3J3A


Conserved Protein Domain Family
HABP4_PAI-RBP1

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pfam04774: HABP4_PAI-RBP1 
Hyaluronan / mRNA binding family
This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo. It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.
Statistics
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PSSM-Id: 398441
Aligned: 75 rows
Threshold Bit Score: 55.0488
Threshold Setting Gi: 599348148
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3J3A_HH      189 GKREFDRHSGSDRssfshysglKHEDKRGGSGSHNWGTVKDELTESPKYIQKQI---SYNysDLDQSNvt-------eeT 258
XP_007390441 107 GRRPFDRHSATGK---------TDSEKKVHQG---WGGDEGTAELKAETAAE-------K--DAQAEAgnpia---egwg 162 Phanerochaete c...
XP_003435815 209 GKRELDRQSGSNKtg------iKAVDKRDGAGSHNWGSSKQDAKEYSNNPDQDFqpqDAD--TSae------------aN 268 Anopheles gambi...
Q16ZT8       183 GKREFDRQSGSNKtg------vKAVEKRDGTGSHNWGSAKLDAKEFNNFQEEY----MPhe-----------------aE 235 yellow fever mo...
AGO02039     175 GKREFDRRSGSDKtg------vKSVDKREGAGPHNWGTIKDDLDELNKTGSEge------------------------tT 224 domestic silkworm
EEB10309     246 GKREFDRKSGSDKtg------vKAMEKREGGGAHNWGNHKDDLEAVNLns----------------------------tN 291 human body louse
EFX80179     187 GKRDFDRQSGSDKsg------vKPIEKREGSGPHNWGSVQDEIEGQLEP-----------------AVaeevvegeaevV 243 common water flea
Q9V426       217 RKREFDRQSGSDRtg------vKSIDKRDGAGSHNWGSVKEAIDDVNKN------------------------------- 259 fruit fly
XP_015028203 210 RKREFDRQSGSDKtg------vKAIDKRDGAGAHNWGSVKEAIDDVNKSn-----------------------------e 254 Drosophila virilis
XP_011406826 228 GKREFERRSGSDKss------vKAFDKREGGGAHNWGTVKDDMNTNEWATDEQEaatDNN--ATELNEen--------tN 291 Amphimedon quee...
3J3A_HH      259 PEGEEHHPVADTENKEn----------------------eVeevkeegPKEMTLDEWKAIQNKDR-AKVEF-NIRKPNE 313
XP_007390441 163 AEASTDAWAAPAEGAEgaevvegttpaegekaegrrreeeE-------DNTLTLDEYFKQQKEKQlEIIPQlETRKANE 234 Phanerochaete ca...
XP_003435815 269 AERTNVSNGGEEAGADgaaag---------------rsddE-------AKEMTLDEWKAQKAAAR-LKPQY-NLRKAGE 323 Anopheles gambia...
Q16ZT8       236 EEKGQASDQTKEEQTEqsdak---------------pveeE-------LKEMTLDEWKAQIAAAR-SKPQY-NIRKAGE 290 yellow fever mos...
AGO02039     225 EEKAPEAGAGDGQVPEterav---------------paeeE-------PRELTLDEYKALRNAQR-TAPQY-NLRKAGE 279 domestic silkworm
EEB10309     292 ASEENAEWSEGKPGNNdvgennan--------gepvqveeE-------PKELTLDEYRA-LRGKR-ELPQY-NIRKAGE 352 human body louse
EFX80179     244 APAETAEVKEGEETAPvap------------------edeE-------PKELTLDEWRA-LRGER-KKPEF-NIRKPGE 294 common water flea
Q9V426       260 ESETNVTNAEGGAKADesgtepqn---------eqataeeE-------AKELTLDEWKA-QQGQR-IKPTF-NIRKAGE 319 fruit fly
XP_015028203 255 GGETNANNTNADGKADesgneqtn--------eqqtppeeE-------TKELTLDEWKA-QQQQR-IKPKF-NIRKAGE 315 Drosophila virilis
XP_011406826 292 DQSEVVEGEGETESKVapgseeke--------geeeeeekE-------TPQFTLDEYKAMQDKKR-TVPLH-KERRPGE 353 Amphimedon queen...
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