Conserved Protein Domain Family
HNF-1B_C
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pfam04812: HNF-1B_C 
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C-terminus
This family consists of a region found within the alpha isoform and at the C-terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
Links
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Statistics
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PSSM-Id: 398468
Aligned: 10 rows
Threshold Bit Score: 294.594
Threshold Setting Gi: 47217575
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q90867       285 AMDNFSGPQPTSAP-PLTPHNSSSLqPPPALSPTKVH-GVRYNQQPASEAESSSS-NHHGNSS---MVTTQTILHQVSPP 358 chicken
P23899       314 AMDAYSSNQTHNLN-PLLTHGSPHH-QPSSSPPNKLS-GVRYSQPGNNEVTSSSTiSHHGNSA---MVTSQSVLQQVSPA 387 Norway rat
XP_014345048 286 AMDSYSNQQPNTVT-PVTPHNTSl--QHGALSPNKVQvGVRYGQQSTSDDMSPSV-SHHGNSA---MVTTQTILQQVSSP 358 coelacanth
XP_006151581 282 AMDTYSGPPPGPGPgPTLPAHSSPGlPPPALSPSKVH-GVRYGQPANSEAADVPS-SSGG--P---LVTVSAPLHQVSPT 354 Chinese tree shrew
XP_006640975 193 AMDAYSGAPSHGMN-SLLSHSSPHQpPASTSPPSKMQ-GVRYSQQGASEVTSSTTiSHHGNNV---MATSQSVLQQVSPG 267 spotted gar
XP_007248687 322 AMDAYSG-QTHSMN-SLLSHSSPHHpQASTSPPSKMQ-AVRYNQ-GPGEVSSSTTiSHHSGNG---MTSGQSVLQQISPG 394 Mexican tetra
XP_022615518 327 AMDAITA-PTHSIN-PLLSHSSPHHpQTSASPPm-------RYSQGPGEVTSSTTiSHHNSNA---MATSQSVLQQVSPG 394 greater amberjack
CAG02502     279 ALDAPFS-QPSSAN-HALPTSPEP--------------GVKYSPQMLCDGVTSARlAGGDRTG----------CLVVSPV 332 spotted green p...
XP_019661120 288 AMDAYSSNHTHNLN-PLLSHGSPHH-QPSASPPNKLS-GVRYSQPGNNEVTSASTiSHHGNSA---MVTSQSVLQQVSPA 361 giant panda
XP_016853691 339 AMDAYSTGQPHTMN-LLLSHNSPHHvQASASPPSKMT-GVRYGQAGPNDVPSSSSiGHHVNSTsamVTSSQAILQQVSPV 416 green anole

Q90867       359 GLEP--SQNLLSTDTKLISAPGGTLPPVSTLTALHSLeqnPHALGQQTQNLIMASLPGVMAIgagetsslaprftntggS 436 chicken
P23899       388 SLDP--GHSLLSPDSKMISVSGGGLPPVSTLTNIHSL---SHHNPQQSQNLIMTPLSGVMAI-----------------A 445 Norway rat
XP_014345048 359 GLEP--SQSLLTTDTKLISTSGGTLPPVSTLTALHSLhqnPHTVTQQTQNLIMASLPSVMAIgpgdtptltpslsntgpS 436 coelacanth
XP_006151581 355 GLEP--SHSLLSTEAKLVSTAGGPLPPVSTLTALHSLeqtSPGLNQQPQNLIMASLPGVMTIgpgepaslgptftntgaS 432 Chinese tree shrew
XP_006640975 268 GLDP--SHSLLSPDAKMISVSGGGLPPVSTLTNIHSLsqsSHHGHQQTQNLIMTPLSGVMAI-----------------T 328 spotted gar
XP_007248687 395 ALDP--SHSLLSPDAKMISGSGGGLPPVSTLTSMHg----PHHAHQQTQNLIM-PISGVMAI-----------------A 450 Mexican tetra
XP_022615518 395 GLDH--SHSLLSPDAKMISGSGGGLPPVSTLTNIHS----SHHSHQQtqNLIM-PLSGVMAI-----------------A 450 greater amberjack
CAG02502     333 QLEP--SHTLLDTQNPKQVSSGGPLPPVSTLTSLHSL----SASPASSPSLIMASLPSVMSLgesslliaevnkgrhsgS 406 spotted green p...
XP_019661120 362 SLDP--GHNLLSPDGKMISVSGGGLPPVSTLTNIHSL---SHHNPQQSQNLIMTPLSGVMAI-----------------A 419 giant panda
XP_016853691 417 GLDPghGHGLLAPDGKMITVSGGGLPPVSTLTNIHSF---SHHNPSQSQNLIMAPLSGVMAI-----------------T 476 green anole

Q90867       437 TlviGLTSTQPQSVPVINSMGSSLTTLQPVQFSQQLHPSYQQPLMQQVQ-SHINQSPFMATMAQIQNPHaLYGPKSEVAQ 515 chicken
P23899       446 Q---SLNTSQAQGVPVINSVASSLAALQPVQFSQQLHSPHQQPLMQQSPgSHMAQQPFMAAVTQLQNSH-MYAHKQEPPQ 521 Norway rat
XP_014345048 437 TfviGLTTSQAPNVPVINNMGSSFATLQPVQFPQQLHSPHQQPIMQQVQ-GHMAPNSFMATMAQLQNPH-VYSHKPELPP 514 coelacanth
XP_006151581 433 TlviGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQ-SHVAQSPFMATMAQLQSPHaLYSHKPEVAQ 511 Chinese tree shrew
XP_006640975 329 Q---SLNTSQAQSVPVINSVTGGLAALQPVQFPQQLHSPHQQSLMQQSP-SHMAQQPFMATVTQLQNSH-MYSHKQEPPQ 403 spotted gar
XP_007248687 451 Q---SLNTSQAQTVPVINSVAGSLATLQPVQFSQQLHSSHQQGLMQQSH-SHMSQQPFMATVT---HSH-MYSHKQEPPQ 522 Mexican tetra
XP_022615518 451 Q---SLNTSQSQTVPVINSVAGSLAALQPVQFSQQLHSPHQQSLMQQSP-SHMSQQPFMATVT---HSH-MYPHKQEPPQ 522 greater amberjack
CAG02502     407 GvvtGLASTQPQSVPVINNVGAGFTTLQPISFQQQLHASPQQPIPQHLQ-GHMGSSPFMATMAPLPCH--MY--KSDSPQ 481 spotted green p...
XP_019661120 420 Q---SLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPgSHMTQQPFMAAVTQLQNSH-MYTHKQEPPQ 495 giant panda
XP_016853691 477 Q---SLNSSQAQTVPVINTVASSLAALQPVQFSQQLHSPHQQSLMQQSP-SPMAQPPFMATVTQLQNSH-MYSHKQEPPQ 551 green anole

Q90867       516 YTHTGLLPQTMVITDTANLSALTNLT 541 chicken
P23899       522 YSHTSRFPSAMVVTDTSSINTLTSMS 547 Norway rat
XP_014345048 515 YTPSGLFSSTMVITDTGNLSAITGLA 540 coelacanth
XP_006151581 512 YTHTGLLPQTMLITDTTNLSALASLT 537 Chinese tree shrew
XP_006640975 404 YSHPSRYPSAMVVTDASSISTLASMP 429 spotted gar
XP_007248687 523 YSHPSRFPSAMVVTDTNSLSTLSSMS 548 Mexican tetra
XP_022615518 523 YSHPSRFPSAMVVTDANsistlssms 548 greater amberjack
CAG02502     482 YPSSSLLSQALVIADSSSLGTLTSLT 507 spotted green pufferfish
XP_019661120 496 YSHTSRFPSAMVVTDTNSISTLTNMS 521 giant panda
XP_016853691 552 YSHTSRFPSAMVVTDTSGITSLTNMS 577 green anole
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