Conserved Protein Domain Family
AMH_N

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pfam04709: AMH_N 
Anti-Mullerian hormone, N terminal region
Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C-terminus.
Statistics
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PSSM-Id: 398401
Aligned: 18 rows
Threshold Bit Score: 280.528
Threshold Setting Gi: 108948288
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005060059 125 SHYESSFIKLLrRRRSWDGTFPGTFGLCPaRGAGAAPHPLQRIHEHVLEP-GLQRFLVLH------LEEVQWEAQVKLRF 197 Collared flycat...
XP_007489460 136 SAYERGFVEAL-RQARWDRQGLATFGICPpGGPGGAHLSLQRLGAWLVEP-GGWSLVVLH------LEEVTWEPELSLWF 207 gray short-tail...
XP_007658143 174 SSYESGFLEEV-RQAQWGLRAQATFGICPpGETGVVF-SLQQLGAWLVEP-GGHHLMVLH------LEEVMWRQEPELRF 244 platypus
XP_009294509  74 QKTLNEFLSALkSAGELGKMDFV--GTCSpETQSSQVSHLVQSVLQK-----QSGLKGVHat--edIWDADNEGGITLTL 144 zebrafish
1_pfamImport   1 DDTYAALREAAgGDGELANRSRSQFGICGvSDGSAGSALLQLAKETGGDP--GRGLEVLHptgavlVSEEDERGALVLTF 78 
XP_013130583  56 EDIFAALRDGVgDSGELTNSSLVLFGFCSqSARSSASVSLDLANK-------KSSLEVLHpaa-vhVSEEEEQGTITLTF 127 Nile tilapia
ABG24272      35 DDAVAALREALqTDGALSNSSLTLFGACRaPDPSSRSTLLVLSEERRRWP--DGGLKVRQpa---aVFATEERGVVTLTF 109 Japanese medaka
XP_029684643  47 DDILAALRGSLgEGGELANQSLTRFGICAdPGDPTE-PLLEFVKETS----ERNQLQILHpta-apVSEDAESGSLRLTF 120 torafugu
CCP19123     146 TGYESSFVEDLqGASSPEGIVGDKFGICPgSHTHPVLLALRRMVSQLADSkERSKLIVLH------LDEVKWEEGIKLRF 219 Menado coelacanth
XP_023620423  86 RGYEQAFLEAV-QQAHWGPRDLATFGVCTpSHEHAALPLLQWLRVWLGEP-RGQRLVVLH------LEEVTWEPTPSLRF 157 little brown bat
XP_005060059 198 QL-----VFQAEVgralgeLQAAVMLFYLGRre--ssGPp------rELLLTGPGL-ARDQ-------RLCLSRDTQFLA 256 Collared flycat...
XP_007489460 208 QEppsllRGAGAP-------ELALLVLYPGP------GTggvqpgqqQFWVTGAGL-PPQQ-------SLCLSLDTRYLV 266 gray short-tail...
XP_007658143 245 QEp----RGAGSPdlllgsLDLALLVFYPGQ------GRe------qELTVSGDGL-QHEQ-------NLCLSQNTRYLV 300 platypus
XP_009294509 145 TFpkhslPAGPAS---------VMLLFSVNPvkg----------dslRVQFNSQSIhPNTQ-------TVCISESTRFLI 198 zebrafish
1_pfamImport  79 DLppsplLRRRPA----------LLLALEGPptg----------gnlDVTCTSRSLqPHAQ-------TACISGETWYIT 131
XP_013130583 128 DLprppsLMTNPV----------LLLVFENPlar----------gdlEVAFTSQFLqPNTQ-------AVCISGDTQYVL 180 Nile tilapia
ABG24272     110 DLpa-ssLLEMNL--------LLLLLAFESPaaa----------gdlEVTFSSRFLlPHSQ-------SACISEGTLYVL 163 Japanese medaka
XP_029684643 121 DLp---pSASPAL-------TPLLLLAFESRpaa----------gnlRVTFSSRSLqPDKQ-------TACVSAETLYVI 173 torafugu
CCP19123     220 KL-----AFRVDLeellkdLQVPLLVFYLGKvenasvGTeg-----aINIVGGGGL-HQNQ-------TICLSEFTRYMI 281 Menado coelacanth
XP_023620423 158 QEp---pSGEISP------SEMALLVLYPGS------GP--------EVTVTGAGL-LGTQaelpspqSLCLSRDTGYLT 213 little brown bat
XP_005060059 257 LAAAAASVTRSAer--lrFSASLAI-HGGArGAPLPRTEVQQLLFGSDDKCFTRMTPVLLLLAktrqqeeeeeeeeaLAP 333 Collared flycat...
XP_007489460 267 LAVDRTAGG---------DGLSLALrPQGGsGPSLATPELQALLFGLDHKCYTRMTPVLLLLQghs--------lgaKPK 329 gray short-tail...
XP_007658143 301 LGMEGTTGAWLPr-----LRLSLAFwPRGGhGS-LSPLELQPLLFGPDDKCFTRMTPVLLLLRqr----------grRGE 364 platypus
XP_009294509 199 V-----TGGWSHghihlkLKTMVETsMDDN-RPKLSVSELKEVLMRKVDSSSTMIKPVLLFLSdlee------------- 259 zebrafish
1_pfamImport 132 L-----TGKASEddvpqkWRISVEA------KSPDMNRSLKEILTGGRSGSNISVVP-LLLFSgkrg------------- 186
XP_013130583 181 L-----TGKSSEgsvndrWQITAQT------KLPHMKQNLKSILIGEKSGSNISMSP-LLLFSggtg------------- 235 Nile tilapia
ABG24272     164 L-----MGRSSSsssqhrWTISAEA------KSPRMNQNLIDAIIGGKPGGPVGVTP-LLLFTgeeg------------- 218 Japanese medaka
XP_029684643 174 L-----SGKTSNad--rtWRISAEA-------APDMKQRLKELLIGGKPGSVLNAVP-LLLFSgetg------------- 225 torafugu
CCP19123     282 FNTEGIVGAYFDgq--lsFEISLEFrYQAD-GTLLVQSELQQLLFGTDEKCFTRMTPVLFLLTkrar------erenDQH 352 Menado coelacanth
XP_023620423 214 LAVDHPAGAWHG------LGLALTLrHREN-GTPLSTAQLQALLFGADPRCFTRMTPALLLLL--------------RPG 272 little brown bat
XP_005060059 334 SSYLSAEGVVDTAPYPQLSPAqagse--elptpTAPSHantsSPAPGGSaqFLAVLTQFIRQLLNSSSEPPpqpSAHH-- 409 Collared flycat...
XP_007489460 330 PGPLPAEGRLDTAPYPLPRPS------------SQPAAteaaPAGPTDP--FLETLTLLVRRVLGPPPSPG---PLRL-- 390 gray short-tail...
XP_007658143 365 ARALPARGKLDVVPYPLPRPP------------TELREaaatPTPPPDSnhFLEALTHLVRGALAFPAPLPglaRLRL-- 430 platypus
XP_009294509 260 -----------------------------prlkHHRIPqderLPSRTYL--FLCELQKFLRDIL------PqskSTTPqd 302 zebrafish
1_pfamImport 187 -------------------------------tdtrYHQnsspASSQTs---FLCELKRFLGDVL------PqdlRESS-- 224
XP_013130583 236 -------------------------------tdtrCASgsppASLQTs---FLCEMKRFLGAVL------PqehFTSP-- 273 Nile tilapia
ABG24272     219 -----------------------------ingsRPAAFgssgVPVQTs---FVCELRRFLEGVL------PqdqDKQP-- 258 Japanese medaka
XP_029684643 226 --------------------------------------sdtrVAWQTSS--FLCELKQFLAGVT------PhshPESP-- 257 torafugu
CCP19123     353 SSFPHAHNPQALSAFDFRLPPekvkkdspveviVDHLHaphsTHRTTHE--FLRHLKSFLSSVLDDPVDHQs--TPML-- 426 Menado coelacanth
XP_023620423 273 PTPMPAHGRLDTLPFPSPSPT------------PEPEE----PLPGTDP--FLETLTRLVRTLRGPQARAS---PPRL-- 329 little brown bat
XP_005060059 410 ---WLDFEVMETLPHQLLNLSEEAA-LERLVQSEEPSVLLLp-----QDSGAVLEQ-HLGDWQPegTVLQLLTGKLQLLI 479 Collared flycat...
XP_007489460 391 ---ALDPEALEALPHQVFNLSDPAT-LEQLVESEDPLLLLFp-----AGSPALLDG-LAGWWQAqeGPAQRLAGKLQAVA 460 gray short-tail...
XP_007658143 431 ---DLDPVALEGLPQRFFNLSEPAT-LEQLVESEEPLLLRFp-----AGSRALLED-QAGHWRPeeGLARRLSAKLQGVA 500 platypus
XP_009294509 303 dpsAVSLDTLHSLPPLRLGVSSTESlLSGLVNSSTPTVFVF------PQRQQGLQT-HRVEVTLdsPLLSVLRMRLDEAM 375 zebrafish
1_pfamImport 225 ---PLQLDSLKSLPPLTLGPSSSDTlLAGLINSSSITVFSF------RSRASGFQV-HSGELAFspELLEELRRRLEAEV 294
XP_013130583 274 ---PLPLDSLQSLPPLSLGLSSSETlLAVMINSTAPTVFGF------TSWGSVLPV-CHGELALsaALLEELRQRLDQTL 343 Nile tilapia
ABG24272     259 ---LLQLDSLQALPPLPLGLSSSETlLAALINSSAPTIFYF------NNWGSKSQG-LRGQLILspALLVELRLRLEQSE 328 Japanese medaka
XP_029684643 258 ---LLQLSSLQSLPPLTLGRSTSEAtLAALIHSPSLTVLSF------GGCCSSSQV-HRGELALppPLSEELRQKLEQTV 327 torafugu
CCP19123     427 ---HLSKETVETLP------------------------------------------------------------------ 437 Menado coelacanth
XP_023620423 330 ---ALDPAALAGFPQGLVNLSDPVA-LERLLDGEEPLLLLLppaaatTGDPTPLQGpESSPWAA--DLARRVAAELQAAA 403 little brown bat
XP_005060059 480 QELRDI---PAFQANAA-LFQHLLGFCYFPAEpgqagpaERGrd------pRKLRTLLLLKALQSVRARWQEHR 543 Collared flycatcher
XP_007489460 461 KELLKM---PALQPHAE-LLRQLLAFCPAPTN-------SSGepae--apaSPLRALLLLKALQSLKAEWRERR 521 gray short-tailed opo...
XP_007658143 501 AELLEL---PALQPQAE-LLQRLLDFCQGVSNgtgrgggGGNnrtgaphppPQLHALLLLKALQSLRAEWQERR 570 platypus
XP_009294509 376 AQVKQ----QEAGRKMIdRLQKLTELSALSPDg------EDSeaatkdhkeAQYRSVLLLKALQMVLSNWESER 439 zebrafish
1_pfamImport 295 VKITAVmreEQVGRGATeRLGRLRELSALPmmep-------------apggRQYRAFLLLKALQTAARAYEAQR 355
XP_013130583 344 VQMTEIireEEVSLGAKeSLGRLKELSALQekeh-------------atggSQFRVFLLLKALQTVAQTYDAQR 404 Nile tilapia
ABG24272     329 MLILDLaeqETVSPRTTaRLERLKDLSASQQM-------EAAe--------SHFCAFLLLKALKTVAHAYDMTR 387 Japanese medaka
XP_029684643 328 THITEVi-rEEVGDEAIrRLGRLVELSAFPrkdl-------------atgqSQYRAFLLLKALQTVSRTYTVKR 387 torafugu
CCP19123         --------------------------------------------------------------------------     Menado coelacanth
XP_023620423 404 AELRGL---PGLPPAAPpLLARLLALCPGDSG-------DPG---------GPGRHC--AHCF-CYRrcsvcap 455 little brown bat
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