Conserved Protein Domain Family
HNF-1_N
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pfam04814: HNF-1_N 
Hepatocyte nuclear factor 1 (HNF-1), N-terminus
This family consists of the N-terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Links
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Statistics
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PSSM-Id: 398470
Aligned: 19 rows
Threshold Bit Score: 177.271
Threshold Setting Gi: 528505848
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005169889  13 EQIDLLQRLRRSGMTKQEILHALDTLDRLDREHVEK-FGHRHAhggtsa-------inhssNATTSSNSCTTSsnnlta- 83  zebrafish
XP_006631284  13 EQIDLLQRLRWSGMSKPQILHALESLERLDSEQSHKpPQPRPPcydn--------------hsgSTFEPTAAAsssssss 78  spotted gar
Q1L9E9        38 EQIDLLQRLRLSGMTKPQIIQALESLDRLDPDH-------RTPccnnh---------stqpSAPTSAAPAAPSsssss-- 99  zebrafish
XP_005450823  43 EQIDLLQRLRLSGMTKPQIIHALESLERLDPEH-------RPShcdsh--------papsnNAPATAAPAPSSsssssas 107 Nile tilapia
CAG05992      39 EQIDLLQRLRLSGMTKPQILHALETLERLDPNH-------RPSrcs------------sqaTTPASAPTAAPSsssstss 99  spotted green p...
XP_015201190  13 EQIDLLQRLRRTGMTKHEILHALDTLDRLDREHGDK-FGRRPAyggg-----------ggsGTTTTTTTSTNNsnnvaa- 79  spotted gar
NP_919353     12 LQQELLSALLDSGVTKDVLVQALEDLCPCPAEFGIKiEK-PLSpssanggs---dcgdskpVFLTLTGAQGKg------- 80  zebrafish
XP_011480690  12 LQQELLSALLDSGVTKDVLIQALDDMDPSPPSFGVKlENLPLSpaapqsgkmngadpdskpVFHTLTNGHGNk------- 84  Japanese medaka
PNJ06179       8 LQQELLSALLSSGVTKEVLVQALEELLPS-PNFGVKlETLPLSpgsgae-------pdtkpVFHTLTNGHAK-------- 71  Sumatran orangutan
1_pfamImport   1 LQQELLSALLSSGVTKEVLVQALEELLPS-PNFGVKlESLPLSpgsgara-----ptpkagSFHTAPr------------ 62 

XP_005169889  84 sssttSTATQtgfrgnGLSPSPSNSYETSPPPtaptsmpvvaplvqngrdalasmsngklspprftvsnvssrafpfepp 163 zebrafish
XP_006631284  79 lssftSATTQtqs--laASPSPSNSYEASPPPlypagggq--------------------------------rsfsydla 124 spotted gar
Q1L9E9       100 sssltSATTQtpv--idAALSPSNSYDASPPPlyppsgvq--------------------------------rsfsydla 145 zebrafish
XP_005450823 108 slslaSATTQtsg-ldGAALSPSNSFEASPPPlypptvavq------------------------------rsfsydmmg 156 Nile tilapia
CAG05992     100 slslaSATTQtsg-ldGAALSPSNSYEASPPPlyppsaavq------------------------------rsfsydamg 148 spotted green p...
XP_015201190  80 sssttTIATQtq--yrGLSPSPSNSYDTSPPPsaatanqngresmsatpngkl-------spsrytvnsvgarsysfeat 150 spotted gar
NP_919353     81 -----GKLSG------DEGSEDGDDFDTPPIL------------------------------------------------ 101 zebrafish
XP_011480690  85 -----GKLSG------DEGSEDGDDYDTPQIL------------------------------------------------ 105 Japanese medaka
PNJ06179      72 -----GRLSG------DEGSEDGDDYDTPPIL------------------------------------------------ 92  Sumatran orangutan
1_pfamImport  63 -----RRASG----------GTGDDYDTPPIL------------------------------------------------ 79 

XP_005169889 164 DE--EMDI-DD------RVEELMRMDSAIIKEEIKAFLGNRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYR 234 zebrafish
XP_006631284 125 EDmgDWDV-EE------KVEEYMRRDSNVVKEEIKVFLNNRRISQAIVGQVTGISQSYISQWLLqQGLEMSDPKRRAFYR 197 spotted gar
Q1L9E9       146 EE--DWDL-EE------KVEEYMRRDSNLVKEEIKAFLNNRRISQAIVGQVTGISQSYISQWLLqQGLEMSDSKRRAFYR 216 zebrafish
XP_005450823 157 EE--DWDL-EE------KVEEYMRRDSNLVKEEIKTFLNNRRISQAIVGQVTGISQSYISQWLLqQGLEMSDSKRRAFYR 227 Nile tilapia
CAG05992     149 EE--EWDL-EE------KVEEYMRRDSNLVKEEIRAFLNNRRISQAIVGQVTGISQSYISQWLLqQGLEMSDSKRRAFYR 219 spotted green p...
XP_015201190 151 EE--DLDI-DD------KVEELMRRDSSIIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYR 221 spotted gar
NP_919353    102 RElqSLNT-EEaaeqraEVDRMLSEDPWRVARTIKGYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTAKRAALYT 179 zebrafish
XP_011480690 106 KElqSLNT-EEaaeqraEVERMLAEDPWRAARMIKGYMQQHNIPQREVVDITGLNQSHLSQHLN-KGTPMKTQKRAALYT 183 Japanese medaka
PNJ06179      93 KElqALNT-EEaaeqraEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYT 170 Sumatran orangutan
1_pfamImport  80 KGaaGRSTpKEaaeqraEVGRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYT 158

XP_005169889 235 WYQL 238 zebrafish
XP_006631284 198 WYLl 201 spotted gar
Q1L9E9       217 WYLl 220 zebrafish
XP_005450823 228 WYLL 231 Nile tilapia
CAG05992     220 WYLL 223 spotted green pufferfish
XP_015201190 222 WYQL 225 spotted gar
NP_919353    180 WYVQ 183 zebrafish
XP_011480690 184 WYVR 187 Japanese medaka
PNJ06179     171 WYVR 174 Sumatran orangutan
1_pfamImport 159 WYVR 162
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