Conserved Protein Domain Family
ICA69

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pfam04629: ICA69 
Islet cell autoantigen ICA69, C-terminal domain
This family includes a 69 kD protein which has been identified as an islet cell autoantigen in type I diabetes mellitus. Its precise function is unknown.
Statistics
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PSSM-Id: 428043
Aligned: 18 rows
Threshold Bit Score: 218.496
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011604503 261 QYQFTTLKDLRDPLEEIADLTKQ---------EKTKENSPSNTD-SLVS--LDDDKHADAEPASNRDGqndtrahesiaa 328 torafugu
XP_008259909 260 PYEFTTLKSLQDPVKKLVEKEEKrk-----vaQQDSVEAPMQESsQLIS--LEDENQRTDSPGFQTED------------ 320 rabbit
XP_004767871 261 PYEFTTLKSLQDPMKKLIEKEERkk-----itQQESAEATVEEPrQLIS--LEDENQHKESSSFKTED------------ 321 domestic ferret
2_pfamImport   1 PYEFTMLKSLQDPVNKLTERAEKed------lQIESTKSVEDQQsQLIS--LDEESHTKESDYS---------------- 56 
XP_005041116 263 PYEFTMLKSLQDPVNKLTEKVERed------qQIESTNTVEDQQsQLIS--LDEESHTKESNYSADD------------- 321 Collared flycat...
5_pfamImport   1 PYEFTMLKNLQDPVNKLIEQATQne-----eaSADNSKEAAEQDdQLIS--LDENKGLADAPGN---------------- 57 
8_pfamImport   1 PYEFTTLKSLQDPANKLTDQGAKkksrrrikgKKDSRERSPDVDeQISStkLFQTTHSLSVSN----------------- 63 
XP_015213690 263 PYEFTTLKSLQDPANKLTDQGAKkksrrrikgKKDSRERSPDVDeQLIS--LDSEKHKEESSH----------------- 323 spotted gar
6_pfamImport   1 HYEFSTIKTLQDPVDKLAKKKG-------------KNKAKAETE------------------------------------ 31 
XP_005995472 259 PYEFTTLKNLQCPLDQLTE-------------DQEEKTVIDDVD-KLIL--LDDETLPESKLGTVIGDqn---------d 313 coelacanth
XP_011604503 329 pPAAMGSNDDQMLMDCDVpqfpqpvnaplqpqlplpppagdptesrgfeslpcslpplpgPSlstgtmLQTEEDVERGEM 408 torafugu
XP_008259909 321 -GKDVFSALDRSAMHSACsgpidglldmk---------------------seegagpgpgVG------TLDPEGADKDDL 372 rabbit
XP_004767871 322 -GKSVLSTLDKSSTHNACsdelldmkp------------------------eegaclgpmAG------TPEPDGADKDDL 370 domestic ferret
2_pfamImport  57 -GAIDdlldl---------------------------------------------qpeenASkdqfvrPLESEPGDKDDM 90 
XP_005041116 322 -GKDVISTLQGHCHHEQNsgaidall---------------------------dlqpeenASkekfvrSSEPEPGDKDDM 373 Collared flycat...
5_pfamImport  58 -SEISNKMSVPRILNSSSatsvddmld-------------------------lkpeekapAGtdlltdSVEPDANNKDEM 111
8_pfamImport  64 ---VAYTSCFlgvfkmqivrsqlsvlh------------------------lrpkvlqqtqtclpkqpSKSAEGSEKDEM 116
XP_015213690 324 ---TVHSASLHHSGEGFSpgfeevnlsgnqn----------------------------taqhdllsslpeqEGSEKDEM 372 spotted gar
6_pfamImport  32 ----------------------------------------------------------------------ESEAEEKDSM 41 
XP_005995472 314 iSCLSKDTEDCLFQSHDT------------------------------------------IPrdlladALQGEDPEKNDL 351 coelacanth
XP_011604503 409 AFLKDLLSPGVGANDEFSREWQDAFGVFEPSNTPQSTTESLNSGATAnppssSPTGFLPSQLLDHSLSSS-----GWSTP 483 torafugu
XP_008259909 373 LLLTEMFSASSLEEGEFGREWAAVFGDGRLRESAAAAGLGEPDLKLQ-----AGSSFLPSQLLDQNMKDLqaslkGWSES 447 rabbit
XP_004767871 371 LLLNEIFNASSLDEGEFSKEWAAVFGDDRLKEPVPTVAPGEPDPRPQ-----TGSGFLPSQLLDQNMKDLqaslqGWSES 445 domestic ferret
2_pfamImport  91 VLLNEILNASSLDEGEFSKEWTAVFGQVALNDLTMNSSAGDEETTSSsm-asTPSGYLPSQLLDQNMNDLqsslhGWAAN 169
XP_005041116 374 VLLNEILNASSLDEGEFSKEWTAVFGQ--AADLTMNSSARDGESTSSsa-vpAPSGYLPSQLLDQNMNDLqsslhGWAAS 450 Collared flycat...
5_pfamImport 112 TLINEILNTSSLEEDDFSREWKAVFGDDMLSSGATNPAAGEPDHVTS------SSGFLPSQLLDQNMNDLqssfsSWAAS 185
8_pfamImport 117 ALLSEILNSTSLEEGGFSQEWQAAFGEETLANSGAQPAAGEPVQEAS------SSGFLPSQLLDQNLNNLqssfaDWAMS 190
XP_015213690 373 ALLSEILNSTSLEEGGFSQEWQAAFGEETLANSGAQPAAGEPVQEAS------SSGFLPSQLLDQNLNNLqssfaDWAMS 446 spotted gar
6_pfamImport  42 ALLNEILGGLSVDEGDFSQEWTEVFGETEEGTSAASTRPTETQDK-------ENSFFLPSQLLDQSLNNLqssisDWA-- 112
XP_005995472 352 AFLNKLLNPGPSGTGDFSQEWQNAFGSLEPSPAALAPKNEIEQST-------KPAGFLPSQLLDLSLKTSge-fiNWTTP 423 coelacanth
XP_011604503 484 ---PMFqALPLQPPSGQNPSAel--aSGSTANAPPg-gSKDMSAWFNLFADLDPLSNPDAIGRSAD--ELLNA 548 torafugu
XP_008259909 448 svsPPP-PRPAPKTSCPNDNS-----RAVKEPAKA---ASDLTAWFSLFADLDPLSNPDAVGKTDKehELLNA 511 rabbit
XP_004767871 446 svsPPPtPWPAPQASSPNDNS-----PATKEPAKA---ASDLTAWFSLFADLDPLSNPDAVGKTDKehELLNA 510 domestic ferret
2_pfamImport 170 sgsPPSiPRPAQKPNSLNVNAn---kTPMKGEPTRn--PKDLTAWFSLFADLDPLSNPDAVGKTDKehELLNA 237
XP_005041116 451 svsPPSiPQPAQKPHSLNVNDg---kTPGKESTKN---PKDLTAWFSLFADLDPLSNPDAVGKTDKehELLNA 517 Collared flycatcher
5_pfamImport 186 nvnPQSiPLPAQQSDSLNQNVn---kTPVKGPLKN---SKDLSAWFNLFADLDPLSNPDAVGKTDKdhELLNA 252
8_pfamImport 191 nrqPAT--QALEQSGS-DQNIs---rPSVKGTPDTpqpAKDLSAWFNLFADLDPLSNPDAVGKTDKehELLNA 257
XP_015213690 447 nrqPAT--QALEQSGS-DQNIs---rPSVKDTPQP---AKDLSAWFNLFADLDPLSNPDAVGKTDKehELLNA 510 spotted gar
6_pfamImport 113 ---PHSaTQATEHSSEANQSTs---kPAEREAEGT---SKDLSAWFNLFADLDPLSNPDAIGKTNTehELHNA 176
XP_005995472 424 salPTq-SVPLHQPQSVPPQDvpeipPRVTKNNPP-----DMSPWFSLFADLDPLSNPDAIGRSDE--ELLNA 488 coelacanth
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