5XYR


Conserved Protein Domain Family
YSIRK_signal

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pfam04650: YSIRK_signal 
YSIRK type signal peptide
Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.
Statistics
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PSSM-Id: 398365
Aligned: 49 rows
Threshold Bit Score: 31.9637
Threshold Setting Gi: 530820006
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5XYR_A           3 KKQRFSLRKYKSGTFSVLIGSVFLV 27  
Q74LY6          17 KQERFSIRKFSVGAASVLVGTAVLt 41   Lactobacillus johnsonii
Q74HA8          25 RQDRFSIRKFSIGAVSVLIGSFIFc 49   Lactobacillus johnsonii
bgi:05SSU1922    8 KRQRFGIRKFTIGACSVLIGATLFG 32   Streptococcus suis 05ZYH33
Q74HU0           4 KKERFSIRKFSIGAASVLIGFTLFG 28   Lactobacillus johnsonii
bgi:05SSU0177    9 KEQRFSFRKFSFGLASAVIANVILG 33   Streptococcus suis 05ZYH33
bgi:05SSU1022    8 KRQRFGFRKMSVGLVSAAVTSLFFV 32   Streptococcus suis 05ZYH33
P14738           3 NNLRYGIRKHKLGAASVFLGTMIVV 27   Staphylococcus aureus subsp. aureus NCTC 8325
Q2G155           6 EERKYSIRKYSIGVVSVLAATMFVV 30   Staphylococcus aureus subsp. aureus NCTC 8325
Q5HKF8           6 ETRRFSIRKYTVGVVSIITGITIFV 30   Staphylococcus epidermidis RP62A
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