Conserved Protein Domain Family
PDDEXK_6

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pfam04720: PDDEXK_6 
PDDEXK-like family of unknown function
PDDEXK_6 is a family of plant proteins that are distant homologs of the PD-(D/E)XK nuclease superfamily. The core structure is retained, as alpha-beta-beta-beta-alpha-beta. It retains the characteristic PDDEXK motifs II and III in modified forms - xDxxx motif located in the second core beta-strand, where x is any hydrophobic residue, and a D/E)X(D/N/S/C/G) pattern. The missing positively charged residue in motif III is possibly replaced by a conserved arginine in motif IV located in the proceeding alpha-helix. The family is not in general fused with any other domains, so its function cannot be predicted.
Statistics
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PSSM-Id: 398411
Aligned: 89 rows
Threshold Bit Score: 130.782
Threshold Setting Gi: 1002225652
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003529329  31 VEFEFL--DDGeimsLAKsEGSgdefhqsneMELDDEDDGervDGGSVEENRS-----FWDNQHQLLQTN--------LY 95  soybean
XP_015616684  46 LVNEYLleAADdatvPSA---------------AVLAVGGgsdAEEDDEHE-------GGVGAAEEVDEIarvldaagGG 103 Japanese rice
1_pfamImport   3 LVNEYLl-EADdatvPSA---------------AVLAAGGsseVEDDEDDLDD-----DSAAAAEEVGEIrrv--leaAG 59 
BAS80642      52 LVHEFY--DDGergaDATa--------------R----------GGVSSSPEP-----EPTEWKDALREAl------aDA 94  Japanese rice
O48807        41 LVASFI--EKEgqivLRE--------------------------EEETSSDDN-----NLEDVNERLRKLl------eGL 81  thale cress
CDY53353      45 LIESFI--DREvkvlSGEvPPG---------EEN----------DDKSDADDD-----DDEDVKERLREIl------eNH 92  rape
XP_004250255  45 LVNSFL--EGEvitvNEKlEEIdgn---vetNCF------------------------DESEIKENLRNLld----pdGN 91  tomato
EEF43787      42 LVNSFI--ERDdhptILFmESD---------IKI----------NHPPDDDNQehysvSDAENKNILESLl------nKE 94  castor bean
XP_006586767  67 LVKSFM--EKNetttTGEkEEEeee----ggGVH----------EEELEKTEW-----SDSEKREMLQSFlygkedetDE 125 soybean
KRH11519      43 LVKSFM--EKNeattGEKeEEEvgd---vreGHD----------EEEFEKTEW-----SYSEKREMLRSLlye--nddDE 100 soybean
XP_003529329  96 RTTSVESRIRNVTKEAVQDiQnAEivcscsrqiisRscrNCFMiQVSRRLQKSGYDSAICKTKWSSSPSIPSGEHTFLDV 175 soybean
XP_015616684 104 DGDDLRRRIFADVVDSMRE-LeNV-----------RaqrSAFRrAVMSLLRERGHDAGLCKARWNKTSSMVAGSYEYIDV 171 Japanese rice
1_pfamImport  60 TGDDRRRRIFADVADAMRE-LeNV-----------RgerSAFRrAVMSLLRERGHDAGLCKARWDKTTSMVAGSYEYIDV 127
BAS80642      95 TSDAAAARIRAEAERAVRD-AvRNg-------------gDVIRkRVVERLRARGFDAGVCRSSWERTGSVPAGSHEYVDV 160 Japanese rice
O48807        82 SCGEERMRILSATMEVAGT-FvGDi--------------SSSKrHLMAFLRNKGFDAGLCKSSWERFGKNTGGKYEYVDV 146 thale cress
CDY53353      93 GGGGERRRIIDEVVNASEL-VgE-------------------KrYLMAYLRKKGFDAGLCKSRWERFGKNTAGKYEYVDV 152 rape
XP_004250255  92 SGDDLKKNVINAVENALLAe---------------EassPEFKrWLMTRLRDQGFDAGLCKLKWEKAVNRTSGSYEYIDV 156 tomato
EEF43787      95 DDDDVRKKIRSETEIACGI-IgERs-------------sHGFHrSLMSHLRHLGFDAGLCKSRWEKFGRYPAGEYQYVDV 160 castor bean
XP_006586767 126 DERDAKEKIRREVEVAFGL-VgNN-----------------YKrRLISLLREKGFDAGLCKSKWEKNGRLTAGDYEYIDV 187 soybean
KRH11519     101 DERDDKEKIRREAEVAFGV-VvGN----------------YSKrRLMSLLREKGFDAGLCKSKWEKNGRLTAGDYEYIDV 163 soybean
XP_003529329 176 IDsrs---kkqEiRVIIELNFRAEFEMARASEEYNGLVRKLPEVYVGKIERLSNIIKVLCMGAKRCMKENKMHMGPWRKH 252 soybean
XP_015616684 172 VVaaapdaaeaT-RYIVDVGFAGEFEVARPTEDYEAVRSALPEVLVARPDDVRKVVRAAASAARRSLKRRRLSVPPWRKR 250 Japanese rice
1_pfamImport 128 VVtaaga--eaatRYIVDVGFADEFDVARPTESYVAVRSALPEVLVARPDDVRQIVRAASSSLRRSLKHRRLSVPPWRKR 205
BAS80642     161 TAaasat--grraRYIVEVNVAGEFEIARPSAEYQDLLLSLPPVLVATPEAFRGVAAAMCAAAAESIRGAGMHLPPWRRA 238 Japanese rice
O48807       147 RCggd-----ynnRYFVETNLAGEFEIARPTKRYLSILSQVPRVFVGTSEELKLLVRIMCHEMRRSMKHVGIHVPPWRRN 221 thale cress
CDY53353     153 NEgd-------knRFIVETNLAGEFEIARPTTRYISLLSQLPRVFVGTPEELKQLVRIMSFEVRRSMKRAEIHVPPWRRN 225 rape
XP_004250255 157 NIgv--------tRYIIEVSLVEEFEIARATPCYTSLLENFPHVFVGKVEELKQVVRIMSRAMKRSMKKMNIYVAPWRRL 228 tomato
EEF43787     161 NVgg--------nRLIVEVCLAAEFEIARPTLNYTALVDDFPPVFIGKPEEMKQVVRLMCSAIRESMKEMKLHVPPWRKI 232 castor bean
XP_006586767 188 NFkg--------kRYIVEISLAGEFEIARPTDQYSSLLDVFPLIFVGKVEEMKQVVRLMCTAIKGSMKRMKLHIPPWRRN 259 soybean
KRH11519     164 NFkg--------kRYIVEVSLAGKFEIARPTDQYSSLLDVFPLIFVGKVEEMKQVARLMCTALKGSMKRMNLHIPPWRRN 235 soybean
XP_003529329 253 KYVHAKWLGPCKR 265 soybean
XP_015616684 251 KFMIAKWLGPYRR 263 Japanese rice
1_pfamImport 206 KFMLAKWLGPYRR 218
BAS80642     239 RYVQAKWSAPYER 251 Japanese rice
O48807       222 GYMQAKWFGFYKR 234 thale cress
CDY53353     226 GYMQAKWFGHYKR 238 rape
XP_004250255 229 AYMEAKWFGSYKR 241 tomato
EEF43787     233 GYMQAKWFAPYKR 245 castor bean
XP_006586767 260 VYMQAKWFGAYKR 272 soybean
KRH11519     236 MYMQAKWFSAYKR 248 soybean
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