Conserved Protein Domain Family
SIP1

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pfam04938: SIP1 
Survival motor neuron (SMN) interacting protein 1 (SIP1)
Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans.
Statistics
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PSSM-Id: 398549
Aligned: 159 rows
Threshold Bit Score: 42.0512
Threshold Setting Gi: 403216996
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ETW83753      32 PSNFE---GEPEDGMQYLFTVRRETRQLPAVKRApnpy----------etapPEPALPSAS------TFIASTIAPSPPS 92  Heterobasidion ...
EEH55290      61 DPDFDs--GPPMDGLEYLRRVRHEAKQVPDVMVSssmppesrsrsststsasASLDRRRELaaasasRKGSQLSRAQRNA 138 Micromonas pusi...
XP_002504770  56 DPDFDs--GPPVDGFEYLRRVRHEAKNVPDVMVSpt--------------idPRAFDHKQT------RGYVPELGGYVPP 113 Micromonas commoda
PRW56469      68 EPDWE---AECLDVQEYLRRVRYEAEHLPDVVTAapp-------------sqQTAADAPNPqrdrptSFDRFLAADPGVA 131 Chlorella sorok...
GAX75712      38 LPDLSs--GPPDTAEAYLQWVRYEAMNCPQVMRVdi--------------taEKLTRNEES------KSNDNVHGHSQSS 95  Chlamydomonas e...
5_pfamImport   1 EPDWSl--DEPDSAEEYLRRVRYEASRCPRVVRAelp-------------atAAAAGGHVA------ARSGRQVLPDV-A 58 
XP_005706319  32 EGDLGdlsLPPSTPEQYLRRVRQEARSLPDVVYW------------------QEWCKQNVD------STVVASQSPREKT 87  Galdieria sulph...
XP_014154423  25 VDAFDp-tQPPATGEDFLRQVRHEARQYASTMTS-------------------STVNPRLY------DIQQTVAIPQLSD 78  Sphaeroforma ar...
PXF41650      21 SPSSQssdAPPVTAEQYLRRVRRELDALPQTVVAet---------------sPPPPPPPQT------RSSLPISRIPPHP 79  Gracilariopsis ...
XP_003081432  32 EPDYAs--GPPMDGFEYLRRVAYEARQSPDIMRA------------------ENLDASVFS------TQSAGVYAAKVDE 85  Ostreococcus tauri
ETW83753      93 QKSH------IP---SEQ--WRS-TFTRRFVNFRKNT-SQPTIHVYmp--------mPRARGQKLMPDKKER-----DRW 146 Heterobasidion ...
EEH55290     139 ACVP------APphaIMDraWRD-AFLADFSDVRAAMtRAMARLGNdgg-----ggdGARAAAAAATKASDAalageDDD 206 Micromonas pusi...
XP_002504770 114 KCPDc----aRP---DKD--WQR-EFLADFSDLRAWVlRTAARRETsgqsa-gggkgLALASQAALERMDDLnepegVSF 182 Micromonas commoda
PRW56469     132 PCDPs----lKP---SAA--WTL-DFLRQFSQLRRRLqREFELTCGqpa-----agaDLGGGLRISPEAAAGsgaleAAA 196 Chlorella sorok...
GAX75712      96 SLPDcpa-waAP---SVT--WVR-EFLLDFKLFRQQLlRLAEEHQQ-------------ELSHVNVPASRDM-----QHW 150 Chlamydomonas e...
5_pfamImport  59 PIADapd-waKP---NRS--WVL-QFVADFQALRQQL--QEACLAG-------------GYPVVQVPHVNDA-----EAW 111
XP_005706319  88 NCFP------QE---FEF--LNNkDYLAHFKQVRDSIaMIESDSNM-----------------VELPEASDV-----KAW 134 Galdieria sulph...
XP_014154423  79 TSNRgpp-erLP---SED--WER-YVLDEFKLAGEIVrSWQSYTAKadlaeqknldgSLTKAKVILPPLSNR-----NQW 146 Sphaeroforma ar...
PXF41650      80 TLFP------AP---DEQ--WVQ-RLVEWFSTVQSAVaLSRRQRNA--------------RNARKLPAVNDA-----TSW 128 Gracilariopsis ...
XP_003081432  86 ETELappdwaKP---NRE--WTR-RTVGDFSDLRIHVsRMLASTSTrn--------cSGASGTSAYPRCGDR-----RAW 146 Ostreococcus tauri
ETW83753     147 WEFFAGspasvwdppraakqpkqrevrrlgnddhavppfhrtnaygsstdewvvgtvteeqlaemhdgtrvsdtdprqga 226 Heterobasidion ...
EEH55290     207 DEVVVDdevvvdddd----------------------------------------------------------------- 221 Micromonas pusi...
XP_002504770 183 DTLIRS-------------------------------------------------------------------------- 188 Micromonas commoda
PRW56469     197 QEELAAlsldp--------------------------------------------------------------------- 207 Chlorella sorok...
GAX75712     151 GLICFGpsgdrpddsnaasrqqetststcrlsdnlndeggsg-------------------------------------- 192 Chlamydomonas e...
5_pfamImport 112 DRACFGhaaqaevrgvp--------------------------------------------------------------- 128
XP_005706319 135 ESLCWSydgnrpe------------------------------------------------------------------- 147 Galdieria sulph...
XP_014154423 147 KLIFLGkasltigesdit-------------------------------------------------------------- 164 Sphaeroforma ar...
PXF41650     129 KRILNDek------------------------------------------------------------------------ 136 Gracilariopsis ...
XP_003081432 147 EKLCAEiv------------------------------------------------------------------------ 154 Ostreococcus tauri
ETW83753     227 fasgslqastgnmsgandgvselqsasspspplvprePT----PTLLQYIDHRMSVHLLMYF-TH----------WFNLH 291 Heterobasidion ...
EEH55290     222 -----------------------------dgsgdghsPHwfahESLLLEIDDLTSAALLREH-AR----------AIEAS 261 Micromonas pusi...
XP_002504770 189 -------------------------------------DE----VSAAAAFR-AHARALASRL-SA------------EED 213 Micromonas commoda
PRW56469     208 --------------------------------psaltPE----LQQLQGQDQLQVRRQLHAA-IR----------QVVRE 240 Chlorella sorok...
GAX75712     193 --ggevvnasfaegflssehggalaqpcpniserisgPL----LKTVLAMDQVRVVSLLTWL-IQ----------EFQEL 255 Chlamydomonas e...
5_pfamImport 129 --------------------------aaagaemtqltPGi---CSKIMALEQPEVISLFLRH-SQ----------QLEEH 168
XP_005706319 148 ------------------------------lysidrlP-----LNELSCLDHLRCISLVRLF-ES----------WFRKD 181 Galdieria sulph...
XP_014154423 165 --------------------------vgseastiesrPI----LRAVSTISHKSICSLLGLLaSE----------WRLKP 204 Sphaeroforma ar...
PXF41650     137 ------------------------------------gPL----LSIVLALDFLRVLKLFRII-DHelgampnftcPLSEQ 175 Gracilariopsis ...
XP_003081432 155 ------------------------------------ePP----IGAVLAMDAVTCAHLLRHV-SH----------ALCRY 183 Ostreococcus tauri
ETW83753     292 LEwldsast---------appahiPTES---HA---------RWIFTLLGRVDAFCTADEISGLRGLARV-ClGLVRARr 349 Heterobasidion ...
EEH55290     262 VDddddddddgdrdgsspepspisFSRR---RA---------AWFFALSARVGLPLDAETSAAIRAAAKA-L-SKLRAS- 326 Micromonas pusi...
XP_002504770 214 ELaksae------------pmtpaILHA---RA---------SWFYALAARVGLPLDAETSASVRALARAlA---MRRSk 266 Micromonas commoda
PRW56469     241 EQ----------------------LDPA---AA---------ALLYALSARIEKPLHAGTCALYRQLLRL-C-ASQRAA- 283 Chlorella sorok...
GAX75712     256 QY----------------------ISYT---RS---------QWLFSLAAVLEKPIHCDTGAAFRALLRK-C-CALRVK- 298 Chlamydomonas e...
5_pfamImport 169 C-----------------------PDSLpllRA---------QWLFALAARLEKPCHPEVAAALRAVLRH-C-CKLRGV- 213
XP_005706319 182 SFkssesf-----------kveeeLSRL--------------AWLFGILAAIGPPLDGDTEASIRSILRH---LIVRKRg 233 Galdieria sulph...
XP_014154423 205 PT----------------------ISQL--------------EWAFALFTCLE-TTSPDLTSTLRGIMKQ-L-LDYRQKd 245 Sphaeroforma ar...
PXF41650     176 RRgtast------------ladrfLYQR---RH---------QWLFCLMAVLQPPLSRDSAATLRSILQK-A-AFARHG- 228 Gracilariopsis ...
XP_003081432 184 D-----------------------YDGD---NAdfeeiirllRWFHALCARVDLPLDPDTEAGIRSAMKG-V---ARGRl 233 Ostreococcus tauri
ETW83753     350 ergdgdvkgksTEAHRGMGEVACWMVVCIVVGMWGQQ 386 Heterobasidion irregulare TC 32-1
EEH55290     327 -----------TRRATDPSLPRLQVCYAIAGRYFGQG 352 Micromonas pusilla CCMP1545
XP_002504770 267 -----------VTSSRDPSLPHIQVCLAVAGKYFGQF 292 Micromonas commoda
PRW56469     284 -----------LGSAADPSLPHLNIMIVIAGAYFAQD 309 Chlorella sorokiniana
GAX75712     299 -----------AANKSDPQLPILNTLIAVAGGYFGQD 324 Chlamydomonas eustigma
5_pfamImport 214 -----------VSQAGDPLLPRLNVLIVMAGAYFAQD 239
XP_005706319 234 y--------esMEQTDSNLINIVRTLISVVCNEFHQG 262 Galdieria sulphuraria
XP_014154423 246 tvv-----insYGELDSSLVAGMSLIITIIGRIYGQY 277 Sphaeroforma arctica JP610
PXF41650     229 -----------MTGVDDKRLSHLNVLIAILGTYFGQG 254 Gracilariopsis chorda
XP_003081432 234 ----------sVVSGEDALVAHFNLAIAIGGGYFKQW 260 Ostreococcus tauri
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