Conserved Protein Domain Family
VKG_Carbox

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pfam05090: VKG_Carbox 
Vitamin K-dependent gamma-carboxylase
Using reduced vitamin K, oxygen, and carbon dioxide, gamma-glutamyl carboxylase post-translationally modifies certain glutamates by adding carbon dioxide to the gamma position of those amino acids. In vertebrates, the modification of glutamate residues of target proteins is facilitated by an interaction between a propeptide present on target proteins and the gamma-glutamyl carboxylase.
Statistics
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PSSM-Id: 398660
Aligned: 54 rows
Threshold Bit Score: 456.26
Threshold Setting Gi: 260818826
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFN75118      96 VARALFGLCMVIDVVEERGFANIDIKWGDPWE-CHFPLIHGMRPPsLPWMIMLYTVMWIGAFGIALGLRFKLACACFALP 174 Jerdon's jumpin...
XP_001947732  43 ALRIAFGLLMMIDTMDERGFCQAEKRWMEPMK-CYFPLFDFVKPLpGRWMCLAYAAMFSGVLGVMTGFHYRISCAVYAIP 121 pea aphid
XP_001631057  33 ILRILFGLFMVIDIPQERGLSSLHSRWEEGM--CYFPLFNVLQPLsVDWMHIVYLVMLAGASGIFLGFMFRISCILFIIP 110 starlet sea ane...
EDV21673      45 ITRVLFGFLMIFDITQERGMVYINLRWGDPKA-CEFPLLSNLPILsADWMHILYLSMIAAAIGICIGFYYRIASIWLALG 123 Trichoplax adha...
EDV25694      35 ITRIFYGLLMMFDITLERGMAIINVKWGNPDS-CIFPLFDFIKPLsSDWMHMLYLSMIIASFCICIGLKYHFMTTWLAIC 113 Trichoplax adha...
XP_002115822  49 ITRILYGFLMIVDTTQERGMEKIPYKYKDPEA-CFFPLFNILTPLsADWMHVVYLSMIIAAFCICIGFCYRFVTIWLAVC 127 Trichoplax adha...
XP_003228285  24 dpvpltGLLMALDIPQERGLSYLDHKYLDGLSvCRFPLFNFLEPLpLDWMYLVYTVMLLGALGIMLGCFYRGSCLLFLLP 103 green anole
EDL91038      66 VFRFLFAFLMLLDIPQERGLSSLDRKYLDGLDvCRFPLLDALRPLpLDWMYLVYTIMFLGALGMMLGLWYRLSCVLFLLP 145 Norway rat
XP_016159023 123 AFRAAFGLLMALDVPQERGLGHLDQRYLDGLEvCRFPLLPFLQPLpLDWMYLLYTIMFLgALGIMLGCCYRLSCVAFLCP 202 collared flycat...
XP_006625583  84 VFRFLFGLLMVVDIPQERGLSHLDFKYLDGAPvCRFPLFNFLKPLpLDWMYLLYVIMLFGALGIMLGCFYRLSCLMFIST 163 spotted gar
EFN75118     175 YWYIFLLDKSYWNNHTYLYGIVAILFWGTGADKYFALDASKARr----RDGSVPYWNYFILKFQFFVLYFLAGLKKSSRE 250 Jerdon's jumpin...
XP_001947732 122 YWYIFLADKSSWNNHSYLFGLLIAIFSVTDAHRNWSVDRWLRRkmpldAPSLVPRWNYLLLRIQFFIMYFVAGLKKFEPD 201 pea aphid
XP_001631057 111 YWYVFWLDKGVWNNHSYLYGLFSIMLLMTDSNRYWSLDGLINPk---iRNAEIPKWNYFLFRFQVFLVYFYAGIKKLDQD 187 starlet sea ane...
EDV21673     124 HWYLILIDKTAWNNHTYLFGLFTIFFSVTNANRWWSVDGVLNQk---iNNVHIPRWNLALFQFQIFLVYFLAGVKKLNSD 200 Trichoplax adha...
EDV25694     114 YWYIILLDKTAWNNHTYLLGLFALFFSVTDANRWWSVDGLLDRs---kCNTAIPLWQLLLFRFQIFMVYFYAGIKKFHPD 190 Trichoplax adha...
XP_002115822 128 YWYVFLLDKTTWNNHSYLFGLFALFFSFTKANRWCSVDGKLDQs---iRNTHIPRWHLALFQFQIFLVYFYAGIKKLDPD 204 Trichoplax adha...
XP_003228285 104 YWYVFLLDKTTWNNHSYLYGLLGFQFLFINANRYWSIDGLRNPr---kRNVHVPLWNYTLLRTQVFIVYFIAGIKKLDAD 180 green anole
EDL91038     146 YWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLSAq---kKNAHVPLWNYTVLRGQIFIVYFIAGVKKLDAD 222 Norway rat
XP_016159023 203 YWYLFLLDKTSWNNHSYLYGLLGFQLALLGADRYGSVDGLFRPr---kRNAHVPLWNYALLRAQVFIVYFIAGLKKLDAD 279 collared flycat...
XP_006625583 164 YWYIFFLDKTTWNNHSYLYGLIGFQLTLMDANRYWSIDGLRNPk---kRNADVPLWNYTVLRAQIFIVYFIAGIKKLDSD 240 spotted gar
EFN75118     251 WLEGYAMTNLsrhWVFYPFHFFLTTEQTDFLIVHWFAFVFDLSVGFWMLLEKTRIPAMVLCTAFHLMNTRLFSIGMFPWV 330 Jerdon's jumpin...
XP_001947732 202 WLWGYSMMSLghhHVFTPFRYFFSAEFIDHWIVHVGGFLIDLFSGFGLCFRSTRPFTIIVLLAFHGMNATMFTIGMFPYV 281 pea aphid
XP_001631057 188 WMTGYSMTGLskeWVFDPFRAFLSDETIDLVLVHICGLCFDLFVGFFLLFDKTRPIGILFALAFNGMNSQMFHIGMFSYT 267 starlet sea ane...
EDV21673     201 WITGSSVTTVgshWVFAPLRLLLTTQQISQYVLHYGGLIFDLIEGYLLFFNITRPLGIALGIYFHICNSQIFTIGIFPYA 280 Trichoplax adha...
EDV25694     191 WISGHSMRSLathWIFSPFRTLLTIEQINLHIVHHCGLAFDLFEGFLLYFNTTRPVGLILGCYFHFTNAWIFQIGIFPYI 270 Trichoplax adha...
XP_002115822 205 WITGNSMVSLeahWVFSLFHYVLTPEQVNLYIVHYGGFAFDLMEGFLLFFDITRPIGLLLGFYFHFSNACMFTIGIFPYA 284 Trichoplax adha...
XP_003228285 181 WVEGYSMGSLarhWLFSPFRLVLSEEMTSLLVVHGGGLALDLTAGFLLFLDATRPFALFFVSYFHCMNSQLFSIGMFSYT 260 green anole
EDL91038     223 WVEGYSMEHLsrhWLFSPFKLVLSEELTSLLVVHWCGLLLDLSAGFLLFFDASRPIGLVFVSYFHCMNSQLFSIGMFPYV 302 Norway rat
XP_016159023 280 WVGGFSMGTLarhWLFAPSRLVLSEELPSRLVVHGGGLVLDLSAGFLLFFDATRPLALVFVTYFHCMNSQLFSIGMFSYT 359 collared flycat...
XP_006625583 241 WVGGYSMGYLshhWLFDPFKLVLSEEMTSLIVVHGGGLVLDLSAGYLLFFDATRPIAMFFVTYFHSMNSQLFSIGMFPYA 320 spotted gar
EFN75118     331 CLATMPLFCHVD-------------W-----PRKLGLCFDWRRKVSAADGSSIDdrskvssrsdrsgssssevlddrath 392 Jerdon's jumpin...
XP_001947732 282 CAAMIPVFCDPAtmskmlrtivesvWndksaPKSVVYKPPTRT------------------------------------- 324 pea aphid
XP_001631057 268 MMATLPLFCSPS-------------W-----PKKLFSRMPSWLTFILPTTDAAQqshhcly------------------- 310 starlet sea ane...
EDV21673     281 MLATLHIFCNPD-------------W-----PKKVIMRLSPRWRKYFLLDTPPKysasncyy------------------ 324 Trichoplax adha...
EDV25694     271 MLATLPIFCNPD-------------W-----PKHFVRKLRGHRQNYLVLNRYLFlsyrfnnslnlgdttind-------- 324 Trichoplax adha...
XP_002115822 285 MLATLPIFCRPD-------------W-----PKRLLVKTPQRWQRHFIIDAPKNysssdc-------------------- 326 Trichoplax adha...
XP_003228285 261 MLATSPLFCRPD-------------W-----PRRLVACLPSSLHGLLPLSRPPQpspec--------------------- 301 green anole
EDL91038     303 MLASSPLFCSAE-------------W-----PRKLVARCPKRLQELLPAKAAPRpsa----------------------- 341 Norway rat
XP_016159023 360 MLATNGLFCRPE-------------W-----PRGLLARCPLWLQGWLPSTKPPQpspdc--------------------- 400 collared flycat...
XP_006625583 321 MMATSPLFCYAD-------------W-----PRRFFARFPSCLRVLLPPITPPPqpstscvy------------------ 364 spotted gar
EFN75118     393 egkkeidrdyfaepeaeeeidggddntrlptdstepseeeeedvnvrenipgaRRTTK-------VTRKQKFVVSMLLCH 465 Jerdon's jumpin...
XP_001947732 325 --------------------------------------------------------------------KQNAIVAGVCVY 336 pea aphid
XP_001631057 311 -----------------------------------------------eaakdkQVNSKq------ASLQQLLMLTVFACY 337 starlet sea ane...
EDV21673     325 ---------------------------------------------ndynpddtGSRIQq------FNSQNRLTMAILAGY 353 Trichoplax adha...
EDV25694     325 -----------------------------------glenqliknydftmpycsSRRKSs------LSKRNYITFLFFSLY 363 Trichoplax adha...
XP_002115822 327 -----------------------------------------------iavnsaKLGIRr------FTKKNKFTLFALSCY 353 Trichoplax adha...
XP_003228285 302 ------------------------------------------------iytkgKGPRRr------PGLRQKLGAAFTLLY 327 green anole
EDL91038     342 ---------------------------------------------------scVYKRArakagqkPGLRHHLGAVFTLLY 370 Norway rat
XP_016159023 401 -------------------------------------------------hyggRGARGg------LRPRQHLAAAFTILY 425 collared flycat...
XP_006625583 365 ----------------------------------------------pksssdsASAPAk------PSRRHTLGTLFTLLY 392 spotted gar
EFN75118     466 IALQFFLPYSHFISKGYNNWV-PGlYGYSWDMMVHAwDTVLVVIKVHDNVNNKVRYLDPEAWV-----QSDRWVRHADMA 539 Jerdon's jumpin...
XP_001947732 337 TALQLFLPYSHIVTQGYNGWR-NGlYGYSWDMMVYNvDVAKVQIKVLDHVRREQFYLDPSGWT-----DNNKWMLHGDML 410 pea aphid
XP_001631057 338 VAAQLFLPYSHFITKGYNGWT-QGlYGYSWDMMVHSwSTQHVRIKVVDQVTGKEIFIKPGAFIgggrrRHSRWNSHPDMI 416 starlet sea ane...
EDV21673     354 VTLQLFLPFSHFITQGYNTWNeRGlYGYSWDMMVNSwSYPKIKILVVDLSNGKH-------FIggadsRFLRWSTYPSMI 426 Trichoplax adha...
EDV25694     364 AVLQLCLPFSHQITKGYIAWDgHGlYGYSWDMMIRTwITPYTKITVVDNATQQYYDLKPNTFIhniptINFRWDSHPDMM 443 Trichoplax adha...
XP_002115822 354 IAIQLFLPFSHNVTKGYTGWDdHGlYGYSWDMMVHTwATQHVKITVVDLSNGRQFHLKPSVCYk----YADRWNSHPDMI 429 Trichoplax adha...
XP_003228285 328 ILEQLFLPYSHFITQGYNNWT-NGlYGYSWDMMVHSrSHQHVKITYRDGRTGELGYLNPGVFT-----QSRRWKDHADML 401 green anole
EDL91038     371 LLEQLFLPYSHFLTQGYNNWT-NGlYGYSWDMMVHSrSHQHVKITYRDGLTGELGYLNPGVFT-----QSRRWKDHADML 444 Norway rat
XP_016159023 426 VLEQLFLPYSHFITQGYNNWT-NGlYGYSWDMMVHSrFHQHVKITYRDGLTGEVGYLKPGAFT-----QSRRWRDHADML 499 collared flycat...
XP_006625583 393 ITEQLFMPYSHFITQGYNNLT-NGlYGYSWDMMVHSrSHQHVKITYRDGKTGEIGYLNPGVFT-----QSRRWKDHGDML 466 spotted gar
EFN75118     540 LQYSQCMKDNLMRR-KEkalsdsrqaeekqmwmklsANLSIYIDVWCSLNGRFQQRVFDPHVDMLTVDwHPFKPVSYLMP 618 Jerdon's jumpin...
XP_001947732 411 KQFAGCVAANMPDR-H--------------------DNMSITMDIWGSLNGRFHQRLVDPNVDLLHAPwSPWSSVPWLLP 469 pea aphid
XP_001631057 417 KQYVDCLAEKLKAR-EDld----------------iSEPAIYLDIWRSMNRRFQQRFVNPNIDILHADwSPFQKTTWVQP 479 starlet sea ane...
EDV21673     427 KQYGNCLAKQMKTSyEI-------------------KQPAVYLDIWKSMNGRFRQRLINPKVDIVSAPwSPWKKTPWLMP 487 Trichoplax adha...
EDV25694     444 KQYAMCIARHAKKF-GV-------------------KKPAVYFDIWKSLNYRFQQRLVNSNIDLVSAEwSPWKATSWIMP 503 Trichoplax adha...
XP_002115822 430 KQYATCIGRRVKKL-GV-------------------KQPAVYFDIWKSMNRRFKQRTVDPSVDVLAAPwSPFTKTPWMMP 489 Trichoplax adha...
XP_003228285 402 KQYATCLSGLLQNY-NI-------------------SEPEIYFDIWVSINDRFQQRLFDPGTDIVRAEwSPFWKTPWLKP 461 green anole
EDL91038     445 KQYATCLSLLLPKY-NV-------------------TEPQIYFDIWVSINDRFQQRLFDPRVDIVQAVwSPFRRTPWVQP 504 Norway rat
XP_016159023 500 KQYSACLSRLLPRY-NV-------------------SQPQIYFDVWVSINERFQQRLVDPRVDLVRAPwSPWTPTPWLLP 559 collared flycat...
XP_006625583 467 KQYATCLSQQLLNY-NI-------------------SEPEIYFDIWVSINERFQQRIFDPRVDIVKADwSPFRPTPWLMP 526 spotted gar
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