Conserved Protein Domain Family
TIMELESS_C

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pfam05029: TIMELESS_C 
Timeless protein C terminal region
The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologs of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2). mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function. Some family members contain a SANT domain in this region.
Statistics
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PSSM-Id: 398621
Aligned: 43 rows
Threshold Bit Score: 79.2725
Threshold Setting Gi: 1367099549
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CRK93394       912 LRDRLLK-ENKG--NLILWLQRVLTECCyvklnllysnenisntstfstiMEpipRHCIlnkQSIPLVPFNSEQNKILVY 988  Clunio marinus
XP_016662949   983 AIKKVID-KDMK--TALLWLVESLDEAAn--------------------dLD---VDES----DIPLLPLTDECMTAVND 1032 pea aphid
CDW58277      1033 LVGSLMK-SGFG--EAIDWLIQVITETIed-------------------nAA---QKTSeigEAIPVVPIEEIHCKAVRR 1087 human whipworm
15_pfamImport    1 SASILRPkRGFIi-EPVAYH--CISKNK-----------------------------------SIPIVPWNSDHSAMMQY 42  
XP_002432421   864 LNCDVNY-DPIT--KPLEPIPHYYSHLN----------------------------------QSIPIVSWNAEQADVLLL 906  human body l...
CDY50493      1004 VSRKLKQ-LGLR--LPRGKKSEAGMKLQd-------------------------dHDDSsadESDNETLLAFKKRKSMTR 1055 rape
CAP91753       881 EGEDIPD--GPLfpANPRSKSSALDDLK-----------------------K---KRKKk-qATTEREPLDDETLEARRD 931  Penicillium ...
XP_027230630  1193 LIGQLKE-EGYG--AQVQWLQLQLLEACysklkmv---------gpnlpkAEpvpCHFTlsnQSIPLVPWTSEQEEAFSS 1260 Pacific whit...
RWS04784       934 LVTELIE-LGFR--QQLNWIKDLLLETCfvkilndk-------elnnysiPEpvvYYNNyigQSIPIVPYNEKQEKALYN 1003 Dinothrombiu...
RZF48533        84 ALNNAVF-DGFK--EPLEWLVSSMTEMLe--------------------dLE---DNQE----DVPLLPLTETCTQAMEN 133  small brown ...
CRK93394       989 QPFVLLLHKL-GFHL---------PADAN--KLFVRIPEFWTSEILL 1023 Clunio marinus
XP_016662949  1033 IDFQEMMQVL-GIHK---------PSSIQ--ETYWRIPGRWQANDIR 1067 pea aphid
CDW58277      1088 PDFKRLLHEL-NFWA---------PDGIQ--HKYWRIPDTFSVLQLQ 1122 human whipworm
15_pfamImport   43 HPFVLLLHKL-GFHL---------PADSG--SVYPRVPEFWTADLMY 77  
XP_002432421   907 QPFQLLLHKL-GFHL---------PADTG--KVFARIPSFWTVDVLF 941  human body louse
CDY50493      1056 RKLEKHTRPSnEISP---------EGSEDktERNETSPDVIATSKEE 1093 rape
CAP91753       932 ARLSNALSRQaKIKSdlfihasdeESDEEadKEFFRLEEERRIQQAK 978  Penicillium rubens Wisconsin 54-1255
XP_027230630  1261 LKFRQLLGEL-GFHL---------PSDTG--KIFPRIPHFWCPEVLF 1295 Pacific white shrimp
RWS04784      1004 NKFLQLLHKL-GFHL---------PTDVG--RIYPRIPSFFTPDLLF 1038 Dinothrombium tinctorium
RZF48533       134 GSFTSMIEVL-GVKK---------P-DEQ--EIFWRLPGNWSEAKIK 167  small brown planthopper
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