Conserved Protein Domain Family
Moulting_cycle

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pfam04870: Moulting_cycle 
Moulting cycle
This family of proteins plays a role in the moulting cycle of nematodes, which involves the synthesis of a new collagen-rich cuticle underneath the existing cuticle and the subsequent removal of the old cuticle.
Statistics
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PSSM-Id: 398506
Aligned: 22 rows
Threshold Bit Score: 343.959
Threshold Setting Gi: 309365890
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFP02723      165 PFTLITKQITKSIRALKNK--KEERGWRQIMVDVKKTGEVIEKRRKVKEMIGKSVRSRSAKPKKlylsprkplanndyea 242  Caenorhabditi...
2_pfamImport    1 PFTKITKQITKTIRALKNK--KDERGWRQIMVDVKRTGDLVEKRNKVKEMIGKSVRGRTRSnarkp-------------- 64  
O76555        187 gmTKLAKSLTNTVRAMKNKt-ERAEPWVEAVGRIKKLGEEAKREKKNREVMKKRLKQMIDNTPAefvdpr---------- 255  Caenorhabditi...
CRZ25494      187 PFGILGKHLSKMTRIIKNK--EPNSSWKKTMYEIESLKRREQEKNDFAEKLKKRFPFSFKNTEPkltpe----------- 253  Brugia malayi
CAP22655     1036 PFSNIAKHLTNLVREKKNKenEPKKKWQTVINEIKEELDRIKKKKKDREEFKNIFSKYSRTMKMlgld------------ 1103 Caenorhabditi...
CAP23802      188 PFGLVTKHLTSAVKLLKHT--DKVSKWQDTIERIAKKADVIKEQKKMEDFMQRRLSVFTDAAA----------------- 248  Caenorhabditi...
Q9XU60          3 PLGVLAKHLSHTLRLIKNK--RTTSKWEDTISRISEKASQIKQQKDMERRIRKQRGY----------------------- 57   Caenorhabditi...
EFP01901      177 PLGVLAKHLSHTLRVIKNK--RTTSKWGDTITRISEKAQKIKERKEMQRLLEKRMNVFTENGE----------------- 237  Caenorhabditi...
EGT56201      176 PLGVLAKHLSHTLRLIKNK--RTTSRWEDTITRISEKAQKIKERKELEKLFQKRMNVFQEASE----------------- 236  Caenorhabditi...
CAP25584        2 rIHLLAKHLSHTLRIIKNK--RNTSKWEDTITRISEKAQKIKKRKEMEKMFQKRMNVFTEAAEGl--------------- 64   Caenorhabditi...
EFP02723      243 lddpiqMTNEIiqtSSESDKKIDAeELLKRFQD-----HPEDILNDDAQGLLNMTGQ-ETEAVLRIKLIRE--------- 307  Caenorhabditi...
2_pfamImport   65 -ladnnTSDEQlenDS---KPVNMdEMFQRLQD-----HPEEILKNDAPRLLNMTGE-QSEAVGRIKLIRD--------- 125 
O76555        256 ---------------------------------kpvalKQAEMEDENNEIAKLMRKKeADEIRVPLKFLRK--------- 293  Caenorhabditi...
CRZ25494      254 ---------------------------------ekllaKELHISNHLLQGLDKNSMK-TKKTLEIIQLFKR--------- 290  Brugia malayi
CAP22655     1104 ---pkqAFEKAvsfFLQCRTRIPNfDIIQGMSS-----LGEEIAD-SSNTTEPMSEE-ETALKKPLMMIRDgkfrvldfe 1173 Caenorhabditi...
CAP23802      249 --------------KMKQNKKLAKdDSLKEMNDleefiDNDQIRDVLRNRKEKITEQ-DKLLMIPMKMMRD--------- 304  Caenorhabditi...
Q9XU60         58 --------------ELPEEKPVPLdKDVRELIDlekyiGDEDLKSMVRHKSGNLTEQ-DRAMLIPMRLIRG--------- 113  Caenorhabditi...
EFP01901      238 --------------NFEQLKS-PEdDEAKELIDlekyiDDDDLKSMVRKKAGNLTEQ-DRMMLIPMKLIRE--------- 292  Caenorhabditi...
EGT56201      237 --------------DMKQ--SRILdHDAQELLDlekyiGDDDLKSMVRKKAGNLTEH-HRMMLIPMRLIRQ--------- 290  Caenorhabditi...
CAP25584       65 ---------------------nPNdSDAQELMDlekyiRDDNLKSMVHKKAGNLTDQ-DRMMLIPMRLIRG--------- 113  Caenorhabditi...
EFP02723      308 -----AVKLGLSLGGQNVSGFDQKSMKFASPRFFAIAPEEHKKENDTvsfireqdtceltcsfsqINILSPSLFSLHDEG 382  Caenorhabditi...
2_pfamImport  126 -----AVKLGLSLGGQNVRGFDQKSLRFASPRFFAIAPEEHKRKDDT------------------VNILSPSLFSLHDEG 182 
O76555        294 -----AVKTALMLGGQNVTDFDQKTLKMVSPRMMSIVPE--QEDESL------------------FNLLSPSLFSLHDEG 348  Caenorhabditi...
CRZ25494      291 -----AIKLAMVLNGANGTKLENKTLRFGSPRLLSLVPD---NVNDQ------------------INILSPSLLSMHDKG 344  Brugia malayi
CAP22655     1174 nkkssGVKLGMMLAGKNVSNFDERKISLMSPQFMSVLPD--EQANDT------------------VNLLSPSVFALHEKG 1233 Caenorhabditi...
CAP23802      305 -----AAKMSLGMTGYNTTDFDRKIVRIISPRIMSVIPQEEEAKNNE------------------IDVLSPSLFALHDDG 361  Caenorhabditi...
Q9XU60        114 -----AAKLGLSMTGYNTTDFDRKVVRIFSPKLMSVVPESEEARKNE------------------IDILSPSLFSLHDDG 170  Caenorhabditi...
EFP01901      293 -----AAKLGLSMTGYNTTDFDRKVVRIFSPKMMSVIPTSDETKKDE------------------IDILSPSLFSLHHDG 349  Caenorhabditi...
EGT56201      291 -----AAKLGLTMTGQNTTDFDRKVVRIFSPKMMSVVPTSDDAKKDE------------------IDILSPSLFSLHQDG 347  Caenorhabditi...
CAP25584      114 -----AAKLGLTMAGQNTTDFDRKVVRIFSPKMMSVVPANEDEKKDEvgagysn----pytinfqIDILSPSLFSLHHDG 184  Caenorhabditi...
EFP02723      383 SPDEQKTSLVKLLGDK----EGIDKDSFMDLLTELTGVADTVDDAAQKASRE-----SEGTLINVKGEEINVSRENL--- 450  Caenorhabditi...
2_pfamImport  183 TQEEKSLSLPKIFDNTitqhDGAEKDSFMDLITEISGVADAVDDAAQKVARE-----SEGVLMKSDGAEISVSRENV--- 254 
O76555        349 EGIEKLTSLPHLLKKL----DNHGQNAWMDFIVEAAGVSDEVTKTEKVFREK-----KEKELRGTDGVPLYFTKENA--- 416  Caenorhabditi...
CRZ25494      345 KGLEALTSVPELLKAA----GNRDYEEWLSFIIEASGTTDAIHKLKEKNELDwlppgYKSMPRGIDGQPMFFTKENV--- 417  Brugia malayi
CAP22655     1234 TELDQMLSLSKAMRFL----SENGHDEWMNLILEASGVTEAVEKMRVRNRREe-------------------TRNRVvpk 1290 Caenorhabditi...
CAP23802      362 SGVEKKASLGNLLGSLt---NNKDSQDFLDFIVEATGVNEAMERVEKKIGEYrr-lkDDAMGRGPEGQPLYFTKENV--- 434  Caenorhabditi...
Q9XU60        171 TADEKEVSLQNLLGSLs---TNKDTSQLLDFIIEATGVDEAMERVETKIDE------SFGSERGPEGQPLYFTKENV--- 238  Caenorhabditi...
EFP01901      350 SEIEKEVSLQNLLGSLt---AHKDTSDLLDFIIEATGVDEAMERVETKIEE------SFHSERGPEGQPLYFTKENV--- 417  Caenorhabditi...
EGT56201      348 SSIEKEVSLQNLLGSLt---ANKDTSDLLDFIIEATGVDEAMERVESKIEQ------SFQQERGPEGQPLYFTKENV--- 415  Caenorhabditi...
CAP25584      185 SEIEKEVSLQNLLGSLt---ANKDTSDLLDFITEATGVDEAMERVEQKIEQ------NFQSERGPEGQPLYFTKENV--- 252  Caenorhabditi...
EFP02723      451 TKVYGEeNYRKMKVLEKLHGMYTDE---------------QvsmMNHFNKSGYAIMTDKQRDMVYGSGAPFENKLTLEAG 515  Caenorhabditi...
2_pfamImport  255 TRIYGEdNYRKMKVLEKMHGMYTEE---------------Q---MHHFNKSGYAIMNDKQREMMYGAGAPFENAQTMKAG 316 
O76555        417 TKILGNeEKSKIEVFEDLDKSYSEE---------------Q---KKKLNDDGFAFLTEKQMERLYGKESPYKHTKALKKF 478  Caenorhabditi...
CRZ25494      418 TEFDPE-LAREVELFENLTHSLTPK---------------Q---LTDFNTTGFSMMTPKQLTMFYGPQSPLNDSKALNFF 478  Brugia malayi
CAP22655     1291 XXXXGEyETSKIDSMEALHKSMSAAqvlyrnwqlswsllfQ---MHEMNTTGFAIMTPFQISQFYGPRSPYNDSYAYKNY 1367 Caenorhabditi...
CAP23802      435 TEKYPH-EAKKIDMFEALDKTYSDE---------------Q---LKEMNRTGYTIMRHDQMDLIYGKGSVGENEKFLKTA 495  Caenorhabditi...
Q9XU60        239 TANYPH-EAQKLEIFEALDRTYSTS---------------Q---LNEMNRTGYAIMRHDQMDLIYGDQSIAKNPKFLKQA 299  Caenorhabditi...
EFP01901      418 TAQ----ESKRIEIFEALDTTYSEN---------------Q---LKEMNRTGYTIMTHEQMDLVYGNYSIMENQKLLREA 475  Caenorhabditi...
EGT56201      416 TEKYPH-EAKKIEIFEALDKTYSEE---------------Q---LKEMNRTGYTIMRHDQMDLIYGNKSVMRNLEFLERA 476  Caenorhabditi...
CAP25584      253 TEKYPL-EARKIETFELLDKTFSME---------------Q---LREMNRTGYTIMRHDQMELIYGNNSVHKNPEFLNRV 313  Caenorhabditi...
EFP02723      516 RNLTMPKAKKALHTVIQEIGKGNIKV 541  Caenorhabditis remanei
2_pfamImport  317 QNLTMARAKRALHTVIHEIGKGNIK- 341 
O76555        479 KRL-RDDPEKYIEKDIRALAEAEkfr 503  Caenorhabditis elegans
CRZ25494      479 LSLSEDDMHRHILSDIRDMAKMNssl 504  Brugia malayi
CAP22655     1368 RNIRRNDIPHMLENNIHRMAREEQAF 1393 Caenorhabditis briggsae
CAP23802      496 KALSRPQIDRAIMSTIKDLAHEKVKF 521  Caenorhabditis briggsae
Q9XU60        300 KALSRAEIDRSIMSTIKDLAKEKVKF 325  Caenorhabditis elegans
EFP01901      476 KRMSRPEIDRSIMQTIDDLAKEKVKF 501  Caenorhabditis remanei
EGT56201      477 KQLSRSEIDRNIMGTINDLAREKVKF 502  Caenorhabditis brenneri
CAP25584      314 KGMSRSEIDRNIMGTIGDLAKEKIKF 339  Caenorhabditis briggsae
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