3NH8,1YW6,2G9D


Conserved Protein Domain Family
AstE_AspA

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pfam04952: AstE_AspA 
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Succinylglutamate desuccinylase / Aspartoacylase family
This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in human ASPA lead to Canavan disease disease. This family is probably structurally related to pfam00246 (Bateman A pers. obs.).
Statistics
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PSSM-Id: 398556
Aligned: 28 rows
Threshold Bit Score: 202.181
Threshold Setting Gi: 81528591
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3NH8_A  19 PLLRVAVTGGTHGNEMCGVYLARYWLQNPGELQ-RPSFSAMPVLANPAATAACCRYLDRDLNRSCTLTFLGstatpd-dp 96  house mouse
P72208   2 SGIQVLLVAGTHGNEINAPWLFEQWKQKDSLIN-THNINIQTVIGNPVALEQGKRYVDRDLNRSFRKDLLLssdln---a 77  Prochlorococcus marin...
Q8EEN9  52 QGKDVILSCGVHGNETAPIELCNTLIKQLLQQKiIAKQRTLFLIGNPLAINNGTRIIDENMNRLFSGEHSNppglvnper 131 Shewanella oneidensis...
Q9ZC70  42 YTQSVVISAGIHGNETAPIEILNQLVTDLLAGQlPLSVRLLVLLGNPPAIRKGKRYLSNDINRMFGGRYQHytpsd--et 119 Yersinia pestis
1YW6_B  47 PQGALVISAGIHGNETAPVEXLDALLGAISHGEiPLRWRLLVILGNPPALKQGKRYCHSDXNRXFGGRWQLfaesg--et 124 Escherichia coli
Q8ZPU8  42 VDRALILSAGIHGNETAPVEMLDKLLSALYSGSlTLTWRVLVVLGNPQALAAGIRYCHSDMNRMFGGRWQSfaesd--et 119 Salmonella enterica s...
2G9D_A  52 ATKNXVISCGIHGDETAPXELLDKWIDDIVSGFqPVAERCLFIXAHPQATVRHVRFIEQNLNRLFDDKPHTpste----l 127 Vibrio cholerae MO10
Q88EI7  48 CGLDLLLSAGIHGNETAPIELLERLLHGVANGKiRPRARVLFLFGNPAAIRKGERFIEQDINRLFNGRHELssgfe---a 124 Pseudomonas putida KT...
Q885J4  48 NGTDLLLSAGIHGNETAPIELLDELIRSIARGDlKPRARILFLFGNPAAMRLGARYVEQDVNRLFNGRHEQsggae---a 124 Pseudomonas syringae ...
O50177  48 NGVDLLLSAGIHGNETAPIELLERLIRKVAAGTlKPAARVLFLFGNPEAIRRGERYVEQDMNRLFNGRHEEgsgne---a 124 Pseudomonas aeruginos...
3NH8_A  97 yevKRARELNQLLGPKGtgQAFDFTLDLHNTTANTgVCLISESNI-SFNLh---lCHYLQRQ--NPGMPCrlFLYEPAGT 170 house mouse
P72208  78 aehFRALELVSEYGPNGn-NPCQIAIDFHSTTSSMgSSLVVYGRRpAD-------LAIVSLIqnHLGLPIylHEGDNA-- 147 Prochlorococcus marin...
Q8EEN9 132 lraKKLETYVDRFFKAAaaGRQRIHYDLHTAMRASkHEKFAIYPYrPGRAysaeqIMFLAAS--GVDTVLf-HHEPTTTF 208 Shewanella oneidensis...
Q9ZC70 120 rraSTLEQRVMAFFQASh-TSERLHYDLHTAIRGSyHPRFGLLPYqQTPYsa-amFRWLRDI--ELDALVm-HTSAGGTF 194 Yersinia pestis
1YW6_B 125 craRELEQCLEDFY-DQgkESVRWHLDLHTAIRGSlHPQFGVLPQrDIPWde-kfLTWLGAA--GLEALVf-HQEPGGTF 199 Escherichia coli
Q8ZPU8 120 rraRELELSLETFF-SSgqARVRWHLDLHTAIRGShHLRFGVLPQrDRPWet-dfLAWLGAA--GLEALVf-HQAPGGTF 194 Salmonella enterica s...
2G9D_A 128 aiaDNLKVLLRQFF-ANtdEHSRWHLDLHCAIRGSkHYSFAVSPKaRHPVrsrslXQFIEQA--HIEAVXl-SNAPSSTF 203 Vibrio cholerae MO10
Q88EI7 125 lraAELEQFARVFF--SkpGRNRLHYDLHTAIRGSkIEQFALYPYkEGRKhsrreLARLAAA--GMEAVLl-QSKSSITF 199 Pseudomonas putida KT...
Q885J4 125 lraCELERLAASFF--SlpDRYRLHYDLHTAIRGSkIEQFALYPWkEGRQhsrfeLARLRAA--GISAVLl-QNKPSIVF 199 Pseudomonas syringae ...
O50177 125 fraAELERLAQVFF--SktERVHLHYDLHTAIRGSkIEQFALYPWaEGRQhsrseLARLRDA--GIEAVLl-QNKPGITF 199 Pseudomonas aeruginos...
3NH8_A 171 ETFSVESISKNGICLAMGPQpqGVLRADLFSRMRALVASILDFI-ELFNQGmdlp-afemDIYRNLGSVDFPRTADGDLA 248 house mouse
P72208 148 QSGFLVESWPCGFVVEVGPVpqGLLHFQIINQTLLTLDSCLKEIsNVINSKtvyp--eqlIVHRHLKNIDFPRDSSGVPS 225 Prochlorococcus marin...
Q8EEN9 209 SYFSSEQYGADAFTIELGKV--YPMGQNDMTRFIAAQEMFTRLI-TDKPLQlesfstdkvNLYQVCRVINKHFD------ 279 Shewanella oneidensis...
Q9ZC70 195 AHFSSERCQAASCTLELGKA--LPFGENQLSQFSAITQGLRSLV-SDSALParkt--enmKYYRVVKSLLRQHP------ 263 Yersinia pestis
1YW6_B 200 THFSARHFGALACTLELGKA--LPFGQNDLRQFAVTASAIAALL-SGESVGivr---tppLRYRVVSQITRHSP------ 267 Escherichia coli
Q8ZPU8 195 THFSSEHFGALSCTLELGKA--LPFRQNDLTQFNVTSQALSALL-SGVETStsf---sppLRYRVVSQITRHSD------ 262 Salmonella enterica s...
2G9D_A 204 SWYSAEHYAAQALTLELGQV--ARLGENLLDRLLAFDLAXRDLI-SRHKPEhlp---rksVXYRVSRTIVRLHD------ 271 Vibrio cholerae MO10
Q88EI7 200 SAFTYEQLEAEAFTLELGKA--RPFGQNEQVNLDKLEERLIRII-EATEPEdess-ldglQLFSVSREIIKHSD------ 269 Pseudomonas putida KT...
Q885J4 200 SAYTYEQLGAEAFTLELGKA--RPFGQNRHVNLAPLRLRLEQII-EGSEPQpder-leglQLFSVAREVIKRSD------ 269 Pseudomonas syringae ...
O50177 200 SAYTYGQLGAEAFTLELGKA--RPFGENQEVNLERLERSLELLI-DGSEEQpdgsrldglKLFSVSREVIKHSD------ 270 Pseudomonas aeruginos...
3NH8_A 249 GTVHPQL---QDHDFEPLRpgEPIFKLFSGEDvLYEG---DSIVYPVFINEAAYYEKHVAFLKSEKI 309 house mouse
P72208 226 SLVHKDI---QGRDWYPIKngHPLFESLSGDLtLLLEgglEEEFVPVFINEAAYAEKNIAMSLTKKE 289 Prochlorococcus marinus subsp. mar...
Q8EEN9 280 ---DFEFtfaTDVENFRAFpkGFVLARE-GGQeIKVE---QEVESIVFPNAKVPIGNRTVICLIPSV 339 Shewanella oneidensis MR-1
Q9ZC70 264 ---DFKLrvaEDTVNFTRFaqGTLLTEQPNDNyRVEH---PY-EWILFPNPHVALGLRAGMMLVKMC 323 Yersinia pestis
1YW6_B 268 ---SFEXhxaSDTLNFXPFekGTLLAQD-GEErFTVT---HDVEYVLFPNPLVALGLRAGLXLEKIS 327 Escherichia coli
Q8ZPU8 263 ---KFALymdAQTLNFTAFakGTLLAEE-GDKrVTVT---HDVEYVLFPNPSVACGLRAGLMLERLP 322 Salmonella enterica subsp. enteric...
2G9D_A 272 ---DFDFrfsDDVENFTAFxhGEVFGHD-GDKpLXAK---NEGEAIVFPNRKVAIGQRAALXVCKVN 331 Vibrio cholerae MO10
Q88EI7 270 ---SFHLhlpADIENFSELskGYLLAEDLAEMrWVVE---EEGARIIFPNPKVKNGLRAGILIVPDS 330 Pseudomonas putida KT2440
Q885J4 270 ---AFTFnlaDDVENFSELekGYVLAEDVSDSrWVVK---EEGARIIFPNPKVKNGLRAGIVIVPAD 330 Pseudomonas syringae pv. tomato st...
O50177 271 ---HFRLhldDDVANFTELspGYLLAEDIGGTrWVVD---EVGARIIFPNPRVKNGLRAGILVVPAK 331 Pseudomonas aeruginosa PAO1
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