5APA


Conserved Protein Domain Family
Asp_Arg_Hydrox

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pfam05118: Asp_Arg_Hydrox 
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Aspartyl/Asparaginyl beta-hydroxylase
Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyze oxidative reactions in a range of metabolic processes. Proline 3-hydroxylase hydroxylates proline at position 3, the first of a 2-OG oxygenase catalyzing oxidation of a free alpha-amino acid. The structure of proline 3-hydroxylase contains the conserved motifs present in other 2-OG oxygenases including a jelly roll strand core and residues binding iron and 2-oxoglutarate, consistent with divergent evolution within the extended family. This family represent the arginine, asparagine and proline hydroxylases. The aspartyl/asparaginyl beta-hydroxylase (EC:1.14.11.16) specifically hydroxylates one aspartic or asparagine residue in certain epidermal growth factor-like domains of a number of proteins.
Statistics
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PSSM-Id: 398678
Aligned: 115 rows
Threshold Bit Score: 72.6677
Threshold Setting Gi: 505215128
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5APA_A                 59 IRDEGLAvmdkak-glflpEDENLREKGd----------WSQFtlWQQG---------------RRNENACKGAPKTCTL 112 human
XP_013941341           16 VEMDVLHamegevssasipYETVYREFQsg--------gWQTAllYTPEggnedg---tvrdgaAIPTELVRKLPAVYQF 84  Tricho...
Q92LF6                 16 LAEDLSTlev-------aeFSSAYSDFAcg--------kWEACvlRNRTgmqeedi-vvshnapALATPLSKSLPYLNEL 79  Sinorh...
WP_015402230           16 LDDDLAYpaav------prveEEYDEFSsg--------yWKNLslANSSgqaddta-yvdidgsALTTEHGKNTPYLSEL 80  Coryne...
jgi:Fluta_2431         21 LVSDLKRamege--wishfNTGGYTGN------------WKAVslYAANgneqnifahlqdytsISETPLMKECAYFKEV 86  Fluvii...
CBA16590               83 IRAEAISlhqsg--qlretSQPGSAGFHdlgfrtfykhgWMKFylKWYG---------------KTHRSAIRLCPETTRI 145 Xantho...
calssnu:BYI23_D014470  74 IRSEAIAlhea-------skiqAAGVYNdigfnsffrrgWRRFylKWYD---------------RPHPSAVAQCPKTVSI 131 Burkho...
Q13I30                 74 IRDEAFAlrda-------shirAATAYNdigfnsffrngWRRFylKWYG---------------RPHPSAVALCPRTVEL 131 Parabu...
jgi:Mpe_A2325          75 IRDEALKlnde-------gqirAAASYNdigfnsffrtgWKRFylTWYG---------------KELSSANALCPQTVAL 132 Methyl...
zhongguo:B5T_04046     72 FRDEAMKlfde-------gyirQAASDNdlafhsffrtgWKRFylKWYD---------------DSQPSAEALCPRSVAL 129 Alcani...
5APA_A                113 LEK-Fp-eTTGCRRGQIKYSIMHPGTHVWPHTGPTNCRL--------RMHLGLVIPkEG--CKIRCANETKTWEEGKVLI 180 human
XP_013941341           85 LED-----L-GLDYFTVRIARNSPDSWLWEHRD--YNELaaqk-srlRLHVPLASS-PS--ALIHFDESAICMASGWIWK 152 Tricho...
Q92LF6                 80 VET-H---FDCSAVRYTRIVRVSENACIIPHSD--YLELdet---ftRLHLVLDTN-SG--CANTEEDKIFHMGLGEIWF 147 Sinorh...
WP_015402230           81 VNT-V---FDRDRVKMVR-ARNLIDAMVVSHRD--FVDLgedndryfRTFMVLEDN-PQ--AFHSDSDTVIRMRPGELWY 150 Coryne...
jgi:Fluta_2431         87 LNQ------FKCDILSARLLRLEVGAEIKPHTD---HELgyed-gqfRLHIPIVTN-PE--IEFILDGERLTMLPGECWY 153 Fluvii...
CBA16590              146 LEQlPwihG-------AMFSILPPGAELSLHSDPLACSL--------RYHLGLKTP-NSdnCKIIIDGRTMAWRDGQDFV 209 Xantho...
calssnu:BYI23_D014470 132 LQKvPtvkA-------AMFAMLPPGGVLTLHRDPYAGSL--------RYHLGLVTP-NDdnCAIIVDASAIHGATARKSF 195 Burkho...
Q13I30                132 LGRiPsvkA-------AMFAQLPPGGRLGLHRDPYAGAL--------RYHLGLATP-NHdgCAIVVDGETYSWRDGEDIV 195 Parabu...
jgi:Mpe_A2325         133 LKSiPsikA-------AMFASLPPGATLVRHRDPYAGSL--------RYHLGLTTP-NDpgCFIEVDGQRYHWKDGEVVM 196 Methyl...
zhongguo:B5T_04046    130 VNQvPsvnA-------AMFAMLPAGAKLGRHRDPFAGSL--------RYHLGLVTP-NDdrCAIYVDGEQHVWHDGKDVV 193 Alcani...
5APA_A                181 FDDSFEHEVWQDASSFRLIFIVDVWHP 207 human
XP_013941341          153 LNPTASHAISNTGLEPRTHLILDCYvn 179 Trichoderma atroviride IMI 206040
Q92LF6                148 LDAMLPHSAACFSKTPRLHLMIDFEAT 174 Sinorhizobium meliloti 1021
WP_015402230          151 LDAAAVHSAVNFSSQSRQSLCVDFIfd 177 Corynebacterium halotolerans
jgi:Fluta_2431        154 TNVNFVHSVANRGTIDRVHLVIDGVRn 180 Fluviicola taffensis DSM 16823
CBA16590              210 FDETYPHSAINASDQDRVILMCDVERP 236 Xanthomonas albilineans GPE PC73
calssnu:BYI23_D014470 196 FDETYLHWAENKTDKDRIILFCDIERl 222 Burkholderia sp. YI23
Q13I30                196 FDETYLHYAFNDTQEDRIILFCDIERP 222 Paraburkholderia xenovorans LB400
jgi:Mpe_A2325         197 FDETFIHHAANETQQQRVVLFCDVERP 223 Methylibium petroleiphilum PM1
zhongguo:B5T_04046    194 FDETFIHWAENNTDQDRLILFCDVERP 220 Alcanivorax dieselolei B5
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