2G9F


Conserved Protein Domain Family
PAW

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pfam04721: PAW 
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PNGase C-terminal domain, mannose-binding module PAW
The PAW domain is found at the C-terminus of PGNase, or peptide-N-glycanase, enzymes. It was named for 'domain present in PNGases and other worm proteins'. PNGase catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving off the bulky glycan chain before these proteins are degraded by the proteasome. PNGase specifically acts on the unfolded form of high-mannose type N-glycosylated proteins, and this domain appears to be the mannose-binding domain, which contributes to the oligosaccharide-binding specificity of PNGase.
Statistics
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PSSM-Id: 398412
Aligned: 38 rows
Threshold Bit Score: 189.016
Threshold Setting Gi: 341875900
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2G9F_A         4 GRVSGSLAWRVARGETGL---------ERKEILFipsE--NEKISKQFhlRYDIVRDRYIRVSDNN----TNISGWENGV 68  house mouse
XP_011137990 421 GRTSGSLVWRLARGELMSadkdylnkcMYKDYIW---D--VSKYGQIFelRYNIIKDIYQIVHNDGtf-lEQIHKWSEGI 494 Jerdon's jumpin...
XP_015785923 321 GRSSGSIDWRVARGECSStq------tKIKNFIIkfnD--NTKDGK-YrfTYHSVSDKYFINDFQL-------NGWESAV 384 two-spotted spi...
1_pfamImport   1 ---SGSEEWRLARGEMGSn-------aAPETPLGapiK--LTQSADHLefSYNIVTDTYSQEPA---------KGFVSAT 59 
EGT31835     406 GRTTGSEQWRRARGELGSvap----klDAPKLFGkpiNl-IANSENYAefSYDIIRNIYSTSTE---------KGFISQA 471 Caenorhabditis ...
XP_016839977 440 GRTSGSLAWRISRNETGDt-------------sFtatQwnIPRDVLNFelTYSILNDTYVTKDTSNsknlETRQKWQTGV 506 jewel wasp
XP_011052918 418 GRTSGSLMWRLARGEIMQa-------dTEKSYIW---D--ISKYGETFelRYNIVKDLYYVVRNNGti-lEEKSGWLEGM 484 Panamanian leaf...
XP_011264466 414 GRTSGSLVWRLARGETEQa-------nIEKNYIW---D--VSKYEQTFelQYNIVKDIYHIVHNDGti-lEQKSGWQEGI 480 Florida carpent...
5_pfamImport   1 GRTSGSLTWRTARGETEGekr---ktlVENFKAIkstD--VELKNGKIhiEYSCSSDKYTRISDSK----TSHGGWKTFV 71 
XP_002122689 401 GRTSGSLAWRLARGETDKvkdg--kskMETCEVIrpsE--DEIKSGMLtlEYSSSLDKYTRITDNN----KSYDGWKSLV 472 vase tunicate
2G9F_A        69 WKME-SIFRKVEKDWNMVYLARKEGSSF---AYISWKFECGs-AGLKVDTVSIRTSSQSFESGSVRWKLRS----ETAq- 138 house mouse
XP_011137990 495 NSTCgGMFRKTEEDWKMVYLARSEGTSN---GHVTWAFKVAn-PQLCIETFNLKAKSQVFHGASVSWEIEAifndNKT-- 568 Jerdon's jumpin...
XP_015785923 385 FNFD-NIFKKVEKDWNMIYLSRQENSDCskkGTLTYKFDVR----FNWTAMIIKINTKVYDTGRVSILLTS-----EPef 454 two-spotted spi...
1_pfamImport  60 FECE-NIKRVEENDWKFVYLCRKDGAKE---GNISWHFDLE--------SI-----GKPLEK--VEVRVAGiekfEKAk- 119
EGT31835     472 FECK-NIQRKEELDWKQVYLCRENGKES---GEISWHINLE--------SLTAN-STKSIEK--VEIQMMGirkwEKAn- 535 Caenorhabditis ...
XP_016839977 507 AFVEgGIFTKKEEDWKMIYLAKSPGSIV---GKITWAFVVEdnENMYINSVKLQAKTATFHGGSVKWQVEGiysnENTkg 583 jewel wasp
XP_011052918 485 NTMEgGVFRKVENDWKMVYLTRSQQAKH---GSVKWTFEIPn-SKSCLETLTLKAKSKVFQNAMVSWEIEAifdnDRA-- 558 Panamanian leaf...
XP_011264466 481 NTTDgGIFRKVEDDWKMVYLARSPDAQC---GRIKWTFKIAn-SKLYLETFNLKAKSEVFHEASVSWKIEAvfsdDKV-- 554 Florida carpent...
5_pfamImport  72 FRVQ-DVMRKVEYDWKRAYLCRKEKSLM---GYIAWQIELP--KTYAISVAEIFVADTIFEDGFVKWLVTT----DKTs- 140
XP_002122689 473 YCHQ-DVMKKVEQDWKQTYICRKEDTSV---GYISWRVELP--NTCLLTHVELCVKDSVFEQGHVSWLLTT----DKTt- 541 vase tunicate
2G9F_A       139 --VNLLGdknlrs-yndfsGA-T-------EVTLEAELSRGDGDVAWQHTQLFRQSLn--DS-GENGLEIIITF 198 house mouse
XP_011137990 569 --VTIPItqctsfhtkkveKA-M-------RLNLHVILSGGKDESAWQHAQLFRQSLe--DT-EEPSMIITIQL 629 Jerdon's jumping ant
XP_015785923 455 lnKEIDPdsvnglkksclkKDvD-------YIIMTMTLSGGSGNIGWQQAQLFRQSTl--AAaTDYSLDVIFtk 519 two-spotted spider mite
1_pfamImport 120 -aMVMAClgdtcmkissktGLlTidnptagILKISAALFGGEGSIAWQQAQIFRTKLd--EK-NGESLQIKV-- 187
EGT31835     536 -aMVIAClgdtcmkipangNL-TidepstgILKITANLIGGEGDQAFQHAQIFRTESdtdDE-RTNSLLVKiwl 606 Caenorhabditis brenneri
XP_016839977 584 esKVVSIlesenfetkdlkGA-I-------KINVTAVLSGGEGESAWQHAQLFRQSLd--ATsNDLSMVIRIdl 647 jewel wasp
XP_011052918 559 --VTISVpncsnfhteevrKA-V-------RINVIVTLSGGQGQEAWQHAQLFRQSLd--NT-EEPSMIINIQL 619 Panamanian leafcutter...
XP_011264466 555 --IAIPIsncnnfyteeiqKA-V-------KLDIIVTLSGGQGQLAWQHAQLFRQSLe--NI-EEPSMIVSIRL 615 Florida carpenter ant
5_pfamImport 141 --RSIKSgsseklellntkSR---------VLSIHAFLRGEN----WQHSQIFREATg--SP-SSPSLKLQIEF 196
XP_002122689 542 --HIVKSgtteki-dltksKS-Q-------FFSIHAFLRGEN----WQHAQLFREPLn--T--SEISFNVKVLw 596 vase tunicate
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