Conserved Protein Domain Family
Zfx_Zfy_act

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pfam04704: Zfx_Zfy_act 
Zfx / Zfy transcription activation region
Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.
Statistics
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PSSM-Id: 398398
Aligned: 11 rows
Threshold Bit Score: 354.906
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q95LI3         71 NVVIEDVQCSDIlEEADVS--ENVIIPEQMLSSDVT--------EEVSLahctvPDDVLASDITSASMSMPEHVLTSESV 140  cattle
XP_006632917   65 GLEAEVVEGPEI-GQGDVVtaDGVIVPESVLGAEVA--------IEEALd---aDHHVLTTDLIAESVRVPDQVFVADLV 132  spotted gar
XP_007228472   65 GLEAEVVEGPDI-GHEDVItaEGVIMSESILEAEVA--------IEEALd---aDHHVLTTDLIEETV--PDQVFVADLM 130  Mexican tetra
5_pfamImport    1 -LQSQGVEAHEItTEDMVSseHSVIMPDNILGSEVA--------IEDDLd------pILTSDLIQVS-DMPDQVFVAELL 64  
XP_007507473  295 GLASEVVQGPDIvTENDFVt-DGVFVPESVLEADIA--------IEEILg---iSDHILTSDLITETVRLPNQIFVADLV 362  gray short-ta...
XP_003218933   71 DVVIEDVQCPDImEDTDVS--QTVIIPETVLDSVVT--------EEVSLahcnvPDDVLSSEITPSTMSVPEQVLTNESL 140  green anole
P20662         68 NVLIEDVHCSHIlEETDIS--DNVIIPEQVLDLDTA--------EEVSLaqfliPD-ILTSSITSTSLTMPEHVLMSEAI 136  house mouse
XP_002935227   71 DVVIEDVQCSDIlDGARVS--EAVIIPEQVLEDEVGtgdeeqvlEDDSLtscdvPDNVLDSELVDGELTIPDSETGVHSV 148  tropical claw...
XP_005998519   75 DVVTDDVNCHNLmAETDVS--ETVIIPEQVLDMDVA--------TEVSLahctvPEDVLASDITAETMTIPEHVLTGESI 144  coelacanth
NP_001161471   65 DLSNEVVQGPDIiTEADVVt-ESVIVPEAVLETDVA--------IEQALd---dSHHVLESDIITETVAVPEQVFVADLV 132  tropical claw...
XP_005045771   65 GLAAEVVQGPDIiAETDVVt-EGVIVPDSVLEADVA--------IEEALd---sGDHVLTSDLITETVRVPEQVFVADLV 132  collared flyc...
Q95LI3        141 HVSDvGHVEHivhgsvvea--eivtdpltaDVVSEEVLVADCASEAVIDA-------NGIPVDQ---QDDD----KGNCE 204  cattle
XP_006632917  133 SHQD-GHLGH--------------------EMVSEEVMVTNSDSETVIQAheg-vpaSTVTIKT---EDDEd--gKSTSE 185  spotted gar
XP_007228472  131 SAHE--NLDH--------------------ELVSEEVMVT--DTEAVIQAhet--mpSSVTLKNddeDDDDdedgKSTSE 184  Mexican tetra
5_pfamImport   65 SEHQdNTLDH--------------------QLVSEGLMVAEANSENIIHQql---psETVTLQT---DEDDd--aRSSSE 116 
XP_007507473  363 TGPE-GHLEHvgqdsv--------sgadspTIVSEEVLVTNSDTEAVIQAast-lpgSTVALKT---EDDDd--gKSTSE 427  gray short-ta...
XP_003218933  141 HIPDvGHMEHvihdhnnvveseivtgslgeDVVSE-VLVADCASEAVIDA-------SGIPVE----HDED----KGNCE 204  green anole
P20662        137 HVSNvGHFEQvihdslver--eiitdpltaDI--SDILVADWASEAVLDS-------SGMPLEQ---QDDA----RINCE 198  house mouse
XP_002935227  149 S----GHvvgeeit----------ddaleeDMISEEVLVADCVSEAVIDA-------NGIPVHE---NDSE----EVNCD 200  tropical claw...
XP_005998519  145 HVPEvGHVEHvshavsete---ivadalstDVIPEEVLVTDCASEAVIDA-------NGIPIET---QEED----KGSCD 207  coelacanth
NP_001161471  133 TDRD-GQLEHvvqdsi--------hgshspTMVSQEVLVASCDADAVIQAptiqapgSSVTIKT---EDDEi---KNTSE 197  tropical claw...
XP_005045771  133 TGPE-GHLEHvvqdav--------aeaespTMVSEEVLVTNSDSEAVIQAagt-vpgSTVTIKT---EDDDd--gKSTSE 197  collared flyc...
Q95LI3        205 DYLMISLDD-DGKMEhDCSSGMTMDA---ESEI--DPCKVDGTCPEVIKVYIFKADpGEDDL--GGTVDIVESEPENDHG 276  cattle
XP_006632917  186 DYLMISLDDvGEKLD-IGNTPLKIST---EVTQd-DGSKEDGFGSEVIKVYIFKAE-AEDDVeiGGTEVVTESDFHNGHA 259  spotted gar
XP_007228472  185 DYLMISLDDvGEKLD-IGDTPLKITA---DVVQddDGSKEDEFGSEVIKVYIFKAE--DEDVeiGGTEVVAESDFPNGHA 258  Mexican tetra
5_pfamImport  117 DYLMISLDEvGEKLD-IGDTPLEMST---EVME--DKECKE----EVIKVYIFKAE-ADDDL--GGTEVITEDDYQNGHP 183 
XP_007507473  428 DYLMISLDEdAEKIDqIANPPVKINT---EASNd-DVTKEDEFGSEVIKVYIFKAE-AEDDVeiGGTEVVTDSDFHNGHS 502  gray short-ta...
XP_003218933  205 DYLMISLDE-AVKAEtDNSVDIKSDS---EG----DPCKMDGICPEVIKVYIFKADpGEDDI--GGTVDIVESESENDHG 274  green anole
P20662        199 DYLMMSLDE-PSKTDhEGSSEVTMNA---ESET--DSSKLDEASPEVIKVCILKADsEVDDV--GETIQAVESETDNGNE 270  house mouse
XP_002935227  201 DYLMISLDD-AEKIDeDGAEEITMRG---AVEG--DSSKLDGSCPEVIKVYIFKADpGEEDL--GGTVDIVESESENDHG 272  tropical claw...
XP_005998519  208 DYLMISLDD--AKIEhDGHAEITMEPeilEQGI--DSSKANGSCPEVIKVYIFKADpGDDDL--GGTVDIVESEMDNGVG 281  coelacanth
NP_001161471  198 DYLMISLDDvGEKLEhIGSTPLKIST---EVSQg-DMSKEDGFGSEVIKVYIFKAE-AEDDVeiGGTEIVTESDFHNGHP 272  tropical claw...
XP_005045771  198 DYLMISLDDvGEKLDhIGSTPLKIST---EVANd-DVAKDDGFGSEVIKVYIFKAE-AEDDVeiGGTEIVTESDFHNGHS 272  collared flyc...
Q95LI3        277 VEl--lDQNNSIRM--PREKMVYMTVNDSQQEDEDLNVAEIADEVYMEVIVGEEDAAVAaaaattvHEQEMDDSE--I-K 349  cattle
XP_006632917  260 VL----EPGSVGRL--PREKMVYMAVKDTSQEDEDINCAEIADEVYMEVIVGEEEAPAM-------QETQLDDST--VnK 324  spotted gar
XP_007228472  259 VL----ESASTGRL--PRDKMVYMAVKDTSQGDEETNVSEMTDQVYMEVIVGEDEAPAL-------QEAQLEDST--CnK 323  Mexican tetra
5_pfamImport  184 DL----EAASSGRLgvGRDKMVYMAVKNHTKEDMFLNVTCFSPFSLTDCVVRSQSQLYC-------QFLDVMQTGkgVeK 252 
XP_007507473  503 VPgvleQQGCVGRL--QREKMVYMAVKDSSHEGEDINCADIADEVYMEVIVGDEEAPAL-------PEAQVEDSG--VnK 571  gray short-ta...
XP_003218933  275 DTl--vNQNSSVRI--PREKMVYMAVNDSQHEDEELNVAEIADEVYMEVIVGEEDAAAA-------HEQPIDDNE--M-K 340  green anole
P20662        271 AEv--tDQRTSIHV--PRVN-IYMLASDSQKEEED-----------TKVIVGDEDAGGTaad-tpeHEQQMDVSE--IkA 331  house mouse
XP_002935227  273 DGf--lDSHNGGRM--PREKMVYMAVNDSQNDD-DLDVAEIADEVYMEVIVGEEDAAVA-------HEHQLEDAE--LsK 338  tropical claw...
XP_005998519  282 l----lEQGTTGRV--SREKMVYMTVNDSQQEDEELNVTDIADEVYMEVIVGEEEAAVA-------HEQQIDDTD--IsK 346  coelacanth
NP_001161471  273 VAgv-iEQSSLGRM--QREKMVYMAVKDSSQEDEEIGCAEIADEVYMEVIVGEEEAASL-------PDAQNEDSS--InK 340  tropical claw...
XP_005045771  273 VAgv-iEQGGVGRM--QREKMVYMAVKDSSQEDEDISCAEIADEVYMEVIVGEEEATSL-------PDTQLEDSG--VnK 340  collared flyc...
Q95LI3        350 TFMPIAWAAAY----------------GNNSD---GIENRSGTASALLHIDESAGLGRLTKHKPKKRRRPDSRQYQ 406  cattle
XP_006632917  325 TFVPVAWAAAY----------------GNNLDt--RLENKNGAATQYLQISDSISTSRALKQKAKKKKRGETRQCQ 382  spotted gar
XP_007228472  324 TFVPVAWAAAY----------------GNNLEs--RLESKNGTPTPYLQISDSISTSRALKQKIKKKRKGETRQCQ 381  Mexican tetra
5_pfamImport  253 TFLS---SLTY----------------KVNTDkydKVQVKNGAASPFLQIREGLSANRVLKPKLRKKKKGDTRQCQ 309 
XP_007507473  572 TFVPVAWAAAY----------------GNNLDt--RLENKDGTPAQYLQICDSVNTNKALKQKSKRRKRGESRLWQ 629  gray short-tailed...
XP_003218933  341 SFMPIAWAAAY----------------GNNTD---AVENRNGTASALLHIDESAGLGRLAKQKPRKRRRLESRQYQ 397  green anole
P20662        332 AFLPIAWTAAY----------------DNNSD---EIEVQNATASAMLHHDESGGLDRVPKQKSKKKKRPESKQYQ 388  house mouse
XP_002935227  339 TFMPVAWAAAY----------------GNNTD---GIEHRNGTASALLHIDESDGLDRLTKQKPKKKRRGENRQYQ 395  tropical clawed frog
XP_005998519  347 TFMPIAWAAAY----------------G--TD---GIENRNGTASALLHIDESASIEKLTKPRPKKRRRAESRQYQ 401  coelacanth
NP_001161471  341 TFVPVAWAAAYgedrdlprkygdwqesANNIEs--RLENKNSSATQYLQICDSIAANRALKQKAKKRKRGDARQWQ 414  tropical clawed frog
XP_005045771  341 TFVPVAWAAAYgderrlprryedgqaaGNNLDt--RLENKNGNATQYLQICDSISTNRVLKQKTKKRRRGEARQWQ 414  collared flycatcher
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