Conserved Protein Domain Family
MATalpha_HMGbox
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pfam04769: MATalpha_HMGbox 
Mating-type protein MAT alpha 1 HMG-box
This family includes Saccharomyces cerevisiae mating type protein alpha 1. Mat alpha 1 is a transcription activator which activates mating-type alpha-specific genes. MAT alpha 1 and MCM 1 bind cooperatively to PQ elements upstream of alpha-specific genes. Alpha 1 interacts in vivo with STE12, linking expression of alpha-specific genes to the alpha-pheromone (pfam04648) response pathway. In silico modelling of the MAT_Alpha1 domain indicates that its best scoring templates were structures of HMG-box proteins, and DOI: 10.4236/ojbiphy.2013.31001. Phylogenetic analysis suggests that the MAT_Alpha1 domain diverged from the MATA_HMG-box subfamily. The name of MATalpha_HMG-box was proposed for the MAT_alpha1 domain.
Links
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Statistics
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PSSM-Id: 398438
Aligned: 9 rows
Threshold Bit Score: 142.652
Threshold Setting Gi: 60390164
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EGU79451               34 PNRLAEALSSPHMLKEMLDLFGHEylpvfegeikphrPLGTSDSRAKRPLNAFMAFRTYY--LKLFPD-TQQKNASGFLT 110 Fusari...
XP_011319815           17 QERLNAAMENPSMMRELLEICGTElaac------igpSIGDPVQRAKRPLNGFMAFRTYY--LKLFPD-TQQKDASGFLT 87  Fusari...
WGS:AAGI:SNOT_00375.2  32 PIARNVLLAQLFNTKAAPSIAALA---------------TMPPRKLKKALNGFIGYRSWLkaIPFFNM-WPMKNISSYIG 95  Parast...
EMD90042               34 PAAQAAFTAKLLVVPPAVS------------------GRPATPEKARKALNAFVGFRCYYvtIPMFKS-WPMKKLSNLIG 94  Bipola...
Q08398                 57 TSIPAPPQVLVAYIKEKVKTLNKSevlmslgnsnqlsSRDVKTKTKKKQINDFIAFRSYY--SRLLNGiLTQTELSTIIS 134 Kluyve...
XP_003651348           17 GERETTMKALSTMMRA-----------------------ENQSQPAKKKVNGFMGYRAYY--SSLFSL-LTQKEKSPIMT 70  Thermo...
Q2H429                 17 GDRETTMKALSTMMRT-----------------------ENQRQPAKKKVNGFMGYRAYY--SSLFSQ-LAQKDKSPIMT 70  Chaeto...
O42837                 17 GERNAAVNAILAMMPPGPGPVRQIp------------EPVSQAPAPKKKVNGFMGFRSYY--SPLFSQ-FPQKARSPFMT 81  Sordar...
ESA43846               17 DDREAAMRAFSRMMRRGTEPVRRI-------------------PAAKKKVNGFMGFRSYY--SPLFSQ-LPQKERSPFMT 74  Neuros...

EGU79451              111 QLWGGD-PHRNKWALIAKVYSFLRDQLGK------GTVNLSAFLGIACPLMNMVEPSIYIEVLGWE-QTAPQGIVTFQQn 182 Fusari...
XP_011319815           88 QLWATD-PNRNKWALIAKVYSFTRDHVGK------AKCNLNPFLSVACPMMKIVEPSEYFGLFGWQvSHDSFGNMVLVQd 160 Fusari...
WGS:AAGI:SNOT_00375.2  96 QLWEHE-PDKPLWTLMTKAWSAIRDQVGK------DMAPLDKFLDIVCTELKVLPPTLYLQGRGWKiEYNSEGAPTLLHd 168 Parast...
EMD90042               95 LLWEAD-PNKSLWSLMAKAWSTIRDQIGK------DQAPLDQFFRIICPHLKLPDPASYLEIHGWIlTVNEEGDPTISRs 167 Bipola...
Q08398                135 KHWTVDkQTRKNWELIAQEYNC--DASGK-------------------------------HFFNWLeVNYGIDKQWLYE- 180 Kluyve...
XP_003651348           71 TLWKQD-PFHKEWDFMCAVYSAIREFLSD------EEVSLQDWIQFAVKHLGIVVRENYLETLGWElVKLEDGTHKVQR- 142 Thermo...
Q2H429                 71 MLWRED-PFHKEWDFMCAVYSVIREFLSD------ENITLQNWIQFAIKHMGIVIRESYLAALGWKlIRLDDGTHKVER- 142 Chaeto...
O42837                 82 ILWQHD-PFHNEWDFMCSVYSSIRNYLEQsnaqreKKITLQYWLHFAVPVMGVLGRENYLPTLGWDlVTMPNGTIDLMR- 159 Sordar...
ESA43846               75 ILWQHD-PFHNEWDFMCSVYSSIRTYLEQ------EKVTLQLWIHYAVGHLGVIIRDNYMASFGWNlVRFPNGTHDLER- 146 Neuros...

EGU79451              183 tdimkANLARLFNV-HPTTEIDLLTSILSAGY----FTDFSQVLLMRMWACQNGIMT 234 Fusarium oxysporum Fo5176
XP_011319815          161 lavmaNTMPPLENLeHPTTEIDLLTDILVAGY----FSEYSQHLQVLMWTSQNGIMA 213 Fusarium graminearum PH-1
WGS:AAGI:SNOT_00375.2 169 ptsssAAALGYGFKgQTLSVSDIIEICQKRGYatsyAPNKNDACPTFLGQnpqalrl 225 Parastagonospora nodorum SN15
EMD90042              168 adsefVSI-GTGNTdVALSVEDIITYVQSLGYahgfILDDNKPSSTFLGQSVSstle 223 Bipolaris maydis C5
Q08398                181 ------------------------------------IVQYEECLtpttkkpyveniy 201 Kluyveromyces lactis NRRL Y-1140
XP_003651348          143 -----TATRVVQGYsQPMNGLGLFMNCLNDGL----PVSNPLPIIAKLSALTNDIIC 190 Thermothielavioides terrestri...
Q2H429                143 -----TEVRAVQSYlQPMNGLGLFINCLNGGL----PVANPLPIIAKLTDLTNDVIC 190 Chaetomium globosum CBS 148.51
O42837                160 -----IAMPLFRKNlQPMNGLCLFTKCQEGGL----QVDNQHLVIAKLSDPSYDMIW 207 Sordaria macrospora k-hell
ESA43846              147 -----TALPLVQHNlQPMNGLCLLTKCLESGL----PLANPHSVIAKLSDPSYDMIW 194 Neurospora crassa OR74A
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