Conserved Protein Domain Family
TIMELESS

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pfam04821: TIMELESS 
Timeless protein
The timeless gene in Drosophila melanogaster and its homologs in a number of other insects and mammals (including human) are involved in circadian rhythm control. This family includes a related proteins from a number of fungal species.
Statistics
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PSSM-Id: 398476
Aligned: 126 rows
Threshold Bit Score: 110.729
Threshold Setting Gi: 325078474
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004177854   39 YKLGDDCLACLKDLKRWFKLvddQQNRWDVALAAAEYQILMDDIIPILID-WEDksrlasklskinkstngsignndqti 117  Tetrapisispor...
G5EDN3         20 YSREPDCYESIRDLIRYLRE---DGDDHTARIECGRHNLVEQDLVPMVKCeDLT-------------------------- 70   Caenorhabditi...
EDV93232       23 YQAEPDAAEGLKHLIWILRR---DVDNHEYRRHLGRSKVLQTDLVYMLPD-YVE-------------------------- 72   Drosophila gr...
EDS41292       23 YHMEPGTINGLKHLIWILKR---EGEDNEYRRYIGQKKVMQTDLIPMLMS-NFD-------------------------- 72   southern hous...
Q16VM6         23 YHMEPDAIMGLKHLIWILKR---DSDDHEYRRYIGQKKVMQTDLIPMLMS-NFD-------------------------- 72   yellow fever ...
XP_001689129   23 YKMDPEAVQGLKHLIWILKQ---DRPAHECRRYIGGKRIVQTDLIPMVIS-NFD-------------------------- 72   Anopheles gam...
ETN60376       23 YYPDPQAIDGLKHLIWILRN---DGPDHEFRRYIGEKRLVQTDLLPFLLH-SFH-------------------------- 72   Anopheles dar...
XP_016662949   23 YCIDPQCSEAVRDLIKFLRR---DGDDHEIRRHLGTANIVETDLLPILVE-YSN-------------------------- 72   pea aphid
1_pfamImport    2 YHLEPHCKETIKDLIRYLRR---DEASYDIRRYLGNAKLLQTDLLPIAQC-HHN-------------------------- 51  
EFX80319       21 YFKDQYCLEALKDLIRYLRR---DDDTIGIRRELGQMKLVQTNLIPILCE-YHS-------------------------- 70   common water ...
XP_004177854  118 siSKIhhdkIALNCLQLLVLMTWPLVL-NEQ---STIEQILQYAELKKYQLLYKKMILSVedgKVLRAVIRLAANVI-RI 192  Tetrapisispor...
G5EDN3         71 --DDE-----FDIAIRLMVNLCQPAIStMRGkppADRDQWKMYWELEENLRRAKTAFSDA---HFFTAIKKRIDNYFiDT 140  Caenorhabditi...
EDV93232       73 --HEE----LADLLIRLLVILTNPTLLlYRDgppNDNHGRKVFLELIDILQGYKAAFAKD---KIWTALFEKLKQSL-ET 142  Drosophila gr...
EDS41292       73 --NPE----VADVLLRLIVNLTYPVLLlYNGnypKDSVGRRNFHRLVEILQTYKEAFAVQ---QAWIALGDRLQKVL-KM 142  southern hous...
Q16VM6         73 --NPD----VADVLLRLIVNLTYPTLLlYQGtqpKDAVGRRNYLHLVEILQGYKEAFAVQ---QAWAALGDRLQKVL-QV 142  yellow fever ...
XP_001689129   73 --KPD----VVDVLLRLLVNLSFPTLLlYNGnypKDAAEQRKFIRLMEICEEYKEAFSLK---SVWSVLGDRLEKIL-HT 142  Anopheles gam...
ETN60376       73 --EPD----VADVVLRLLVNLTFPTDLiYKEnhpKNASDRKKMLQLMEIAEGYKEAFTVN---AVWSVLGEKMQSIL-RI 142  Anopheles dar...
XP_016662949   73 --NSD----LFDLIIRLLVNLTTPALLiYNEqppIEKTQSQNYLQIVSHLQKYKRAFTDI---NVWKVIVNKLAEVI-QA 142  pea aphid
1_pfamImport   52 --DKE----LFDLVLRLVVNLTNPALLlYNEvvpDDKNEHNIYLEIVSHLQNYKEAFCNQ---KLWVPITQRLGSLL-NK 121 
EFX80319       71 --DEA----LFDVALRLLVNLTNPTLLlFNEempTDKVERNYYLQHVGHLQSYKPVLASD---KFWVVLTDKLKLLL-VK 140  common water ...
XP_004177854  193 DKLHRTARDNMILKLILNFLKNIASLEPG---ELAISPKMRsrirnisnydmlppnvtmddiSLNSVITAFHKNKVFKLI 269  Tetrapisispor...
G5EDN3        141 EYEDRDERLRLVVERIVLLIKYVFSINPDtseGRRTRIEDS---------------------SHDRVIIAFLESGIDKTL 199  Caenorhabditi...
EDV93232      143 AFAIRSEEQNLLIERILVLVRNVLQVPANpeaECRADNDAS---------------------LHDQVIWALHQTGMLDLV 201  Drosophila gr...
EDS41292      143 DWAERTEEQELIIERILMLIRNILQVPSCveaENRYEKAAS---------------------VHDQVLWALHQTGILNLV 201  southern hous...
Q16VM6        143 DWAERIEEQELIIERILTLTRNVLNVPSNmdmEKRFDNDAS---------------------LHDQVLWALHEAGVLDLI 201  yellow fever ...
XP_001689129  143 DWALRSEADGLIIERILVLIRNVLQVPANverEKRFDNDAS---------------------QHDCLLWALHQAGILDII 201  Anopheles gam...
ETN60376      143 KSLERSEAQAITVERILMLARNILQVPANvekEKQLDNEDS---------------------LHDRLVWALDQTCTINIV 201  Anopheles dar...
XP_016662949  143 EYHEKGEEKVLSTVRLLILVRNILHVPADndaECRPDNDAN---------------------LHDQVLWALHQSQLIDII 201  pea aphid
1_pfamImport  122 NFLDRDEDDNRTIERILILVRNVLHVPTNavnEWRPDNDAS---------------------VHDQVIWAFHQSGLLDLL 180 
EFX80319      141 EPEDRMEDDKLLTERILILIRNILDIPITpedEKRTDDDAS---------------------VHDQVLWSMHLSGMEDVI 199  common water ...
XP_004177854  270 LTLSSSISrefDQdfiNIPLLELLFYLTKNIDQIEIFkvsqhcripksssilantdnsTMPVDAKNCs-sAGFELSSLLN 348  Tetrapisispor...
G5EDN3        200 MHIANQPR---EKe-fHVTILDIFALILKEQTAEDLAt--------------------KSEEVSTAEqkkTEEEFRKIIE 255  Caenorhabditi...
EDV93232      202 LFIVSSPD---EEq-fHLHGLEIICLLFREQSAESLAda------------------sL--QRSLSEkqrDQQELLAARR 257  Drosophila gr...
EDS41292      202 LYILGSEH---EHq-yHLHSMEITCLIFREQTAISLAda------------------qL--TRTAAEknrDELELIMSRK 257  southern hous...
Q16VM6        202 LYILGSEH---EHq-yHLHALEITCLAYREQSATSLAda------------------sY--QRSATEkhrDELELLAARK 257  yellow fever ...
XP_001689129  202 LYILGSPH---ENr-fLIHTLEILSLAYREQSAVHLAda------------------tL--QRTNTEkktDELLLIKARQ 257  Anopheles gam...
ETN60376      202 SYILGSSS---EQq-yFMHALEIIYLVFREQQPANLVna------------------tM--QRIASEkqeDEVKLLEALQ 257  Anopheles dar...
XP_016662949  202 MYITCSAN---EEq-yYLHALEIISLMLRDQKAAELAna------------------sV--NRTETEkqrDEHDLKMVMD 257  pea aphid
1_pfamImport  181 LYIASSTN---ESn-fSLHLLEIICLLVREQPPSLLAkt------------------aS--QRSVEEknrDDEELLKIRQ 236 
EFX80319      200 IYLASNEN---ERh-fCMHVMEIISLMLREQNPASLAqt------------------aA--QRSVAEkqkDTEELVAMVQ 255  common water ...
XP_004177854  349 KERELKKNLI-N----GTSSRHSRFGALLSI 374  Tetrapisispora blattae CBS 6284
G5EDN3        256 NHVVKETQKRk---------SFSRFGGSYTI 277  Caenorhabditis elegans
EDV93232      258 RENARRQARPpPg-------RHSRFGGTYVI 281  Drosophila grimshawi
EDS41292      258 REKAHQQVRIpVa-------RHSRFGGTYVV 281  southern house mosquito
Q16VM6        258 REKAKQLSRIpAa-------RHSRFGGTYVI 281  yellow fever mosquito
XP_001689129  258 PTAAAAAATTpAalgkPPAGRHSRFRGTYTF 288  Anopheles gambiae str. PEST
ETN60376      258 QPKTAKLPLPp---------RHSRFRGTYMs 279  Anopheles darlingi
XP_016662949  258 KERKEKMDKLkKys----gsRHSKFGGRYVV 284  pea aphid
1_pfamImport  237 SESLAKQQKVkKfl----gtRHSNFGGTYVM 263 
EFX80319      256 KESSEREARYkKmt----asRSSIFRGTFCV 282  common water flea
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