2I9I,3BGH


Conserved Protein Domain Family
NLBH
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pfam05211: NLBH 
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Neuraminyllactose-binding hemagglutinin precursor (NLBH)
This family is comprised of several flagellar sheath adhesin proteins also called neuraminyllactose-binding hemagglutinin precursor (NLBH) or N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunits. NLBH is found exclusively in Helicobacter which are gut colonising bacteria and bind to sialic acid rich macromolecules present on the gastric epithelium.
Links
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Statistics
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PSSM-Id: 398747
Aligned: 6 rows
Threshold Bit Score: 258.98
Threshold Setting Gi: 2497717
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2I9I_A         2 SLETKTPndaknqvQTHERMKTSSEHvTPLDFNYPIHIVQAPQNHHVVGILTPRIQVSDNL-KPYIDKFQDALINQIQTI 80  Helicobacter py...
WP_013890113  24 GSNAESNggk--pnQKSASVKKAVGD-IPLKFYYPVNIDQESPNHRVVGILAPHVQVSGNL-SPYIDQFQDALVGQIQAI 99  Helicobacter bi...
CCB79308      27 GTKTSQA-------KKHATFQKNA---TPLDFNYPIDIRQEEANNHTIAILTPHIQADENV-QPYIGQFQNALVKQVQEI 95  Helicobacter bi...
CBY82683      27 GSTATNSq------KKRAIADKKIKDsTSLNFNYSIDIAQEEPNNHTIAILDPHIQADENV-QPYIQKFQNALIKQVQEI 99  Helicobacter fe...
P55969        20 svvallvgcsphiiETNE---------VALKLNYHPASEKVQALDEKILLLRPAFQYSDNIaKEYENKFKNQTALKVEQI 90  Helicobacter py...
3BGH_A         1 -----msldgmpakQQHN----NTGEsVELHFHYPIKGKQEPKNSHLVVLIEPKIEINKVIpESYQKEFEKSLFLQLSSF 71  Helicobacter py...

2I9I_A        81 FEKRGYQVLRF--QDEKALNAQDKRKIFSVLDLKGWVGILEDLKMNLKDPNNPNL--DTLVDQ------SSGSVWFNFYE 150 Helicobacter py...
WP_013890113 100 FQKRGYQVMRF--TSGQVLTPAQKHQMWSVLDIGGWVGILEDVKMDTKDPSKQDM--DVMVDQ------SSGSVWFKFFE 169 Helicobacter bi...
CCB79308      96 FEKKGYNIIHL--ASAQNLTPEQKSKIYSIVKIRGWIGILVDADINTDNPEDTDM--NTTVDQ------SAGAVLFKFFE 165 Helicobacter bi...
CBY82683     100 YQKKGYNIIRL--ASAQNLTPEQKNNIYTILKIRGWVGILEDADINTEHPEDTNM--KSTVDQ------SAGAVLFKFFE 169 Helicobacter fe...
P55969        91 LQNQGYKVISVdsSDKDDLSFSQKKEGYLAVAMNGEIVLRPDPKRTIQKKSEPGLlfSTGLDKmegvliPAGFVKVTILE 170 Helicobacter py...
3BGH_A        72 LERKGYSVSQF--KDASEIPQDIKEKALLVLRMDGNVAILEDIVEESDALSEEKV-----IDM------SSGYLNLNFVE 138 Helicobacter py...

2I9I_A       151 PESNRVVHDFAVEVGTFQAMT-----YTYKHnNSGGLNSSNSIIHEY----------------LEKNKEDAIHKILNRMY 209 Helicobacter py...
WP_013890113 170 PETGRIIHNFGIEVGTEQAITh---tYTYQAtDSGGFAGANTISHTE----------------LEKNNDNAIRKILNQMY 230 Helicobacter bi...
CCB79308     166 PKTGRTTHNFAINVGAEHAITy---sYFQEAtSSDSFAGANSVSRGAtsldsfde-anavggrVDKNHHDAIQTILSKAY 241 Helicobacter bi...
CBY82683     170 PKTGRTTHNFAINVGAEQAIThphlsYFQQA-NSDSFAGANSISRGAtsldsfdeasldsrnhTDSNHDNAIHTILNQVY 248 Helicobacter fe...
P55969       171 PMSGESLDSFTMDLSELD--IqekflKTTHSsHSGGLV-STMVKGTD-------------------NSNDAIKSALNKIF 228 Helicobacter py...
3BGH_A       139 PKSEDIIHSFGIDVSKIKAVIe---rVELRRtNSGGFVPKTFVHRIK-----------------ETDHDQAIRKIMNQAY 198 Helicobacter py...

2I9I_A       210 AVVMKKAVTELTKENIDKYREAIDRMK 236 Helicobacter pylori
WP_013890113 231 VIVMKRMVEELTSENIDRYRDAIEKIK 257 Helicobacter bizzozeronii
CCB79308     242 GVVVKKIVSWVQNADLKQYRKAIDQIR 268 Helicobacter bizzozeronii CIII-1
CBY82683     249 GVVIKKLIDWVEGADLKQYRRAIDQIR 275 Helicobacter felis ATCC 49179
P55969       229 ANIMQEIDKKLTQKNLESYQKDAKELK 255 Helicobacter pylori 26695
3BGH_A       199 HKVMVHITKELSKKHMEHYEKVSSEMK 225 Helicobacter pylori 26695
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