Conserved Protein Domain Family
DIE2_ALG10

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pfam04922: DIE2_ALG10 
DIE2/ALG10 family
The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterized in rat as potassium channel regulator 1.
Statistics
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PSSM-Id: 398537
Aligned: 123 rows
Threshold Bit Score: 279.053
Threshold Setting Gi: 124458563
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEQ29325      29 LPDPYLDEVFHVRQAQAYWDHRWKQWDPKITTPPGLYLVSYAITSTSSIlfakpvEL-------SASVLRCINGLVLF-- 99  Microsporum can...
4_pfamImport   1 QPTPFIDEIFHIPQAQKFCNGHFSEWDPKITTLPGMYFISVLILAPLS-------WFggk-slcTVWSLRFINIMFNLvn 72 
EKC40459       8 QQSPYMDEIFHIRQAKHYCHGNFTVWDPMITTLPGLYLITVGILKPFIL------LLgvd-tacSVAGLRLINILFQAgt 80  Pacific oyster
NP_001314762  31 QRDPYMDEIFHVPQAQKYCEGKFTEWDPMITTLPGLYLASVGLIRPVVWl----aDLkgr-vvcSTAMLRFINLLFNSgn 105 zebrafish
XP_011490848  31 QREAYMDEIFHVPQAQKYCQGKFSEWDPMITTLPGLYLVSVGIIKPVAWl----sDLtge-vvcSTAMLRFINLLFNCgn 105 Japanese medaka
XP_003977579  31 QRNPYMDEILHVPQAQKYCHGKFNEWDPMITTLPGLYLVSVGVIKPVVWl----sGLtgn-vvcSTAMLRFINLLFNCgn 105 torafugu
XP_009014810  32 QSEPYMDEIFHVSQARQYCNGNFSHWDPMITTLPGLYLASIGSLKPID-------VLfdvktcgNLYWLRCINLIFCLat 104 Helobdella robusta
KAE8616155    31 QRDPYMDESFHIPQAQLYCQGHFNQWDPMITTLPGLYLASVGMVKPAAWl----fGWsds-vacSSGMLRFINLLFSLgn 105 tropical clawed...
XP_019948028  31 QRLPYMDEVFHVPQAQKYCQGRFTEWDPMITTLPGLYLISVGVIKPVVWl----aDLtga-vvcSTAMLRFVNLLFNCgn 105 Japanese flounder
XP_023206347  31 QRDPYMDEIFHVPQAQRYCKGKFKeWDPMITTLPGLYLVSVGIIKPMTWl----aKLtgs-vvcSTAMLRFTNLLFNCgn 105 southern platyfish
EEQ29325     100 -NALQFTIRRFLSIRQDKSlakgetranpwtLSLNALNICLFPPIFFFSGLYYTDLAALLTVLEVCNIdlgrslprnghd 178 Microsporum can...
4_pfamImport  73 lLISYLILKRLRRENVKPKvedek---vradKIWCSLSIGLFPLLYFYSFLYYTDPGSTTFVLLAYLAcih--------d 141
EKC40459      81 fYVLRAIYKTIHSTPQADNkea------dkvALVTAITLTFFPLLHFFTFLYYTDPGSTFFVLLMYLFhlh--------g 146 Pacific oyster
NP_001314762 106 lYILYLIICKLHMKDKSRSas---------rRMLSALVLSTFPVLYFFTFLYYTDSGSTFFTLFMYLMaly--------g 168 zebrafish
XP_011490848 106 lYLIYLLLCKLHPREKTRTas---------rRVLSALSLSAFPVLYFFNFLYYTDAGSTFFILFTYLMtly--------g 168 Japanese medaka
XP_003977579 106 lYLLYLLICKLHHREKTQAtp---------rRVLSALSLSTFPVLYFFNFLYYTDSGSTFFILFTYLMtly--------g 168 torafugu
XP_009014810 105 lYIISIIVVKLQKQNEIISsw---------hTSLLALNITTFPVLFFFNFLYYTDAGSTFFVLLSYYFhls--------n 167 Helobdella robusta
KAE8616155   106 lYMIYLILSKINCKNKV-Ssf---------kKILSTLTLYAFPTLYFFTFLYYTDTGSTFFVLFAYLMcly--------g 167 tropical clawed...
XP_019948028 106 lYLLYLLICKLHLREKTRTts---------rRVLSALSLSTFPVLYFFNFLYYTDAGSTFFILFTYLMtly--------g 168 Japanese flounder
XP_023206347 106 fYVLYLLISKLHHRDKTRLml---------rRILSAVCLSTFPVLYFFTFLYYTDAGSTFFILFAYLMtly--------g 168 southern platyfish
EEQ29325     179 taKNSlgttimqflsfLVLGLAALVFRQTNIFWVaVFLGGLRVVNTLQARSVVCISsdvwriikgswylnqiydppasda 258 Microsporum can...
4_pfamImport 142 hhKTA-----------GLVSAISIVFRQTNVVWV-MFMAGITVSDQLDDIEDVEKIqaspelhdkla------------- 196
EKC40459     147 nkTLA-----------AFMGGMSILFRQTNIVWV-IFMAGLSAADVIQDWMNNHAHvkkkdktq---------------- 198 Pacific oyster
NP_001314762 169 chKVA-----------ALLGICAVLFRQTNIIWV-AFCASMVVAQKLDETWRTDQSkkrdeklpsq-------------- 222 zebrafish
XP_011490848 169 chKAA-----------ALLGVCSVLFRQTNIIWL-AFCAGTVVAAKMDEAWRVEHTkkreeksaps-------------- 222 Japanese medaka
XP_003977579 169 chKTS-----------AFLGVCAVLFRQTNIIWV-AFCAGTLVAAKMDEAWKAAHTkkrdeksltn-------------- 222 torafugu
XP_009014810 168 vhSLA-----------ACMGAVSIIFRQTNVVWV-VFLFWLTLIPVLNGQRRVIGRnlngskyeleftsd---------- 225 Helobdella robusta
KAE8616155   168 nhKSA-----------SLLGLCAFFFRQTNIIWI-IFCAGNVISEKLTEAWKT-HLkkrdenpsa--------------- 219 tropical clawed...
XP_019948028 169 chKAS-----------ALLGVCSVLFRQTNIIWV-AFCAGTLVAAKMDEAWRVEHSkkrdekspps-------------- 222 Japanese flounder
XP_023206347 169 chKAS-----------ALLGVCAVLFRQTNIVWV-AFCAGTVVAAKMDDVWRMEYTkkrdekppav-------------- 222 southern platyfish
EEQ29325     259 siegkasptdlpgrqprtniltDYFKVGFSLAI--------SF---VAnlsailvavlpYLFFLGCFGLFVLVNGSVVLG 327 Microsporum can...
4_pfamImport 197 -----------ryapnyiavsfRFFAKLLAAVL--------RYllaVDhliliasliwpYLLVLCGFGGFVYINGGIVVG 257
EKC40459     199 ---------------qapltdgQTFQSFLKLLFgdfkhapqKLlrlIGcvim---qclyYIITMVLFGLFVHLNKGIVVG 260 Pacific oyster
NP_001314762 223 -------------vpltingaiRVMRFLLDFLIspnnika------------vvlstwpYIAVAFGFAFFVVLNEGIVVG 277 zebrafish
XP_011490848 223 ------------qvplslcgvkRVLHFSAEFLS--------SP----GhlkavllaawpYAAVAVGFLAFVVWNDGVVVG 278 Japanese medaka
XP_003977579 223 -------------vpltfsgvkKVMLFMFTSLShvkavl---------------fvawpYVAVGTGFLAFVVMNDGIVVG 274 torafugu
XP_009014810 226 --------pvsniklilkniihTNMKFMLALVEdfvd------------------hlfpYCIVIIAFLIFLWFNNGIVVG 279 Helobdella robusta
KAE8616155   220 --------------kgsvseavKALVFLFQYCLsvrniim------------lvqltwpYITLVLGFFVFLSFNGGIVVG 273 tropical clawed...
XP_019948028 223 ------------qvplsfsgakKIILFTLEFLTspghvks------------vllvawpYAVVGVGFLAFVLLNDGIVVG 278 Japanese flounder
XP_023206347 223 ------------rvplssqgvkKVITFSLDFFT--------SP----EtvkevmqvtwpYAVVAAGFLLFVLLNEGIVVG 278 southern platyfish
EEQ29325     328 HKEFHSVGLHLPQMLYIWPYFMFFSWPVILypwaisvwecicqpdpknlRQLMNKLPRLGVVLG-YLAAMITIVHLNTIV 406 Microsporum can...
4_pfamImport 258 DRSSHQAVLHLAQLFYFSGFALAFASPVLItkd--------------kiARFVEMVRERSHECLlYAALSCYVLFHYSHE 323
EKC40459     261 DRSQHEACLNFPQIFYFVSFTVLFLGPYMIrps--------------riINFILFSVNHLTLTVgFLAISYAIVNKYTYV 326 Pacific oyster
NP_001314762 278 DRSSHEACLNFPQFFYFLSFTLIFSLSTSLsyq--------------raVRFLQALKKQPLVYSfLMLTFLFLIWKFTFV 343 zebrafish
XP_011490848 279 DRASHEVCLNFPQIFYFFCFCLLLSFPVSLcfq--------------rvLRFLQAVRKQPLLFLlLASASLLLVWKFTHV 344 Japanese medaka
XP_003977579 275 DRTSHEACLHFPQLFYFFSFALFFSFPVSLsls--------------rvRRFLEALKKRPLFFLsLTCIALLLVWKFTYT 340 torafugu
XP_009014810 280 AKLDHEASFHCSQLLYFFAFSFFFFLPLISvsn--------------tlSDFLKHIKKRTTFIVaSVIAITTIIHYTTMS 345 Helobdella robusta
KAE8616155   274 DKTSHEACLNFPQLFYFLGFTLIFSFSHLFspq--------------klKEFIKSVWKQPLIYMaLAGISVILIWKFTYV 339 tropical clawed...
XP_019948028 279 DRTSHEACLNFPQLFYFLSFTLFFSLPVSLcyh--------------rsLRFLQSLKKQPLLFLfITGVLLLLVWKFTFV 344 Japanese flounder
XP_023206347 279 DRMSHQVCFNFPQVFYFFSFTYFFSLPVSLclh--------------rtLRFRNSLKRHPLFFSvITIVSLLLVWKFTYV 344 southern platyfish
EEQ29325     407 HPFTLADNRHYVFYIFRL-LLRHPLIKYAVTPIYlLCGWATIAAFN-SRSAsisselaqtpskqkgskeldkvqaersip 484 Microsporum can...
4_pfamImport 324 HPYLLADNRHYVFYLWRLfLGRSv-IRYVAVPVYmFAAWSINDSLSkNCTS----------------------------- 373
EKC40459     327 HLYLISDNRHYTFYVWSKiYERLPQIRYALIPSYyYGIFSLLQTM--KYKN----------------------------- 375 Pacific oyster
NP_001314762 344 HKYLLADNRHFPFYVWKNiFRRHDAVRYLLVPGYvFAMWNFLDTL--RSKS----------------------------- 392 zebrafish
XP_011490848 345 HKYLLADNRHYPFYVWKNlFRRHQLVRFLLVPAYiYAGWNFLDSL--KSRS----------------------------- 393 Japanese medaka
XP_003977579 341 HSYLLADNRHFPFYVWKRiFQRHELVRFVIVPAYvFAGWSFADSF--KLRS----------------------------- 389 torafugu
XP_009014810 346 HKYLLADNRHYIFYIWKNvFQKHWCIRYLLAPVYlFAMYSLWRLF--KSIN----------------------------- 394 Helobdella robusta
KAE8616155   340 HKYLLADNRHYTFYVWRKiFQRHELVKHLLVPGYlFAAWSFADSL--KGKS----------------------------- 388 tropical clawed...
XP_019948028 345 HKYLLADNRHFPFYVWKKlYQRQELVRFLLVPVYvFAGWNFLDSF--RSRS----------------------------- 393 Japanese flounder
XP_023206347 345 HKYLLADNRHFPFYIWKNiYQRHKLIRFLLVPAYiFTGWNFLETL--KSRS----------------------------- 393 southern platyfish
EEQ29325     485 sgasirTSFVLLWLVSTSLSLITAPLVEPRYFIIPWVVWRL 525 Microsporum canis CBS 113480
4_pfamImport 374 -------LWKVVYIICVSCQTAPQKLLEFRYFILPYIVFRI 407
EKC40459     376 ------VFWKLVFIICLFASTIPQKLLEFRYFILPYLLYRL 410 Pacific oyster
NP_001314762 393 ------LFWCLAFCACLVAATVPQKLLEFRYFIIPYLLYRV 427 zebrafish
XP_011490848 394 ------LFWTLAFFSCLLVSTVPQKLLEFRYFIVPYLMYRL 428 Japanese medaka
XP_003977579 390 ------LFWNLAFLSCLVAATVPQKLLEFRYFIVPYLMYRL 424 torafugu
XP_009014810 395 ------VLWKFGFICCLAAALVPASLIELRYFIIPFLFLRL 429 Helobdella robusta
KAE8616155   389 ------IFWLLMFYSCLLAAMVPQKLLEFRYFIVPYIIFRL 423 tropical clawed frog
XP_019948028 394 ------LFWSLAFLACLVAATVPQKLLEFRYFIVPYLMYRL 428 Japanese flounder
XP_023206347 394 ------FFLSLAYLTCLVLATIPQELLEFRYFIVPYLMYRL 428 southern platyfish
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