5HWK


Conserved Protein Domain Family
ChaC

?
pfam04752: ChaC 
Click on image for an interactive view with Cn3D
ChaC-like protein
The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.
Statistics
?
PSSM-Id: 398428
Aligned: 9 rows
Threshold Bit Score: 234.207
Threshold Setting Gi: 81535064
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5HWK_B   8 IWVLGYGSLIYKPPSHYTHRIPAIIHGFARRFWQSSTDHRGTPANPGRVATLIPYEDiirqtaflknvnlysesapiqdp 87  Saccharomyces cerevis...
Q9CQG1   1 MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVPGKPGRVVTLVEDPG----------------------- 57  house mouse
Q9VCI9  57 CWVFGYGSLCWHPGFNYTKCITGYIRGYVRRFWQGNVTHRGCEEKPGRVATLVEDKE----------------------- 113 fruit fly
Q8R3J5  34 LWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDRE----------------------- 90  house mouse
Q9GZE8  50 LWIFGYGSLIWNPGFTFSTSRKAYAIGWARRMYQGNTYHRGDEKLPGRVATLIEETN----------------------- 106 Caenorhabditis elegans
P87305  10 LWVFGYGSLIWHPPPHYDYSIPCFIKGYVRRFWMRSEDHRGTVNSPGLVLTLIPYEEwkqfsdw------------sftp 77  Schizosaccharomyces p...
Q9A674  10 RWVFGYGSLMWRPGFPFIDRRTAVLHGRRRAFCIYSVHHRGTYERPGLVLGLAPG------------------------- 64  Caulobacter vibrioides
P39163  47 VWIFGYGSLMWNPALEFTESCTGTLVGWHRAFCLRLTAGRGTAHQPGRMLALKEG------------------------- 101 Escherichia coli K-12
Q9VYK7  74 VWIFGYGSLVWKTDFPYIDRRRGFVWGFKRRFYQHSIDHRGIPERPGRVVTLLPgdp----------------------- 130 fruit fly
5HWK_B  88 ddLVTIGVVYYIPPEHA-QEVREYLNVREQ--NGYTLHEVEVHLetnreheaelgealeqlpRHNKSGKRvlLTSVYIGT 164 Saccharomyces cerevis...
Q9CQG1  58 --GSVWGVAYKLPVGKE-EEVKTYLDFREK--GGYRTTTVIFYP------------------KDSTTKPF--SVLLYIGT 112 house mouse
Q9VCI9 114 --GITWGCAYRITGST----ALDYLKQRECtlGGYATIDTKFFPrv--------------asQDTPFSGEavEVLVYVAT 173 fruit fly
Q8R3J5  91 --GCTWGVAYQVRGEQV-NEALKYLNVREAvlGGYDTKEVTFYP------------------QDTPDQPL--TALAYVAT 147 house mouse
Q9GZE8 107 --SYTNGVVFRVDGKSAiATAVKYLEQRECd-NGYAFRMVPVQIr-----------------SAAHRRPTvvMALTCVAD 166 Caenorhabditis elegans
P87305  78 fdEGCWGMAFRIPAKYA-TQVREYLDDREv--NGYTAHSVPVYA------------------HTGDEIPVleNCLVYVGT 136 Schizosaccharomyces p...
Q9A674  65 --GSVRGMAYRVAAAEW-EGVYAYLREREQptEtyfet-------------------wrevkVD-GGDKA--PALVFLSD 119 Caulobacter vibrioides
P39163 102 --GRTTGVAYRLPEETL-EQELTLLWKREMitGcylpt-------------------wcqldLD-DGRTV--NAIVFIMD 156 Escherichia coli K-12
Q9VYK7 131 aqDRVYGVAYRIAASQK-GAVLDHLDYREK--NGYERCSLEFHEy-----------------PTDGAEPI--QVIMYVAT 188 fruit fly
5HWK_B 165 IDNEAFVGPE-TVDETAKVIAVSHGPSGSNYEYLAKLEQALAQMPImkerGrITDHYLTALLETVNKY 231 Saccharomyces cerevisiae S288C
Q9CQG1 113 CDNPNYLGPA-PLEDIAEQIFNAAGPSGRNTEYLFELADSVRKLVP----E-DADEHLFSLEKLVKER 174 house mouse
Q9VCI9 174 PENIYWLGDD-PVEEIAQQIVSCRGPSGHNAEYLLRLALFMHEEIP----G-VRDDHLFELEQLVLEE 235 fruit fly
Q8R3J5 148 PQNPGYLGPA-PEEVIATQILACRGFSGHNLEYLLRLADFMQLCG-----PqAQDEHLEAIVDAVGTL 209 house mouse
Q9GZE8 167 qQNELYLGPD-DLIKMAREIVTAKGCAGPNCEYVLNLAENLRKLFP----N-DEDDHLFQLEHHVRIA 228 Caenorhabditis elegans
P87305 137 sKSPQFQPSD-DLTQMAKIISTRRGKSGDNFVYLFELAKCLRHLSP----E-SKDIHVFELEAEVRKQ 198 Schizosaccharomyces pombe 972h-
Q9A674 120 MKHSQWAGDL-TLEQQAALIAGAVGLSGPNIDYLRDLVMHLHEDG-------VRDHAMEKLLKMVEAR 179 Caulobacter vibrioides
P39163 157 PRHPEYESDT-RAQVIAPLIAAASGPLGTNAQYLFSLEQELIKLG-------MQDDGLNDLLVSVKKL 216 Escherichia coli K-12
Q9VYK7 189 QANDSYAGDVwQVPCIARQIFSSAGPSGPNREYLFNLAAAMDQL-Fp---G-AVDEHLEELVACVKRY 251 fruit fly
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap