Conserved Protein Domain Family
HNF-1A_C

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pfam04813: HNF-1A_C 
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C-terminus
This family consists of an alternative C-terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Statistics
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PSSM-Id: 398469
Aligned: 5 rows
Threshold Bit Score: 64.3677
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006151581 542 VFTSDPEAAGESGLHTpasqaTTLHVPNQDS-----AGIQHLQPTHRL-SASPTVSSSSLVLYQSSDSTNG--H-SHLLP 612 Chinese tree shrew
3_pfamImport   1 ILTTDPDEQEDAPLQE-----DSLNMQPHSP-----APAQHRQKLHVTdTIKLTVSSESLELYPSSQATES--HqSHLLS 68 
2_pfamImport   1 VFSSDSEAPSESGLHTpvsqaSAIHIPSQDPeagerAGAQGSRSSPA--TLASAVSSSSLVLYQGSDSTSS--H-SQLLS 75 
NP_001025839 546 aFTSDSETHTDSGIHTpvsqaPAIHLQNQDT-----A-IQHLQSGPRL-TPSPAVSSSSLVLYQSSDSTNS--H-SQLLP 615 chicken
XP_027422355 569 VFTSDAEASSESGLHTpvsqtTTIHIPGQDP-----AGIQQLQPSHRL-SASPTVPSSSLVLYQSSDSTNGhsH---LLP 639 hybrid cattle
XP_006151581 613 SNHSVIETFISTQMASSS 630 Chinese tree shrew
3_pfamImport  69 PSPTEISSYIPAQMVSTA 86 
2_pfamImport  76 SNHGVIETFISTHMASSS 93 
NP_001025839 616 STHNVIETFISTQMASST 633 chicken
XP_027422355 640 SNHSVTETFISTQMASSS 657 hybrid cattle
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