Conserved Protein Domain Family
Holin_SPP1

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pfam04688: Holin_SPP1 
SPP1 phage holin
This family constitutes holin proteins from the dsDNA Siphidoviridae group bacteriophages with two transmembrane segments. Most bacteriophages require an endolysin and a holin for host lysis. During late gene expression, holins accumulate and oligomerize in the host cell membrane. They then suddenly trigger to permeablise the membrane, which causes lysis by allowing endolysin to attach the peptidoglycan. There are thought to be at least 35 different families of holin genes.
Statistics
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PSSM-Id: 398388
Aligned: 21 rows
Threshold Bit Score: 66.189
Threshold Setting Gi: 504636220
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O31984         4 NIDKGT---IVRTLLLAIALLNQIM---VMLGKAAFIINEEdinhlydCLYTIFTIVFttstTTAAWFKNNYITAKG--- 74  Bacillus subtil...
Q5HMI0         3 KLDKGS---LVRGVLGLLAFLNVAL---ELSGHNPIPIDEG-------AINTFITLAFlgvtTILGYYKNFNVTQEAhva 69  Staphylococcus ...
YP_001504176   3 QNNTGKyapFIRLIVMGISFVATGLt--TIFGWEPLPFTDE-------QMNQGLMLVLsvglAIYNWYKNNAVTSYG--- 70  Enterococcus ph...
WP_012657417   1 -mDKMT---MIRTIILVYSLINSIL---VMLGFNPIPFTED-------EVGTAITLVLtvgaTLWSWWKNNNFTHEA--- 63  Macrococcus cas...
Q819I2         1 MLQKEN---LSDAMRLLAGFLLSLKllfTSFGIHFITNDQI----------DAIVNVVsflfILYFGYKNNYVGKKG--- 64  Bacillus cereus...
CDB19489       2 KVTKGT---IARTAILVLTIINSGL---AIFGKSPLPISDE-------TVTQVVSFGFstaaALVAWWKNNSFTVPA--- 65  Blautia sp. CAG:52
CDB50873       5 NMTAGT---LVRTVMLVVALLNLVL---TSFGKNPLPFSDE-------QIYTGLSALVtvaaALAAWWKNNSFTCCA--- 68  Clostridium sp....
CDB25270       5 KVSVET---VVRTIVLVVTLLNQVL---TMLGKNPLPFAED-------ELYSMLTAAAtvaaTLWAWWKNNSFTSAA--- 68  Oscillibacter s...
CDA20669       8 GVTAQT---WARTLVLVLALISQLA---VILGKRSEAIDID-------QWQEYVTYIFtvgaSIVAWWKNNSFTKNA--- 71  Ruminococcus sp...
CDA91621       8 GVSVQT---WARTIVLLLALISQLC---VILGKRSEAIDVD-------QWQEYATYILtvigSVWSWWNNNSFTEKA--- 71  Ruminococcus sp...
O31984        75 -------KKQKQVLKKE 84  Bacillus subtilis subsp. subtilis str. 168
Q5HMI0        70 qanlnalKQQKKYAQNT 86  Staphylococcus epidermidis RP62A
YP_001504176  71 -------KAKEEAGKEV 80  Enterococcus phage EF24C
WP_012657417  64 -------KEAQKHLLKM 73  Macrococcus caseolyticus
Q819I2        65 -------MEQKKILKKH 74  Bacillus cereus ATCC 14579
CDB19489      66 -------LKADAMMKET 75  Blautia sp. CAG:52
CDB50873      69 -------RQADEVLRVl 78  Clostridium sp. CAG:217
CDB25270      69 -------IQADEYMKEi 78  Oscillibacter sp. CAG:241
CDA20669      72 -------QVADDVknsp 81  Ruminococcus sp. CAG:488
CDA91621      72 -------QKADRIMKgd 81  Ruminococcus sp. CAG:563
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