Conserved Protein Domain Family
Caudal_act

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pfam04731: Caudal_act 
Caudal like protein activation region
This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).
Statistics
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PSSM-Id: 398418
Aligned: 27 rows
Threshold Bit Score: 67.4798
Threshold Setting Gi: 655651687
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q90X89        13 MYPNP---VRHP-GLNLNPQNYVp-APP----QYSDFPSY---HHVPGIns-dPHHGQ-PGGTWSS-YTPS---REDWHP 74  tropical clawed...
XP_005988338  13 MYPNS---VRHP-SLNLNPQNFVp-APP----QYSDFAGY---HHVPGInt-dPHHGQ-PTGTWGSpYAPT---REDWHS 75  coelacanth
XP_003764520  13 MYPSS---VRHSgGLNLAPQNFV--SPP----QYPDYGGY----HVAAAnldsAQS---PGPSWPSpYGAPl--REDWNG 74  Tasmanian devil
XP_005993018  13 MYPSS----RHS-GLNLGAQNFV--NPP----QYPDYGGY---HHVPGVnldnPPQ---CSGSWPSpYGPP---REEWGA 72  coelacanth
XP_015205159  13 MYSNS---VRHP-SLNLNPQNFVp-PPP----QYSDFAGY---HHVSGInn-dPHHGQ-TTGTWSPaYAPA---REDWPT 75  spotted gar
AAW83121      13 MYPNS---VRHP-SLNLNPQNFVp-APP----QYPDFTGY---HHVPGIttndPHHSQ--TGSWNPaYPPP---REEWTP 75  zebrafish
XP_003459584  14 MYPHQnpvTRHP-GLSLSPQNFSvpAPP----QYPDFASYhhhHHGIGNeqhpAQQAPpAAGGWSPaYPPPppaRDDWSS 88  Nile tilapia
XP_001369246  13 MYPNP---VRHP-GLNLSPQSYMpsAPPt---QYSDFPGY---QHVQGIns-dPPHGQ-AGGAWSSpYPPA---KDDWTS 77  gray short-tail...
XP_008253476  13 VYPGP---ARPA-SLGLGPQAYGppGPPpaapQYPDFTGY---SHVEPA--------PaAATAWGApFPAP---KDDWAA 74  rabbit
XP_030132115  13 MYPGP---VRHSgGLNLAAQNFV--GAP----QYADYGGY----HVnl---dgAQS---PGPAWPApYAAPl--RDDWGT 71  zebra finch
Q90X89        75 YG--PGPGASS---------ANP-AQISFS-PSDY-------NPVQP----PGP--GL-LPPSLNSSV-------SPLSP 120 tropical clawed...
XP_005988338  76 YG--PGPASTS---------TNP-GQIAFS-PPDF-------NPVQP----PGP--GL-LPPTINSPV-------SQLSP 121 coelacanth
XP_003764520  75 YA--PGATATAnsvahglngGSPaAAMGYSsPADYhsh--hhPHHHPhhpgTAPscASgLLQTLNSGPpva-taaEQLSP 149 Tasmanian devil
XP_005993018  73 YA--TGPANIHpl------nTSP-GTISYS-PAEY-------N--------PAQtlGSgVIQTLNSNSv------EQISL 121 coelacanth
XP_015205159  76 YA--PGTGPST---------SNP-GQITFS-PPDY-------NPVQP----PGP--GI-LPSPLNSSV-------GQLSP 121 spotted gar
AAW83121      76 YG--PGSGVSS---------SST-GQLGFS-PPEF-------SSVQT----PGL-----LQSSINSSV-------GQLSP 119 zebrafish
XP_003459584  89 HPyaPPAASSVt-------gAVG-TTLGFG-PTEF----------------PGQppAL-IPASLNASA-------GPLSP 135 Nile tilapia
XP_001369246  78 YG--PGPTAPT---------ASP-AQIGYS-PADF-------GAIQAp---PGAglGL-LPSSLSTPG-------APLSP 126 gray short-tail...
XP_008253476  75 YG--PGPAAPA---------ASS-AQLAFGpPPDF-------SSVPAp---PGPgpGL-LAQPLGGPG-------APSSP 124 rabbit
XP_030132115  72 YGqgAPPAAGAvhg---lngGSPaAPMAYS-PADYhhhhhhpHA--HhhagPAPhcSAgVMQPLNAASaaasaapEPLSP 145 zebra finch
Q90X89       121 S-AQRRNLYEWMRR 133 tropical clawed frog
XP_005988338 122 T-AQRRNPYDWMRR 134 coelacanth
XP_003764520 150 G-GQRRNLCEWMRK 162 Tasmanian devil
XP_005993018 122 N-SQRRNPYDWMKK 134 coelacanth
XP_015205159 122 TsSQRRNPYEWMRR 135 spotted gar
AAW83121     120 N-AQRRNPYDWMRR 132 zebrafish
XP_003459584 136 GsPRRRTPYEWIRT 149 Nile tilapia
XP_001369246 127 S-TQRRTPYEWMRR 139 gray short-tailed opossum
XP_008253476 125 G-TQRRTPYEWMRR 137 rabbit
XP_030132115 146 G-GQRRGLCEWMRK 158 zebra finch
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