Conserved Protein Domain Family
Mak16

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pfam04874: Mak16 
Mak16 protein C-terminal region
The precise function of this eukaryotic protein family is unknown. The yeast orthologues have been implicated in cell cycle progression and biogenesis of 60S ribosomal subunits. The Schistosoma mansoni Mak16 has been shown to target protein transport to the nucleolus.
Statistics
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PSSM-Id: 398509
Aligned: 123 rows
Threshold Bit Score: 54.1207
Threshold Setting Gi: 674573788
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6FUT9       145 APKVKRREMNRERKALVAAKIEESISKELLNRLKSGAYSNadktltPLNVDENIWNKIMGKL---Geed--meGVSAdee 219 [Candida] glabrata
XP_003291496 137 NKKAERRDKTRENKALVAAHLTVNIKKELLSRLSKGTYSE------MNYFPEEVFNEVLn-----KegdqdelDEEEiee 205 Dictyostelium p...
EGG16980     139 QKKADRRDARREQKAMVAAQLTVNIKKELLERLKKKTYGD------LYYFPEKVFNEVL------Ee-----dGEQDemn 201 Cavenderia fasc...
ESS34463     138 KQKTERREKAREKKAEVAAHLEDVIESELLKRLQQGVYGT------LYNFESEKTAEA----------------EADqee 195 Toxoplasma gond...
EGG12030     148 NNKTERREKARESKALSAARLTKTLEKELISRLKSKSYGDl-----PLNVNESIWKSVLENEkteTe-----lEie---- 213 Melampsora lari...
XP_003338067 148 KSKTERRERAREAKALSAARLTKTLEKELIGRLKSKTYGDa-----PLNVNEDVWRSVLEGEkrkEleq--enEle---- 216 Puccinia gramin...
XP_001728903  18 KKKTERREATRETKALRAAKLEKSIERELLERLKRGAYGDa-----PLNVNEDVWNAVLENAq--Arv---pdAESSale 87  Malassezia glob...
GAC75333     140 KKKTERREDRREFKALKAARLEKSIEKELLERLKSGAYGDa-----PLNVNEDVWMQVLENRn----------kENKdld 204 Moesziomyces an...
CBQ70169     140 KKKTERREERREFKALKAARLEKSIEKELLDRLKSGAYGDa-----PLNVNEDVWMQVLENRnr---------dSAQele 205 Sporisorium rei...
CCF49863     140 NKKTQSREQRREMKAIKAARLEKSIEKELLERLKSGAYGDa-----PLNVNEHVWMQVLENRn-----------KSQgve 203 Ustilago hordei
Q6FUT9       220 eeESDVE----------------REIEYIE-DT-Ee---EEEVDLDN----LEK 248 [Candida] glabrata
XP_003291496 206 eeELEEEyedeid-----dlengGDIEYVEg---------DDDEFDDdddefda 245 Dictyostelium purpureum
EGG16980     202 seEEEEEfeee--------meegGATEYVDgGSdEe--fYDDDEDDEdyddieg 245 Cavenderia fasciculata
ESS34463     196 eeVKQDKaekrgvvafeeedeeeELSEYSEsEGsEdfdfDESDEEED----IED 245 Toxoplasma gondii VEG
EGG12030     214 lkDEMTDedgsge----deeeeeFEREFVS-DFeE-----SDEDEDD----LED 253 Melampsora larici-populina 98AG31
XP_003338067 217 leDEETDeesdd-------gdeeEEREFVS-DL-------EESDLED----MED 251 Puccinia graminis f. sp. tritici CRL 75-3...
XP_001728903  88 leEELSDeeaeed-----idamdAEMRAINedddeygqrefisddedeseddle 136 Malassezia globosa CBS 7966
GAC75333     205 leDEESDee-------------------------------leEDLEEmdrmMEE 227 Moesziomyces antarcticus T-34
CBQ70169     206 leDEESDee-------------------------------leEDLDEmdrmMEQ 228 Sporisorium reilianum SRZ2
CCF49863     204 lqDEESQee-------------------------------leEDLDEmdrlMGQ 226 Ustilago hordei
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