2QGM,3B55


Conserved Protein Domain Family
Erythro_esteras

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pfam05139: Erythro_esteras 
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Erythromycin esterase
This family includes erythromycin esterase enzymes that confer resistance to the erythromycin antibiotic.
Statistics
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PSSM-Id: 398692
Aligned: 164 rows
Threshold Bit Score: 124.385
Threshold Setting Gi: 586957716
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2QGM_A                101 VTEXGFTNFAXEEDWGNGLKLNEYIQtgkgnprEF----LKLLYPTDEIIAXI--EWXKDYNAdpsNKKKIQFIGLDLK- 173 Bacill...
ADC51686               66 HQHHGFNVVVLESGLLEATLCKEFLtnlspd--kqiqetLLDIYHNEEMKPLFeeEWAQS----------IKLSGMDPQp 133 Bacill...
WP_013765668           85 HQEMDFDVLVIEGGFGDINLAWLNQgeqdak--almynsVFGNFRNEEMLPLF--EYAKAQAasa---dpLVLAGPDCQa 157 Halisc...
PRJNA194094:J421_0572 292 HEALGYDVIAFESSLFACDRVGRKAdslsam--elmrgcIFGVWHTNEVLPLF--EYIKETQrta---hpLVLTGFDVQr 364 Gemmat...
O31455                 93 HEELGYDVLAFESGFPDTNASYLNMdqltpk--stmknsIYAVWHTEDVVELF--DYMKEQKekg---dpLILTGFDIQ- 164 Bacill...
WP_012819343          124 HQEMGYNVLAFESGLGNSSLAYGRAgqrsae--qtmkdsIFGVWWSKEIMPLF--DYIKTAQqsk---qpLVLTGFDMQl 196 unclas...
jgi:Sgly_1314          78 VANNGCRTFIIEGDFGGALKVDAYIHgaegtakDVvgeiGFNIYHTHEMANLV--DWMRSYNKdapEGKDLHFYGMDIQ- 154 Syntro...
jgi:Runsl_2776         94 VQQHGLRTLALEVHFAAGQALDKYIKsgtgdlkQIlhnsGYWIYTTREFAVLI--NWMKAYNVgkaPEQQLSIYGIDAQp 171 Runell...
WP_002990769           84 VKNKGLKVFIMEESYQAEAGINEWIKggqgdkkTIgnnfKLIFWSTPEVIDLL--EWMRNYNMekpEEEQIRFYGMDMQs 161 Myroid...
jgi:Ftrac_1888         77 VEEHDYNTIFLEEDYATCLRVDNYIKgaednpiEVvksfNQWPWMTQEMADLI--EWMREYNSdkkNEQ-LSFVGIDMQy 153 Marivi...
2QGM_A                174 -A----LDQGSfNKVI-------------------DYVRLH--R--PDLLAEVEENYKELSSFtgSiqe----------- 214 Bacill...
ADC51686              134 ------tYPLVsEYMV-------------------EWVKTHvdD---ELYHSMKKAEEQYFEFqdE-------------- 171 Bacill...
WP_013765668          158 ------sSNYFnNFLI-------------------DFLRKY--D--ADLSRDVEYNFMNTFLLygL-------------- 194 Halisc...
PRJNA194094:J421_0572 365 sgdgdreRSTFlRRVV-------------------ATL-----D--TAYARRVYATDSAFYATmpT-------------- 404 Gemmat...
O31455                165 -S----MKNSFnVAAT-------------------QWVKAV--D--PEKAELLSQSENDFSTLvtD-------------- 202 Bacill...
WP_012819343          197 qH----Pll------------------------dgQWLQD------QAMAKRLSEAEKKLSDYslG-------------- 228 unclas...
jgi:Sgly_1314         155 -R----YDNNK-EYLF-------------------SVLDVA--A--PALSKKYKS----L-----Sqltd---------- 186 Syntro...
jgi:Runsl_2776        172 qG----AKGSV-TALR-------------------AFFEKN--D--PTYLTAYDGLTKSIADGfpEfnavts-------- 215 Runell...
WP_002990769          162 -------GHKInLEIR-------------------DFVSLNklT--------VDEDLLVVADScsTkeidyykpsdwwql 207 Myroid...
jgi:Ftrac_1888        154 yK----TTLDLiDSILianssalkneltvsettneQFMTKSdtDgiEKFENIVKERQAAIENIdlS-------------- 215 Marivi...
2QGM_A                215 ---------yxKLtpkLKEKFKANA---ERVARL-------LKDENEq--------------------ANTEIIPSEYIW 255 Bacill...
ADC51686              172 ------------LlfkITKPLKRKMkksIQDYEDlld-llaIKQMREktpeiq---------kmllliERGMQNRLQWLQ 229 Bacill...
WP_013765668          195 ------------------KPDSTQLmqaIRTNERvisrvmdFLENNEsrlredypq----kpllvpfvRRALENYLEYWS 252 Halisc...
PRJNA194094:J421_0572 405 -----------GNgpaVSPADRDRL---VAFYDSla----aWIRARErplaksfr-----ddpiapalARQTAISMSFFA 461 Gemmat...
O31455                203 -----------SNtfdEFSQKKEKL---VKNYQKli----kFTKTHAselkenlpkepkayemfmhslQLRIDVMETYML 264 Bacill...
WP_012819343          229 ------------MdldAYRKEKHQL---IQVYKDale--slKTEANEahlkrlypdnpklsmllertlNDRIRVAREYVE 291 unclas...
jgi:Sgly_1314         187 -------etrlTLsadVLYKSKTDV---LGLLKE-------MDASKAdi-----------------aaISGQTA---FDF 229 Syntro...
jgi:Runsl_2776        216 ------qeeavKLapaYSQLLVGKI---DRIQQY-------LVQKQAql-----------------aaAPG------YAI 256 Runell...
WP_002990769          208 qtpklqqlkeqILhsnLEKEKYQTI---ERALNY-------LISYTE--------------------------------- 244 Myroid...
jgi:Ftrac_1888        216 ------------------ETVENKLkhlTRGLKFi--------------------------------------------- 232 Marivi...
2QGM_A                256 AKATASAIEKFTTXLL-PNDYPsiiklHEQYLADHAXWAQEt--FGGKTXVWAHNIHIA--KGIIDEKLyP-----YVAG 325 Bacill...
ADC51686              230 VNLKGYVASgv---------------qRGLHMFQNLEWLMKhyyKEEKLIVWAHNFHIRkkrpil-----akalgiKSVG 289 Bacill...
WP_013765668          253 LNYRAMSLQqqf-------------vlRDRIMAENLMWLADvayPNKKIIYWAHNAHIAteTIAVDIFGkPi---eKLQG 316 Halisc...
PRJNA194094:J421_0572 462 RELAAGVATegt-------------vvRDRGMADNLDFVLDelhPRKKVIVWAHNFHIQhrgfapr---aapsvpvRTMG 525 Gemmat...
O31455                265 EEMKEKLEEy-----P-ENIEDfsffmRDRMMAEQFQWVADtlyPKKKIIVWGHNYHLR--KQNTKMIKdWvqlngPNMG 336 Bacill...
WP_012819343          292 LSIQSTLGMes---gD-YVPFLesmewRDQAMHDNLMWLATevyPTEKFIVWGHNDHIR--KAQTEVMGtPyp--vTLMG 363 unclas...
jgi:Sgly_1314         230 ARESANTIYECSEILlsNN-SDyn-slRDKYMSEKVNWFLQhrd-dsvLFINGHNGHIGk----------TstsgyTCLG 296 Syntro...
jgi:Runsl_2776        257 ALKHAQVLQLGMTQIg-LTDPDdglgfRDEYMADNVAWVnt-qaVGTKVMVFAHNGHIN--THRSTGIRkEv----SWMG 328 Runell...
WP_002990769          245 ---YATTIK---------EKYPtstefRDLKMFENVKYIVDqqaENEKVFIWAHNEHINkkEMYYTGSDi------INLG 306 Myroid...
jgi:Ftrac_1888        233 --------------vE-EKHNLdngayRDVKMAENILAHFEe-aPKTKGVFWAHNGHIL--TACSDKSVsK-----CRAG 289 Marivi...
2QGM_A                326 QFLKERLDNNYVTIGSTTTEGNFTLYSey---------nPSTGGKITTDTIPQDVKSF-------NYTLGKVPykxflld 389 Bacill...
ADC51686              290 YWLEKKYPEDIYAVGLYAGSGTFATQLrvnlgihmkkkqSHL-----------------------ESLLYEAKeadlflp 346 Bacill...
WP_013765668          317 NYIFERFGAQVYNIGLYATGG-------------------ELFHHMLREVKPFKDDSIggigahfSRLPKDINflelrgq 377 Halisc...
PRJNA194094:J421_0572 526 TYVAERHRKELYTVGLYMYRGs-----------------GAMNNRQVYPIAPATAGTL-------EAIVHQAPwrytfvd 581 Gemmat...
O31455                337 DYLPERLKKQTYTIGIYAYSGas--------------ldSSDNKTVKPVTSPPPSGSL-------EALLKAADrpavfvd 395 Bacill...
WP_012819343          364 EKLSDEMKKYSYVLGLYPASGq-----------------TADNMGNVHDVLPAEPGSM-------ESILSAAGspytfvd 419 unclas...
jgi:Sgly_1314         297 ELLTKDIGKSYFAIGTDAEDTEFNSQDn------------nGNF-SVMEVKNR--NEL-------NSLLYNVErnfyyid 354 Syntro...
jgi:Runsl_2776        329 NHLRKKFGAEYYATGFLFNEGSFRVSGp--------------tGLYTATVKPKADSPL-------TQAFAGLGqtpfffd 387 Runell...
WP_002990769          307 RHLKEYYQDDYYSVGFDFGTGSIKGYVtd---------kKKEPYWKTYHITKPFPNTY-------AKVLMAVDkpvffid 370 Myroid...
jgi:Ftrac_1888        290 ANLKDKMGNEYFAIAFDFDKGAFNAYYlsnnegdqndrdNY--KLGEVAVDSAPDGFI-------ASRIRNNYnsvvfip 360 Marivi...
2QGM_A                390 nrhlkgqaek--------------wvkakrpllsiggqilpNSsvyfdtsLLEQFDIIFHIRKT 439 Bacillus cereus ATCC 1...
ADC51686              347 ltgnkdqkwlrr--------------------rwrllesgfsglspmivqPQKHYDAIMFIREA 390 Bacillus pseudofirmus OF4
WP_013765668          378 kpgkgkdwlf-----------------------kaipafelenggkiqmtPSKRFDALIVVKKV 418 Haliscomenobacter hydr...
PRJNA194094:J421_0572 582 lsrategpgtaw--------------------mfrpllarewgtntlsivPRDEYDGILLVDTT 625 Gemmatirosa kalamazoon...
O31455                396 flhtknkkgtsw--------------------mytprtalywgymeeqmiLKEQYDGVIWLEHI 439 Bacillus subtilis subs...
WP_012819343          420 lryqkreagnsw--------------------mfeprfayswgmipesliARDQYDGILLIDDV 463 unclassified Paenibaci...
jgi:Sgly_1314         355 fskviddenwqklldgqqkittlnvgisgwqkllksfytttIV-------PNDTFDGMIVFKKV 411 Syntrophobotulus glyco...
jgi:Runsl_2776        388 latvnrspglkaile-----keyffysaaasyagedsagqfYT-------LPTAFDGLIFVAKT 439 Runella slithyformis D...
WP_002990769          371 medsyrneptsfftkks----------kylmiggggyqpkplhrilinkiYYEAYDGLIFVKEI 424 Myroides odoratus
jgi:Ftrac_1888        361 kesfenrkdr--------------klagrfvgakftnyskeGSqpysekwYIRQFDAIIIIKNT 410 Marivirga tractuosa DS...
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