Conserved Protein Domain Family
eIF-3_zeta

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pfam05091: eIF-3_zeta 
Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
This family is made up of eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta/eIF3 p66/eIF3d). Eukaryotic initiation factor 3 is a multi-subunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits. These functions and the complex nature of eIF3 suggest multiple interactions with many components of the translational machinery. The gene coding for the protein has been implicated in cancer in mammals.
Statistics
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PSSM-Id: 398661
Aligned: 95 rows
Threshold Bit Score: 361.175
Threshold Setting Gi: 75032595
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007412937  12 FVLPQINDHPD-AWGPSpTaLPAQ--FK-------DIP---YAPFSKSDKLGRVVDWNADlaqpnVGANgyprgnfrsqq 78  Melampsora lari...
XP_001018258   8 adlenlksFTKqTWGPDrNyvf--tkFD-------NLP---FTPFSRLEKLGACCDLQNImatrtGLKQ----------- 64  Tetrahymena the...
XP_004030408   8 qdlenlqiSQKqNWGPDpNykf--prFE-------NMA---FAPFSRLEKLGKCCDFANMmavrtGQKQiq--------- 66  Ichthyophthiriu...
Q5CPM5         3 KFNYILNFSPD-TWTPTiE----SkaGEnclggikNFP---FAPSMKIDRLGAVCDFSYT-------------------- 54  Cryptosporidium...
XP_001614386   3 AFKLIGVANNR-TWGPDsK---NEelVNqcmgelkKYQ---FEPSMKFEKIGKICDFTSS-------------------- 55  malaria parasit...
Q8IJW4         3 SFNLVGVINNR-TWGPDsK---NEelVNycmpdikKYQ---FEPSMKFERIGKVCDFTMN-------------------- 55  Plasmodium falc...
Q7RGS7         3 TFKLFGVVNNR-TWGPDiK---NEelVNscmedikKYQ---FEPSMKFEKIGKICDFTTT-------------------- 55  Plasmodium yoel...
Q4MYQ4         3 NLNIVANFNSN-GWGPDeE---DDqtINtclhtinKFP---FDPKLKLDKQIHICDFTFS-------------------- 55  Theileria parva
EDO07617       3 RLRIVTNLNAS-GWGPDeS---DDqtVVsslgslsKLP---LEPRLKFDRQLRVCDFTYF-------------------- 55  Babesia bovis
EFC42669       9 saislLEQSKE-GWGPI---HPASssVEqskseilSLPtnlFHIIPSKISIGKIADWTSEqsaptTSTTt---------- 74  Naegleria gruberi
XP_007412937  79 rgqgreN------YGA----Gq-aGTF-AYFH----------------DEDEASFNLVGGGasFSr-GGGgggLlgRGgg 129 Melampsora lari...
XP_001018258  65 ------TqvirstAPAnaptNtveSVQvTTTA----------------VDAENDFHTVTAKkdKN--LYAqkiI--KQ-- 116 Tetrahymena the...
XP_004030408  67 -----------------------sSNMpQLQQ----------------QQNNQ--------------------------- 80  Ichthyophthiriu...
Q5CPM5        55 ----------------------------SYSRgrda---------kssQADNQDFHLVDSRpfPKtkVRYvqrK---F-- 92  Cryptosporidium...
XP_001614386  56 ----------------------------SYQKnvkdank--nsnegnaFEDELQFQTVDLRagQKqkGPMygkKkiMN-- 103 malaria parasit...
Q8IJW4        56 ----------------------------SYQKntkdink--nsndvnaFEEELQFQTVDLRtgQKqkGSIfnkKkiHN-- 103 Plasmodium falc...
Q7RGS7        56 ----------------------------SYQKnikdinkn-sgdgdnaFEEELQFQTVDLRtgQKpkGTLfnkKkiIN-- 104 Plasmodium yoel...
Q4MYQ4        56 ----------------------------TYQRnaregnrl-nrvnstsMDEELQFQTVDSRtiVKikPTThykKktPI-- 104 Theileria parva
EDO07617      56 ----------------------------TYQKnirdagrygrqpvpvvVDEEMQFQTVDGRslMKakNMQhyrRkaVP-- 105 Babesia bovis
EFC42669      75 --------------------HsvaAAIaNVTG----------------AND--DFNLVVSNtqSQ--------------- 101 Naegleria gruberi
XP_007412937 130 rgrggnlrgTS-GRGRGMSDRndrggarggvgr-----rggqwgrgggtwKgDW---NDRNSR-TRESTVVVGPEWQVRE 199 Melampsora lari...
XP_001018258 117 ---------GL-RDQKINKQReqeqkeqeknski----qnvkkpkiisanN-KK---QVIIKT-KFKEYTNIKVDWEVLH 177 Tetrahymena the...
XP_004030408  81 ---------QQ-QQQVPLPEIpqeeeqysnsyvk----qpsrqrqkinpnK-TK---IVVIRT-KFKDSSNIQANWVLLT 141 Ichthyophthiriu...
Q5CPM5        93 ---------QKeTAQAYHQKQqqqekaemllrqgkr--sakmrqagtqqyqySRhrfVSRMRT-LTEWSIEPLSSWISVA 160 Cryptosporidium...
XP_001614386 104 ---------KQ-TTQAFAQKQeeennlyssrik------taeqkkqkllqQaKTarmNARHRI-FTEWSIEPTPVWTVEC 166 malaria parasit...
Q8IJW4       104 ---------KQnTTQAFTQKQqeednlyssrik------taeqkkqkllqQaKTariNARHRI-FTEWSIEPTPLWTVEC 167 Plasmodium falc...
Q7RGS7       105 ---------KQ-TTQAFTQKQqeednlyssrik------taeqkkqkmlqQaKTarlNARHRI-FTEWSNEPTPSWTVDC 167 Plasmodium yoel...
Q4MYQ4       105 ---------KQ-TTQAFNQKVmeeeqlqfskqk-----qypdlrrqkyiaKnRSlrlPTRYHP-LNEWSIEPTPAWNVVA 168 Theileria parva
EDO07617     106 ---------KQ-TTQAFNQKQmeeeamimsakq------khpemrkqrmmHsRGnrpTARHHT-FNEWSIEPSHSWHLLS 168 Babesia bovis
EFC42669     102 ---------RK-SYTNYNQNKrrpttqsqppkaaynqeqnkqnkqkkkkaTlSY---YQKTKTqNYKPSIKVKKSWVLID 168 Naegleria gruberi
XP_007412937 200 EIEFTRLAKLRl-------EVDidE-VQDMlsivplasqlairkltyASYGFLYEYDRVYDRINTKNPQPLQI--LDRSR 269 Melampsora lari...
XP_001018258 178 ESQKLNIEQHPi------nNVT----ITPI-----------------KITGKLKQYEKAFDRID---PRGIKKldASKNL 227 Tetrahymena the...
XP_004030408 142 ESQKINIEQHPi------kEVK----FTEL-----------------ECTGTLKKYNRSYDKID---PRYIKKveCNQTV 191 Ichthyophthiriu...
Q5CPM5       161 EIPLSSLPKQFl-------DVSksT-IEDI-----------------GWFGTLKSYNKSMDRISPKLPMVLKDfgNME-F 214 Cryptosporidium...
XP_001614386 167 EVMFNELPKKLi-------KMEnfQ-MQDI-----------------YFRGRLLYYDKKFENINVKSPPGLVNqsKDSIN 221 malaria parasit...
Q8IJW4       168 EIMFNELPKKIi-------KIDnlK-VEDL-----------------FFKGKSLFYDKKIENINVKNPPLLFHhtKEGIN 222 Plasmodium falc...
Q7RGS7       168 EIMFNELPKKLi-------KIDhlK-IEDI-----------------FFRGKVLYYDKRFENINVKNPPFLAHlnKDANV 222 Plasmodium yoel...
Q4MYQ4       169 EIPFNILLKQEm-------DSSqvT-VEDL-----------------FWRGKLGIYDRKMDQITPKNEVYLLHlsNSYDY 223 Theileria parva
EDO07617     169 DIPFSQLSKv---------DLPgkVvGTDV-----------------TWRGKLGVYDKRMDHISAKSEVPLQNlnDQFDY 222 Babesia bovis
EFC42669     169 KFLFGTLKKATteplesgkGYKtpE-PIDR-----------------HICGSLGYYDKKFDRASAKQPLTLEKpqKLNGY 230 Naegleria gruberi
XP_007412937 270 YHP--TASEDPVIQDLAAr-N--------------------------------------------------------KAR 290 Melampsora lari...
XP_001018258 228 SVVnsSTLKDDILIELLQq-Dvde--------------------------------------------------ksdKPT 256 Tetrahymena the...
XP_004030408 192 ILPsaSSLKDPVLIRLLEe-Dlen--------------------------------------------------kiqKPT 220 Ichthyophthiriu...
Q5CPM5       215 LQP--TTSDDEILRDALLqpEr-------------------------------------------------------NID 237 Cryptosporidium...
XP_001614386 222 LVC--KTMDDQSLMEILLdeDkkskaaaav---------------------------------------aedgvnssNII 260 malaria parasit...
Q8IJW4       223 LIP--KTKEDHNLINILNneNknkiisne-----------------------------------------edpnninNII 259 Plasmodium falc...
Q7RGS7       223 LVC--KASDDQTLMEILDneEkkake-----------------------------------------------nnstGLI 253 Plasmodium yoel...
Q4MYQ4       224 YWT--STHDDDCIADVLLetYktspskpleseyqngvegedefdsgdkkqagnmplqgdsasydqamkverdllrydKIV 301 Theileria parva
EDO07617     223 YWT--STNDDDCIMDYLLstQrqesa-----------------------------------------------dagdHII 253 Babesia bovis
EFC42669     231 ILQppASSEDPLLNNKTAp----------------------------------------------------------EAN 252 Naegleria gruberi
XP_007412937 291 VFTTDSVLSLLMCATRSVYPWDIVMIKEGDKLFMDK----R--EGGPF----DFL-SVNENAADPPles-dkPDSLNTPS 358 Melampsora lari...
XP_001018258 257 VYTTDALLLALMTCKKNEFPWDILVQKDGNAIVFDTyeeeRmn-------ymDFQ-SVNENSNILPe----eEKDLN--- 321 Tetrahymena the...
XP_004030408 221 VYTTDALLLALMTLKKGEFPWDIYVQKDGNQIILDKyeadKyeGNNKLfdymEYQ-TVNENGNILPe----eERELN--- 292 Ichthyophthiriu...
Q5CPM5       238 VAITDQILACLVAAAQSKYSWHILVTNVDGKLIFDK----Q--DGSII----DLI-TVNETSAEPPlp--dnVNKNNRPH 304 Cryptosporidium...
XP_001614386 261 VVSTDQILSCLMSAAQSKYSWHLLITKEGNKIIIDK----D--EDSIV----DLL-TVNENSIDAPtq--dnENKINSLQ 327 malaria parasit...
Q8IJW4       260 VISTDQILSCLMSCVQSKYSWHLLIKKKGNQIIIDK----D--DDSII----DLL-TVNENSIDAPtq--dnENKINSLQ 326 Plasmodium falc...
Q7RGS7       254 IVSTDQILSCLMSCVHSKYSWHLIIKKKGNRIIIDK----D--DDSII----DLL-TVNENSLDAPtq--dsENKINSLQ 320 Plasmodium yoel...
Q4MYQ4       302 LAATDQILSVLMTAGRSKHSWHLNVTKIENQIIIDK----A--NGSII----DML-TVNETAPDPPqp--dcEIKINRPS 368 Theileria parva
EDO07617     254 LGATDQILAVLMTAARSKYSWHLNVTKIDNKIIIDK----A--NGSII----DML-TVNETSPEPPlp--daEIKINRPP 320 Babesia bovis
EFC42669     253 VFATDDAIATLMAASKSELPWDMAVRVSEGKIYLDM----RklEGRNI----NLWhSVSETSSNPPsvdeknVQSINSAF 324 Naegleria gruberi
XP_007412937 359 ALSLEATFINQNFGLQVVKED-PETV-YQFENPN-PFygsD-ETe-pCASAGLRYRKFDLSLn------Eee--dLSIII 425 Melampsora lari...
XP_001018258 322 KLCVEATTITKKFQAQTCKEDnGEIWdISEGEPN------QiDE----QNIAFKYVNVNIDDk------------VNLKV 379 Tetrahymena the...
XP_004030408 293 KLCIEATTVTRQFQYQTTQGE-TELWeISEGKEN------QvENm-eNENVAFKYINCNIDDk------------IDIKV 352 Ichthyophthiriu...
Q5CPM5       305 LLGLEALKSNQNYTQNIQIFGdEGII-KQFEPI--PFs--EeNQdtnIESKCYRYRIFSLPPragasssEnaqktVRVAI 379 Cryptosporidium...
XP_001614386 328 ALGFEAIKINQRFRKQVLLKNeQA---EQFDNA--SFt--AkNCk--NFDVLYRYRKILVPPivn--gsSkk--kCTLIT 394 malaria parasit...
Q8IJW4       327 ALGIEAVKINQRFRKQVILKNdIA---EEFEPG--NFn--IkNIk--INDILYRYRKFQIPPlvq--snNkk--tYTLIT 393 Plasmodium falc...
Q7RGS7       321 ALGLEAVKINERFKNHVQLNNqIA---EQYDNT--SFn--SkQCn-nNSNILYRYRKINLPPlih--gsSkt--nCTIIT 388 Plasmodium yoel...
Q4MYQ4       369 SLRYEAVKVNQNLRQQVLLQDeYS---ETFLDP--PFv--EeSDn--PATIAYRYRKFTLPGtpnatnfEkl--pILVIT 437 Theileria parva
EDO07617     321 ALGYEAVKVNQCLRQQVLVSGqFS---DEFELP--PFv--EeGDn--PSTMAYRYRTFMVPGdnhghgwSrv--pIHVIT 389 Babesia bovis
EFC42669     325 SLSKEATLVNAYLQKQAFKEDeV----KKLGNEAvPFst-------gVFNLAYKYREFKLSDs------------INLLV 381 Naegleria gruberi
XP_007412937 426 RAEVDAVLRGSNASvnpnaakeqgtqeEDNF--ITIRTLNEFDSNSQGSggAp-NWRTKLDSQRGAVVATEMKNNSCKLA 502 Melampsora lari...
XP_001018258 380 RVQIDGYDIVNKVDpet-------aepYQEKvpILVRALNEFDSAA--------QWKTKLLNQKGSVTSTEYINNITLFM 444 Tetrahymena the...
XP_004030408 353 RVQIDAFDYVKEYDpenn------dvvSEQKvpILIRTINEYDHSN--------QWKNKLLTQKGTVTGGEYINNCCNYI 418 Ichthyophthiriu...
Q5CPM5       380 RTEIDAQIPNAES---------------ENSgfIFARALNEYDPKTVK------TWNTQLETQKGALLATEIRNNACQLT 438 Cryptosporidium...
XP_001614386 395 RGEIHSKLKGTANs------------------yVYICALNEYDIKSHK------NWRSQIENQKGALLANEIRNNTSKLQ 450 malaria parasit...
Q8IJW4       394 RGEIHSQIKGLNKs------------------yVYVCALNEYDIKSHK------NWRSQIENQKGALLANEIRNNTSKLQ 449 Plasmodium falc...
Q7RGS7       389 RGEIHSKIKGSNNa------------------yVYICSLNEYDIKSHK------NWRSQIENQKGALLANEIRNNTYKLH 444 Plasmodium yoel...
Q4MYQ4       438 RCEVHAKLQGTDTy-------------------TYVCALNECPNKNNK------SWRSQIETQKGALLANEIRNNTTKLQ 492 Theileria parva
EDO07617     390 RGEVHARIPGVSN-----------------GgyTYVCALNELPHKTQK------SWRIQIETQKGALLANEMRNNTAKMQ 446 Babesia bovis
EFC42669     382 RCEINGLSKETSG-----------------DeeMSLKVLNEYFPAEQNQyhNvaDWKTSMESQKTSIIMAEFKNNSAKMA 444 Naegleria gruberi
XP_007412937 503 KWAVQSILAGADQMKMGYISRANPRDASRHVILGQQWFKPKDFASQINVNLANGWGIVRTFVDLALKSPD--GK----YL 576 Melampsora lari...
XP_001018258 445 KWLIQMKLSGAERLKLAYTSRASPKDTQNHNILCVDSFDLQTLTNIIQFKFKDQWQVVKYFIDQILNEKD--GK----YM 518 Tetrahymena the...
XP_004030408 419 KWLIQMEMTGAKMLKLGFTSRVSSKDNTTHDILCVDSFTFEDLFKNIQFRSLDQWQVVKYFIDFICKQPD--GN----YM 492 Ichthyophthiriu...
Q5CPM5       439 KWATQALLSSCDILKLGYIVRRTPNDRESHQIISVQSYKTKELSAQMGLKEENAWGIVRALVDLLSEQPE--GQ----YV 512 Cryptosporidium...
XP_001614386 451 KFICQALISGCEDIKLGFISRKNANDAENHHILSIQSHKTKDLSTQIGLKYENIWGILRYIVDIISEKPD--GK----YV 524 malaria parasit...
Q8IJW4       450 KFISQALLSGCDDVKLGFISRKNANDPDNHHILSIQSHKTKDLSTQIGLKYDNMWGIFRFVIDNLADKPN--GN----YV 523 Plasmodium falc...
Q7RGS7       445 KFICQALLSGCDDIKLGFISRKNANDYENHNILSIQSHKTKDLSTQIGLKYENIWGILKFIVDNISDRSD--GK----YV 518 Plasmodium yoel...
Q4MYQ4       493 RFVACANMAGCGVFKLAYVTRRSPNDAENHSIIGIHTHTTQNLALQMGFSLDNAWGSIKAIVHLVMRRPD--GQ----YV 566 Theileria parva
EDO07617     447 RFAACAIISGCDTLKLAYVSRRSPGDAEHHSIIGIHTYTTENLAVQMGLNMRNAWAVVRHICALIMDRPD--GQ----YI 520 Babesia bovis
EFC42669     445 KWTAQALLSSSKQFKLGFVSRQSPKATKTHLILGTEKYRPEDFADQLQLHLYNMWGVVKLIIEYVQRYLQenNKqdceFV 524 Naegleria gruberi
XP_007412937 577 LMKDPNKPVVRFYK 590 Melampsora larici-populina 98AG31
XP_001018258 519 FVKTAFKQSVKTYl 532 Tetrahymena thermophila SB210
XP_004030408 493 FVKGAFKQSIRTYE 506 Ichthyophthirius multifiliis
Q5CPM5       513 ILRTPVKHVLRVYR 526 Cryptosporidium parvum
XP_001614386 525 ILKDPLKALLRLYC 538 malaria parasite P. vivax
Q8IJW4       524 ILKDPLKPLLRLYC 537 Plasmodium falciparum 3D7
Q7RGS7       519 ILKDPLKSLLRLYC 532 Plasmodium yoelii yoelii
Q4MYQ4       567 LLKDPMKPIIRLYS 580 Theileria parva
EDO07617     521 LVKDPLKANIRFYA 534 Babesia bovis
EFC42669     525 LLKHPNRDRLDLYE 538 Naegleria gruberi
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