Conserved Protein Domain Family
Pinin_SDK_N
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pfam04697: Pinin_SDK_N 
pinin/SDK conserved region
SDK2/3 is localized in nuclear speckles where as pinin is known to localize at the desmosomes where it is thought to be involved in anchoring intermediate filaments to the desmosomal plaque. The role of SDK2/3 in the nucleus is thought to be concerned with modulation of alternative pre-mRNA splicing. pinin has also been implicated as a tumor suppressor. The conserved region is found at the N-terminus of the member proteins.
Links
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Statistics
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PSSM-Id: 398394
Aligned: 5 rows
Threshold Bit Score: 123.801
Threshold Setting Gi: 198428367
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEN66736       1 MAVAVRSLQDQINKAKENLKGVDENIKKLIGRDPSDNRPGAvggpGRRVSLggAGPGVGRGRGAGFRRESEDwg--dGPA 78  Florida lancelet
XP_004646406   1 MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQ----ARLLAL--SGPGGGRGRGSLLLRRGFSds-ggGPP 73  degu
NP_001166041   1 MAVAVRSLQDQLEKAKEGLKSVDENIRKLTGRDPGELRPGQ----NRRLTI--PGPGGGRGRGINLLRRGLSds-ggGPP 73  zebrafish
XP_011420191   3 evrgVSALQNEIEKARENLKGVDENIKKLTGRDPTERRQFA----PKRRVVsvSGELRGKERLFSQARREIEay---vsP 75  Pacific oyster
XP_002124629   1 MALAVSALKEQIERAKENLKTVDDSIKKVTGRDPNE---------A-RPERqmNERGRGRGRGQVLGRRRWTnegaeEPP 70  vase tunicate

EEN66736      79 VKRRgEIGlGAR------DRrvVTYRGRGRGRGRRDDEDDEDElPHKPSLASSV--IPTPTAKmTRKDSID 141 Florida lancelet
XP_004646406  74 AKQR-DLE-GAV------NR--LGGECRTRRESRQESDPEDDD-VKKPALQSSV--VATSKER-TRRDLIQ 130 degu
NP_001166041  74 AKLR-DID-GAL------LR--LAGDQRARRDSRHDSDAEDDDdVKKPALQSSV--VATSKER-TRRDLIQ 131 zebrafish
XP_011420191  76 VKRR-VVG-TAF------SR--LGPPRLAGRDRQRADSGDEEDlPNKPAVQSSVgnVITSKTPrSRKESMD 136 Pacific oyster
XP_002124629  71 SKKAgDLY-QRVgvgpgrRV--VAGNRRNFAPVAHHESEEEEEeEQKLTVQSSI--VSTAKKI-TKKELIH 135 vase tunicate
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