Conserved Protein Domain Family
Tsg

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pfam04668: Tsg 
Twisted gastrulation (Tsg) protein conserved region
Tsg was identified in Drosophila as being required to specify the dorsal-most structures in the embryo, for example amnioserosa. Biochemical experiments have revealed three key properties of Tsg: it can synergistically inhibit Dpp/BMP action in both Drosophila and vertebrates by forming a tripartite complete between itself, SOG/chordin and a BMP ligand; Tsg seems to enhance the Tld/BMP-1-mediated cleavage rate of SOG/chordin and may change the preference of site utilisation; Tsg can promote the dissociation of chordin cysteine-rich-containing fragments from the ligand to inhibit BMP signalling.
Statistics
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PSSM-Id: 398376
Aligned: 32 rows
Threshold Bit Score: 110.841
Threshold Setting Gi: 390355202
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_794111     87 ASYSTINDLrmeSDWTDTLFNALTQVDKPHPd--sHWTvervtpqeegvnlpglv----------patpsegstsdvsps 154 purple sea urchin
4_pfamImport   1 ---STVAIF---DKPEPRLFVALTESSVPAL----RCSivrfpvsqelaahgsr------------elyhrrhhgkppev 58 
EEN49924      85 SSKSSISDL---TDPIPSLFKALT---DPSQdthlKWTimripadgdtpaisa-------------hhffhlidkslpdl 145 Florida lancelet
ELV12750      13 TSKSTVEEL---HEPIPSLFRALTEGDTQL-----NWNivsfpvaeelshhenl------------vsfletvnqphhqn 72  Chinese tree shrew
NP_571872     89 TSKSTVEEL---YRPIPSLFRALTEGDAPI-----NMMvvsfpvaeelshhen-------------lvsfletldsqsqn 147 zebrafish
Q98SR9        87 TGRSTVEDL---FQPIPSLFRALTEGDAPT-----HTLvltlplaeelqyqhnl-----------hnyletlhntqhnnt 147 zebrafish
XP_006012404  85 TSRSSVEDL---LVPIPSLFRALTTISDNDPp--mGWSvvsipvteelrhqhh-------------rhhimlgshkvael 146 coelacanth
Q5FVZ5       103 ARRSSLEEL---PVSVPSLFRAVSSMQEGESa--lGWTahnlpileelaqsth-------------mdhillgahsvvta 164 tropical clawed...
XP_003975395  90 TSRSTVEEL---HRPIPSLFRALTEGESPI-----NMMvvsfpiaeelshhen-------------lvsflesldnphqn 148 torafugu
XP_018672191  91 tMLSTVGHL---DEPEPRLFAALTDQPMPAL----RYTimrflslknlphtavesytnirkvsvlihyllgltlfmlgqp 163 vase tunicate
XP_794111    155 sKTAttaIS-------VNqtiv------pidiCTVAYIKICLGLEKCVDACHHMGAAKYRWFHTGCCECIGSSCLSYGKK 221 purple sea urchin
4_pfamImport  59 aQDIehtATkd-------------------piCVVMYFDECMSLNDCRMNCESTGSTSYRWFHNGCCECVGPDCLNHGHM 119
EEN49924     146 pVLTpphHNgtq------------------dlCTVVFFDDCMSDDKCKMSCESMGASRYRWFHNGCCQCIGPDCKNYGLN 207 Florida lancelet
ELV12750      73 vSVPsnnVHapyas-------------dkehmCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSK 139 Chinese tree shrew
NP_571872    148 iSLPtssAQdd-------------------alCTVVYFDDCVSIRQCKQYCESMGGSKYRWFHNACCECIGPECLDYGSK 208 zebrafish
Q98SR9       148 tSVPensIHssyht--------------qdkqCTVVYFDECVSIRQCKQYCESMGGSKYRWFHNACCQCIGPECVDYGSK 213 zebrafish
XP_006012404 147 lPGSsenSTa---------------------vCTVLYFHSCMSMNRCKQSCESLGASRYRWFHNACCECVGPDCHAYGSK 205 coelacanth
Q5FVZ5       165 sPLTnisGS-----------------------CTVLYFNPCMSMRRCHQSCESVGSPRYRWFHNGCCQCVGPDCHGYGSK 221 tropical clawed...
XP_003975395 149 vSVPgnsIH-------TSydaq-------enmCTVVYFDECVSIRQCKMYCESMGGSKYRWFHNACCQCIGPECVDYGSK 214 torafugu
XP_018672191 164 lEGAedrPSywegvglVLrrnydfdisdeslvCTVVYFDQCMALHDCRMSCSSTGALSYRWFHNGCCQCVGFNCLNYGST 243 vase tunicate
XP_794111    222 KALCSECP 229 purple sea urchin
4_pfamImport 120 EAKCSNCL 127
EEN49924     208 KVKCSNCM 215 Florida lancelet
ELV12750     140 TVKCMNCM 147 Chinese tree shrew
NP_571872    209 TVKCMNCL 216 zebrafish
Q98SR9       214 SVRCLNCL 221 zebrafish
XP_006012404 206 EAACQNCN 213 coelacanth
Q5FVZ5       222 EPLCLQCQ 229 tropical clawed frog
XP_003975395 215 AVKCMNCL 222 torafugu
XP_018672191 244 QPQCTDCM 251 vase tunicate
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