Conserved Protein Domain Family
Spo12

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pfam05032: Spo12 
Spo12 family
This family of proteins includes Spo12 from S. cerevisiae. The Spo12 protein plays a regulatory role in two of the most fundamental processes of biology, mitosis and meiosis, and yet its biochemical function remains elusive. Spo12 is a nuclear protein. Spo12 is a component of the FEAR (Cdc fourteen early anaphase release) regulatory network, that promotes Cdc14 release from the nucleolus during early anaphase. The FEAR network is comprised of the polo kinase Cdc5, the separase Esp1, the kinetochore-associated protein Slk19, and Spo12.
Statistics
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PSSM-Id: 398624
Aligned: 30 rows
Threshold Bit Score: 36.928
Threshold Setting Gi: 134747
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P17123              117 ASPTDRLVSPCSLKLNEHKVKMFgkKKkVNPMKLN 151 Saccharomyces cerevisiae S288C
XP_009157229         71 iSPSDAMQSPTTKKLSEIKGRRF--MN-AKPQ-TL 101 Exophiala dermatitidis NIH/UT8656
GAA89841             56 VSPSDDIMSPCSKKLSDLKGKRF--KNaGKPQ-SL 87  Aspergillus kawachii IFO 4308
XP_002544827         64 VSPSDNIMSPCTKRLTDMKVKML--KN-MKPQ-AL 94  Uncinocarpus reesii 1704
KJF60500             72 VSPSDDIMSPCTKKICDLKGKKF--KN-AKPQ-VL 102 Coccidioides immitis RS
ESK97610             63 iSPTDNLMTPCTQKLSAAKKKHF--TKtSKPV-QL 94  Moniliophthora roreri MCA 2997
EFJ01812             61 VSPTDNMMTPCTQKLNAAKKKQF--SK-AKPT-QL 91  Schizophyllum commune H4-8
XP_007329499         66 VSPTDNLMTPVSQKLNAAKKKQF--SKgAKPV-QL 97  Agaricus bisporus var. burnettii JB137-S8
XP_002473358         65 iSPTDKMMTPVSQKLNAAKKKHF--TKgAKPMPSL 97  Postia placenta Mad-698-R
WGS:AATM:SJAG_01341  47 ASPTDNLMSPCTAKLQAHKKKYY--TK-GKPV-SS 77  Schizosaccharomyces japonicus yFS275
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