Conserved Protein Domain Family
HupE_UreJ

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pfam04955: HupE_UreJ 
HupE / UreJ protein
This family of proteins are hydrogenase / urease accessory proteins. The alignment contains many conserved histidines that are likely to be involved in nickel binding. The members usually have five membrane-spanning regions.
Statistics
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PSSM-Id: 428218
Aligned: 40 rows
Threshold Bit Score: 92.2836
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q117C3         35 S------TTELAMAHHPMGGkipANfw---eGLISGMGHPIIGIDHLSFVVGVGLIAAGM--SNSILVLVSFLATAMLGT 103 Trichodesmium ...
jgi:Sama_3272   8 Wcl---lFSAGASAHEVAL----GG------GFGAGFSHPVLGLDHLLAMLSVGMVSTRLgrHAIWQVPLAFLCFMSLGA 74 
WP_011761352   16 Tm-----VAWPAAAHDIYA----NG------GFLAGAIHPFLGLDHLLTIFAASLIGMQLggRARVSVPLAFLLFFIFGD 80  Shewanella ama...
O66897          6 Pfv---gLASFAFAHPGHFHgv--------nPFNSGLIHPLTGLDHLSVMVAVGLLGSYYagKKAFLPALTFVSFMTLGS 74  Aquifex aeolicus
P73671         69 L------TFPRLLAHHPFGGhtpSNfl---eGFLSGLGHPVIGLDHLAFVIAIGLIAAGL--RYGWLMPLIFVATAITGT 137 Synechocystis ...
Q31NG6         28 Lll---sIASPAFAHHAMGG---QTptsifeGLLSGLAHPIIGVDHFAFVIAVGLLASVT--RQGFLSIFAFVIAALIGT 99  Synechococcus ...
Q1H0F6         10 Gll---aFSPLAFAHPGHESq----------GLVAGFMHPLTGLDHLLVMLAVGMWAGRIggAARWQLPATFVAVMALGA 76  Methylobacillu...
jgi:Pden_5001   8 Fll---lSPAVALAHPGHLH---GG------GFASGFSHPLLGLDHVVAMVAVGLWAASLggAAAPILLLAFPLAMMAGG 75 
WP_012187192   15 Lvs---lSAMPALAHETHGH---GG------GFVAGFTHPILGWDHVAAMVAVGLWGAFLgaPAIWILPVVFPLVMALGA 82  Dinoroseobacte...
jgi:Xaut_2123  13 AflfaaiPLAPAFAHTGTGV---SL------GLLSGFMHPLSGADHLVAMVAVGLWGAQLgnPAIWVLPVTFPLVMAVGG 83 
Q117C3        104 GIHLLSIDLPLTEIAIAISVVALGAMLAFKQKLNTPLVIIFAAISGIFHGYAYGEAIIGSEMTPLlaYLIGFTAMQLFIA 183 Trichodesmium ...
jgi:Sama_3272  75 VLGITDIALPLVEAGIALSVMLLGLAIAFNRALPLWPAMLAVAVFGIFHGHAHGMEMPTLASPWL--YGLGFILGTATIH 152
WP_011761352   81 IIGLLQVPMPWVEPGIALSGILLGLALLMGRDVPLSFAQALVGIFALFHGHAHGTEIPMGANPVW--YTLGISVGTVAIM 158 Shewanella ama...
O66897         75 ILGLLGVSVPFVESGIILSVALMGILL-FAKDLKLSYVLPLIGIFGILHGVAHGYEAPQTLHPVY--YVLGFVLSTAALH 151 Aquifex aeolicus
P73671        138 GLHLIGANLPQPELVIAGSVLLFGIFLALGRPLPSPLVMGLAAVAGMFHGYAYGEAIVGAQMNPVaaYLLGFSFIQLAIA 217 Synechocystis ...
Q31NG6        100 GLHLANLNLPGAELLISGSILIFGCLLARKKALPVAAIAGLAAIAGLFHGYAYGEAIIGAGMPPLfaYLVGFTLTQLVIA 179 Synechococcus ...
Q1H0F6         77 VIGMAGYRLPAIETLLAASVMALGALLVVSLRLPRTLQAGLVALFALFHGIAHGSELAASQG-LA--VMLGMLAATALLH 153 Methylobacillu...
jgi:Pden_5001  76 LLGAADVPLPAVEAGIAASSIVIGVAVMLALRPPLWAAGLVVAAFAVFHGHAHGTEMPAAGNLAP--YAAGFVLATLLLH 153
WP_012187192   83 VLGIAGVPVPAIETGIALSAVVLGLMIAFVVRPPLWVAAVIVGLFAVFHGYAHGTELPGTVNAFA--YAVGFVISTGLLH 160 Dinoroseobacte...
jgi:Xaut_2123  84 LLGVLGVPLPAVEPVIAVSGIALGLMVALSARPPLWVAAVMVGVFAIFHGYAHGRELPEAADAVA--YAVGFVGATGLLH 161
Q117C3        184 LFAMKSAELVSSYWQNqff--rlMSFLGLFISTIG---L 217 Trichodesmium erythraeum IMS101
jgi:Sama_3272 153 LIGVFTGLLLAMKERRyp----lTRITGAGIAAMGt-lF 186
WP_011761352  159 LFGGAVAWYLSLIDQPkp----lLRGLGGIITSLG---L 190 Shewanella amazonensis
O66897        152 FTGLLFGKALKEKl---------VRVSGLLLLALAf-lL 180 Aquifex aeolicus
P73671        218 MGVYALAKGWYETKETll----nLRFIGFLLTGVG---L 249 Synechocystis sp. PCC 6803
Q31NG6        180 ISAWAVGCTLIRQQSAtesltapLKTSGLVLVGIGlafl 218 Synechococcus elongatus PCC 7942
Q1H0F6        154 VLGLAVSSRRLQLPEMv------HSVFGCTMVVLGa-wL 185 Methylobacillus flagellatus KT
jgi:Pden_5001 154 LAGLGIGRVGRLHPGPm-----lSRGLGAVIALVGsfaL 187
WP_012187192  161 MIGIAFGLAIKWPAGRm-----aVRGAGGLISIAGv-aF 193 Dinoroseobacter shibae
jgi:Xaut_2123 162 LSGILIGVLVGWEAGAr-----vVRACGAAIGCVGv-yF 194
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