2O8F,2O8D


Conserved Protein Domain Family
MutS_IV

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pfam05190: MutS_IV 
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MutS family domain IV
This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with pfam01624, pfam05188, pfam05192 and pfam00488. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds in part with globular domain IV, which is involved in DNA binding, in Thermus aquaticus MutS as characterized in.
Statistics
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PSSM-Id: 398730
Aligned: 43 rows
Threshold Bit Score: 59.158
Threshold Setting Gi: 74661387
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2O8F_A  473 SFDPNLSELREIMNDLEKKMQSTLISAAR--DLGLdpgKQIK---LDSSAQFGYYFRVTCKE----EKVLrn-nkNFST- 541  human
P40965  447 DSNGLLDVSRQIYKEVKEEFFREVEDLTA--KNKI----NLD---HNYDSARGFYLRIKRQEftddVATLp---dVFIS- 513  Saccharomyces cerev...
Q6FUM7  460 eSNSLLGTLRSLYSKISEEILNDISCFGE--KHCIhasPNFR---TG----VGFFIKVSDSD----YIKIeknrvNIIN- 525  [Candida] glabrata
Q19272  449 GIDEELDEIRDTYENMPMVLTAIAKQEEA--RLGLppySNVA---CVYIPLVGFVLSVPRDY----GVESq---pDMTL- 515  Caenorhabditis elegans
O43196  398 NIDPEIDEKKRRLMGLPSFLTEVARKELEnlDSRI---PSCS---VIYIPLIGFLLSIPRLP-----SMVea--sDFEIn 464  human
Q9N3T8  767 GCDEEYDEALNRVKEALNELNDYKDSVAK--KYSC----SIK---FVDSGKVKYLLEMP-EN----TKVSs----SFEL- 827  Caenorhabditis elegans
Q9VUM0  767 GMDAEYDAAMDSIGEVEKRLKTYLVEQER--HFGC---RITY---FGSDKKR-YQLDVPESH----ASKAnk--sYTLE- 830  fruit fly
Q03834  780 GFDIEFDKSMDRIQELEDELMEILMTYRK--QFKC---SNIQ---YKDSGKEIYTIEIPISA----TKNVp---sNWVQ- 843  Saccharomyces cerev...
2O8D_B  594 GFDSDYDQALADIRENEQSLLEYLEKQRN--RIGC---RTIVywgIGRNR---YQLEIPENF----TTRNlp--eEYEL- 658  human
O04716  886 GADEEYDCACKTVEEFESSLKKHLKEQRK--LLGD---ASIN---YVTVGKDEYLLEVPESL----SGSVp---hDYEL- 949  thale cress
2O8F_A  542 -VDI--QKNGVK---FTNSKLTSLNEEYTKNKTE 569  human
P40965  514 -RTI--KKNYIE---CTTLNIIKKNARLKEVMEE 541  Saccharomyces cerevisiae S288C
Q6FUM7  526 -KVN--KRGHVE---FTTLPLTKKNIRLNTLITe 553  [Candida] glabrata
Q19272  516 -LYS--THEDLR---VRNATTSRLDDEFGDILMR 543  Caenorhabditis elegans
O43196  465 gLDF--MFLSEEklhYRSARTKELDALLGDLHCE 496  human
Q9N3T8  828 -KSR--RKGFIR---YSTPDSEQLVAALDAVEKE 855  Caenorhabditis elegans
Q9VUM0  831 -GQTkgKKPSRR---YTTAETRALLKDMQHAEDT 860  fruit fly
Q03834  844 -MAA--NKTYKR---YYSDEVRALARSMAEAKEI 871  Saccharomyces cerevisiae S288C
2O8D_B  659 -KST--KKGCKR---YWTKTIEKKLANLINAEER 686  human
O04716  950 -CSS--KKGVSR---YWTPTIKKLLKELSQAKSE 977  thale cress
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