Conserved Protein Domain Family
COMPASS-Shg1

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pfam05205: COMPASS-Shg1 
COMPASS (Complex proteins associated with Set1p) component shg1
The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes.
Statistics
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PSSM-Id: 398742
Aligned: 86 rows
Threshold Bit Score: 50.2532
Threshold Setting Gi: 1233646101
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK43794      24 HLTTIYKKNGNFDKQRKELLENFkESETCKNLLLKLQIMIESKVKHDP-LILIKnKGKMAALIQGEIVNQrsgsHSLSnn 102 Lodderomyces el...
XP_015793131   7 KIVNDLKARGVFDEFRKECLSAVdTRPAFENLRQKIDGKVKNYLESLTwDASLN-RNQLREKLRRSLTES----DNVI-- 79  two-spotted spi...
XP_018671965  10 RIVERLKTNGIFDEMRRDCLADIdTRPAFQNLKLRIENYVTSLLSAEVwTPTLN-KNQLRSKVRMSVMQS----GMLN-- 82  vase tunicate
Q68FB1        34 lIVEQLKSRGQFDGFRRDCLADVdTKPAYQNLRQKVDNFVSTHLDKQEwNADMN-KNQLRNGLRQSVIQS----GMLE-- 106 tropical clawed...
Q8IYS8        41 iIVGQLKSRGLFDSFRRDCKADVdTKPAYQNLSQKADNFVSTHLDKQEwNPPAN-DNQLHDGLRQSVVQS----GRSE-- 113 human
Q08CT1        24 lIVEHLKNKGHFDEFRRDCLADVdTKPGYQNLQQRVGTYVSTHLSTQEwNPTIN-KNQVRNALRQSVIQS----GMLE-- 96  zebrafish
Q4RRX6        25 mIVEHLKNRGLFDEFRRDCLADVdTKPAYQNLRQKVDNFVTSHLSTQDwNPSIN-KNQMRNGLRQSVVQS----GMLE-- 97  spotted green p...
2_pfamImport   1 -IVNHLKSQGLFDQFRRDCLADVdTKDAFEMNLYCFENFLGNQKETHKwELKKN-KNKYCS-IKQQVARS----GMLE-- 71 
XP_001635176  25 QIVDHFKRQGNFDELRRDCLDELdKMESFRQLNQRVESYVATFLSKQDwSDSLP-KNQVRNSLRKHVNES----DALK-- 97  starlet sea ane...
AAI53356      14 QIVNHLKSQGLFDQFRRDCLADVdTKPAYQNLRQRVDNFVASHLASHTwSPHLN-KNQLRNNIRQQVLKS----GMLE-- 86  tropical clawed...
EDK43794     103 nttdkgtgvslsekesytqdsngpsNTILGIVDRDIqekiiesEEFQFAIKEE 155 Lodderomyces elongisporus NRRL YB-4239
XP_015793131  80 -------------------------ATIQHLVDQVIa------QKATTYMLSR 101 two-spotted spider mite
XP_018671965  83 -------------------------TGVEYILHQVVd------SKMYSEFLPK 104 vase tunicate
Q68FB1       107 -------------------------AGVDRIISQVVd------PKLNHIFRPQ 128 tropical clawed frog
Q8IYS8       114 -------------------------AGVDRISSQVVd------PKLNHIFRPQ 135 human
Q08CT1        97 -------------------------SGVDRIISQVVe------PKLQHIFRPI 118 zebrafish
Q4RRX6        98 -------------------------SGVDRIITQVVd------PKMNHTFRPQ 119 spotted green pufferfish
2_pfamImport  72 -------------------------SGVDRIISQVVd------PKINHTFRPQ 93 
XP_001635176  98 -------------------------TGVDRLVSQALe-------RKRKSFQMR 118 starlet sea anemone
AAI53356      87 -------------------------SGIDRIISQVVd------PKINHLFRPQ 108 tropical clawed frog
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