYNALPFLERTE-------- 210 Ostreococcus lu...
Q00Y72       166 EWLYAFDVHCNAFVPTYVLLYVVQLTLSPLLRAEG-RLASALSCALYAVALVYHNYCAFIGYNALPFLENTE-------- 236 Ostreococcus tauri
XP_003054963 132 EWLYAFDVHCNAFFPLFLQLYAAQLVLSPVLLAGG-FIPRMLSCALYAVALGYYQYCTFIGFNALPFLE-AM-------- 201 Micromonas pusi...
XP_002503978 146 EWMYAFDVHVNAFFTLFVSLYCGQLVLSPILMMNG-FLPRLLSGALYGVALSYYHYCVFCGYNVLPFLEHTA-------- 216 Micromonas commoda
Q54DD7       155 EWLYAFDIHCNSFFPLFIILYVVQFFLLPILLSNS-LFAAILSNTLYIIGFSYYYYVTFLGYNALPFLQHTV-------- 225 Dictyostelium d...
EWS76671     181 SYIYSLDVFLNAYFVFLVFNYICLLILTPFWKNSNsFLIVIISSTLNLFANYRFYYIFFKFYSILPDVKKIE-------- 252 Tetrahymena the...
ESS35483     167 ELLFCFDVHWNASFLYLVFGLILYLVLLPLLrllplTLEVLLANSVQVVGLTAYCYITALGYARLGFSDSSL-------- 238 Toxoplasma gond...
XP_001568494 157 DWRYAFDVHCNGYFTFFIWTEVIAYFLAPVM------SVSWVSNAVVSIGTTTYLYSVFLGYLEIPSLSYQQ-------- 222 Leishmania braz...
EAZ63974     286 mfsntnnnparllqliVIAGILPVLALGWIISLIFRFNVADAMVDTYF 333 Scheffersomyces stipitis CBS 6054
EDQ51507     218 ----------------FFLYPIGLLALLFPISLLTGFNPSRFALGLYF 249 Physcomitrella patens
XP_001420594 211 ----------------FFLYPAALVLVLAPFAALVAFNPTRFVLWLYF 242 Ostreococcus lucimarinus CCE9901
Q00Y72       237 ----------------FFLYPAAAALIAAPIAALIAFNPTRFVLSIYF 268 Ostreococcus tauri
XP_003054963 202 ----------------LFLYPIAGVAFLAPMMCLFGFNPTKFVLGIYF 233 Micromonas pusilla CCMP1545
XP_002503978 217 ----------------LLVYPIALIMLVTPLAILVGFNPTKFVLGIYF 248 Micromonas commoda
Q54DD7       226 ----------------VFLYPIGILFALYIVSVVMGKNLTVSIINFYF 257 Dictyostelium discoideum
EWS76671     253 ----------------SFLIPIGLQVAINIIMVISNHNYYLFMINYFL 284 Tetrahymena thermophila SB210
ESS35483     239 ----------------PFFLPALLFLVVATVATVFSVNLGDILVSSLL 270 Toxoplasma gondii VEG
XP_001568494 223 ----------------RLLYPVLIVGVLFLLLSFSDINVGVKLWLQqc 254 Leishmania braziliensis MHOM/BR/75/M2904
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