Conserved Protein Domain Family
Coq4

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pfam05019: Coq4 
Coenzyme Q (ubiquinone) biosynthesis protein Coq4
Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).
Statistics
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PSSM-Id: 398612
Aligned: 107 rows
Threshold Bit Score: 219.66
Threshold Setting Gi: 428248936
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4DBV7                         15 AASSLPAFVAATTRSIWDPVNADDVAAVGEITALTALGHMKQSMMSDRTGRMILRTQPRVTDETL-----------EFAS 83  Trypanosoma cruzi strain CL Brener...
Q382H9                         19 AVKSLPAFVTSSFGAIVDPEDGRGSAAFAEITALTALHHMQRLMMADEMGRSILKERPQVTDETL-----------EFAK 87  Trypanosoma brucei brucei TREU927...
WGS:AAGF:cds.TTHERM_00275760A  56 NAERLLLVAKNAINAFIYNAQGQHLSNLGCLTSYSTLQEVRERMMKDEVGRQILLEKPRINHDSA-----------NIEY 124 Tetrahymena thermophila SB210...
A0DUC3                         15 NFERLSTLFQCAINAYKYPLNGNHLSQLGELSGYYCVKDIHQRMLQHPVGQRILIDKPRVTPETF-----------KVEE 83  Paramecium tetraurelia...
EED88476                        4 PLQRLATLLHSSITALNDPTRADAVAAVGEVTGSYALSRMMQTMQNDEIGRRILKERPLVNETVAerafrlleqhnNMNE 83  Thalassiosira pseudonana CCMP1335...
EFC43656                       30 FLEKTFITAGSTLISAFYPLRTDMVGALGETTGTPALEYVRSQMVLTKEGNEILKERPNIDERVNp----------KFWE 99  Naegleria gruberi...
EGG20836                       65 LFQKVLLGVGSSLIAMYNPGRTDMVAALGEVSGGCVLPHLKTKMMNDSDGRWLLEHKPRIRIETL-------------PE 131 Cavenderia fasciculata...
EFA86737                       72 LFQKVLLGVGSSIVAMINPGRGDMIATLGEITGGCALKTLKKKMMEDEVGRDLLARKPRIRSETF-------------PP 138 Heterostelium album PN500...
XP_003285140                   58 LFQKGLLTVGSAFVAFANPERGDMVATLGEVTGGCAIKAMKEKMMKDPVGRELLRDKPRIKESTY-------------PQ 124 Dictyostelium purpureum...
Q54CZ2                         60 LFQKGLLTIGSAFVAFINPGRGDMVATLGEMTGGCAIKSMKQKMMLDPIGRQLLKEKPRIKESTY-------------PL 126 Dictyostelium discoideum...
Q4DBV7                         84 ---RQPPG---TFG--------HRYAQFMKFNRFTPNGRTPVAHIADPTLAYVMQRQRETHDFLHTCIGCGRTVEEEIIV 149 Trypanosoma cruzi strain CL Brener...
Q382H9                         88 ---TQPEG---TFG--------YRYAAFMKRNNFLPSGRAPILHVSDPTLAYVMLRYRQIHDFVHAYVGLGRTIEEELAV 153 Trypanosoma brucei brucei TREU927...
WGS:AAGF:cds.TTHERM_00275760A 125 l-lSLPKN---TFG--------YHYGRFMGDRDFSSEERPKVTYMPDFELAYIYQRYKEIHDFIHTLLGFDVTVYDEIVV 192 Tetrahymena thermophila SB210...
A0DUC3                         84 l-lKLNQN---TFGqhssliqsYQYGKFMRDRDFSSSERPIVKYIPDLELAYVYQRYKEIHDFIHVLLMYDVSVYDEIVV 159 Paramecium tetraurelia...
EED88476                       84 l-kSTANNnsmTFG--------AAYATFLQTHNFDPNERSPIRFITDPNLSYVMTRYRQCHDYWHALTELPPTVLGELAL 154 Thalassiosira pseudonana CCMP1335...
EFC43656                      100 yisTLPPD---TFG--------GAYYKFMSTNGFVASERPPVRFIDDEELAFIMFRYRQCHDYFHVLADLPPSVYAEIIV 168 Naegleria gruberi...
EGG20836                      132 qlsSLAPD---TFG--------GAYYKFLTDNGFSPDDRAEVRMVEDDDEAYVLQRYREVHDFWHVLADIPPNVPGELAI 200 Cavenderia fasciculata...
EFA86737                      139 nlhLLPPT---TFG--------GAYYHFMNIHGYSADERTHVRMIEDDDEAYIMQRYREVHDFWHVLAGVDTTVQGELAV 207 Heterostelium album PN500...
XP_003285140                  125 nihLLPTT---TFG--------GSYYQWMKAHGYTPDERCEVRMVENDDDAYVIQRYREVHDFWHVLAGIRPDVQGEIAI 193 Dictyostelium purpureum...
Q54CZ2                        127 nihLLPST---TFG--------GAYYRWMKEHGYSPDERTEVTLIQDEDDAYVMQRYREVHDFWHVLAGVRPDFQGEVAI 195 Dictyostelium discoideum...
Q4DBV7                        150 KLLEWRHTGLPIGLLA----VIGSLpWLSRQQIRN-MELYFEWAEVNAPNQRhgEVnipyiTNVWWEY-YLDKPYEQLLA 223 Trypanosoma cruzi strain CL Brener...
Q382H9                        154 KLFEWQHTGLPVGLMA----VLGGMpWLRMDQILN-MGMYNEWARANAPRQLhgKRfvsciLNVPWEW-YLDKPYEQLVD 227 Trypanosoma brucei brucei TREU927...
WGS:AAGF:cds.TTHERM_00275760A 193 KWYEMVQLGFPSTGLSs---FVGPL-KFSQEEITRfNTEDLPMIIQQAKQSQ--FI-----MNIYFEK-EFETNIHDLRK 260 Tetrahymena thermophila SB210...
A0DUC3                        160 KWYEMAQLGLPSATLSa---FVGSF-KLNCQEKQKlLET-LPEILKRANRSE--FI-----MNVYFEE-HINTDLTQLRK 226 Paramecium tetraurelia...
EED88476                      155 KWVELMQTGLPLAALSatggAFGAS-GLSEEEREIlWSVYFPWAIRVGQNMKgnAL-----MCVYYEE-EFETDLGVLRD 227 Thalassiosira pseudonana CCMP1335...
EFC43656                      169 KWIEFFQTRLPMTLLSg---AAAPLtQLTFEQQKElATVFLPWALDAGRNCK--FL-----MGVYFEKyHLEKPVEQVRK 238 Naegleria gruberi...
EGG20836                      201 KWLEMVQTGQPMCALSa---LVGPL-RLPFQQQRQlIQHTAPWAVRCGRNSK--FL-----LNVIYEN-HWNDNLIELRK 268 Cavenderia fasciculata...
EFA86737                      208 KWLELLQTGLPMCAISa---AVGPL-RLPFAEQKVlVTHMIPWAVRCARNSK--FL-----MNVRYED-HWETPIEDLRK 275 Heterostelium album PN500...
XP_003285140                  194 KWFELIQTGLPMTALSs---LVGPL-RCPSGERAElINHMIPWAIRSSKNCK--FL-----MNVKYED-HWEDDINEFRK 261 Dictyostelium purpureum...
Q54CZ2                        196 KWFEFLQTGLPMNAIGs---IIGPL-RCSWNERNElINHMIPWAIKSSKSCV--YL-----MNVKYED-HWEDDLNEFRA 263 Dictyostelium discoideum...
Q4DBV7                        224 DTGITPI 230 Trypanosoma cruzi strain CL Brener
Q382H9                        228 DVGIVPL 234 Trypanosoma brucei brucei TREU927
WGS:AAGF:cds.TTHERM_00275760A 261 RLGLTLd 267 Tetrahymena thermophila SB210
A0DUC3                        227 SLRll-- 231 Paramecium tetraurelia
EED88476                      228 RIGIEPA 234 Thalassiosira pseudonana CCMP1335
EFC43656                      239 ELNFRia 245 Naegleria gruberi
EGG20836                      269 KLNFEPy 275 Cavenderia fasciculata
EFA86737                      276 LLNFEKy 282 Heterostelium album PN500
XP_003285140                  262 MLNFEPY 268 Dictyostelium purpureum
Q54CZ2                        264 KLNFIPy 270 Dictyostelium discoideum
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