6YUF,1W1W


Conserved Protein Domain Family
Rad21_Rec8
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pfam04824: Rad21_Rec8 
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Conserved region of Rad21 / Rec8 like protein
This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.
Links
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Statistics
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PSSM-Id: 335912
Aligned: 14 rows
Threshold Bit Score: 60.4242
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6YUF_B  568 TEGEKVSFQTLS-AGCNREEAVQLFFDVLVLATKDVISVKQdVAIQNEITLTAKRGM 623  Schizosaccharomyces pombe 972h-
P36626  503 NNGRITFSSLLP-NDLKRPVVAQAFSHLLSLATKSAFLVKQ-DKPYSEISVSLNLKS 557  Schizosaccharomyces pombe 972h-
O95072  492 ANREPDFSSLVS-PLSPRRMAARVFYLLLVLSAQQILHVKQ-EKPYGRLLIQPGPRF 546  human
Q8C5S7  536 ANKELDFSSLVP-PLSPRKLASRVFYLLLVLSTQKILLVEQ-QKPYGPLLIRPGPKF 590  house mouse
Q61550  578 TGAESISLLELC-RNTNRKQAAAKFYSFLVLKKQQAIELTQ-EEPYSDIIATPGPRF 632  house mouse
O96689  656 iAKDSLELSQLT-SGNSRKQAAQKFYSLLVLKKFKVLHIDQ-SAPYADITITRGPTF 710  fruit fly
Q8W1Y0  972 nGKNVLVADKLL-AGKTRKEASRMFFETLVLKTRDYIQVEQ-GKPYESIIIKPRPKL 1026 thale cress
Q9FQ19  633 HPSGDLSLSEIL-AGKTRKLAARMFFETLVLKSRGLIDMQQ-DRPYGDIALKLMPAL 687  thale cress
1W1W_E   62 TDVLKSQANTEP-ENITKREASRGFFDILSLATEGCIGLSQ-TEAFGNIKIDAKPAL 116  baker's yeast
Q19232  542 FEVTLDS--MIPvAATSRREAARTFYTVLELLKERKIKATQ-RAPYENIDLLLSTDD 595  Caenorhabditis elegans
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