Conserved Protein Domain Family
ICA69

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pfam04629: ICA69 
Islet cell autoantigen ICA69, C-terminal domain
This family includes a 69 kD protein which has been identified as an islet cell autoantigen in type I diabetes mellitus. Its precise function is unknown.
Statistics
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PSSM-Id: 398355
Aligned: 20 rows
Threshold Bit Score: 173.798
Threshold Setting Gi: 198417847
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011604503 262 YQFTTLKDLRDPLEEIADLTKQ---------EKTKENSPSNTD-----------------SLVSLDDDKHADAEPASnrd 315 torafugu
Q28DQ1       264 YEFTTLKSLQDPVDKLIQQQEEee-----ekNKSKDDPAVKPDd----------------ELISLEDMKQATGSPGE--- 319 tropical clawed...
XP_008259909 261 YEFTTLKSLQDPVKKLVEKEEKrk-----vaQQDSVEAPMQESs----------------QLISLEDENQRTDSPGFqt- 318 rabbit
XP_004767871 262 YEFTTLKSLQDPMKKLIEKEERkk-----itQQESAEATVEEPr----------------QLISLEDENQHKESSSFkt- 319 domestic ferret
XP_005041116 264 YEFTMLKSLQDPVNKLTEKVERed------qQIESTNTVEDQQs----------------QLISLDEESHTKESNYSad- 320 Collared flycat...
XP_015214860 263 YEFTTLKDLRDPLEMLVNDPE----------KEKMENIQDDVDnfvfiknhahlralfnqTLILLDEEKPVGADSETaqs 332 spotted gar
XP_005995472 260 YEFTTLKNLQCPLDQLTE-------------DQEEKTVIDDVD-----------------KLILLDDETLPESKLGTvig 309 coelacanth
XP_015213690 264 YEFTTLKSLQDPANKLTDQGAKkksrrrikgKKDSRERSPDVDe----------------QLISLDSEKHKEESSH---- 323 spotted gar
XP_005465909 261 YQFTTLKDLRDPLEQISDSKKQe--------EKEKAALQSNTE-----------------SLLSLDDDNLSGSATDPdlp 315 Nile tilapia
XP_013038922 322 YEFTMLKSLQDPVNKLTERAEKed------lQIESTKSVEDQQs----------------QLISLDEESHTKESDYS--- 376 Anser cygnoides...
XP_011604503 316 gqndtrahesiaapPAAMGSNDDQMLMDCDVpqfpqpvnaplqpqlplpppagdptesrgfesLPCSLPPLPg------P 389 torafugu
Q28DQ1       320 --------------ANIGNLSSFEDILRENSvga---------------------------mdDLLDLKPDEkmfygetV 358 tropical clawed...
XP_008259909 319 ------------edGKDVFSALDRSAMHSACsgp---------------------------idGLLDMKSEEgagpgpgV 359 rabbit
XP_004767871 320 ------------edGKSVLSTLDKSSTHNACs------------------------------dELLDMKPEEgaclgpmA 357 domestic ferret
XP_005041116 321 -------------dGKDVISTLQGHCHHEQNsga---------------------------idALLDLQPEEn------A 354 Collared flycat...
XP_015214860 333 a---------dgqsKDTDSSLCASLNSGRPSdtaktlteaadd--------dllmildtlntpSSPTAPWSPvtqfcdmV 395 spotted gar
XP_005995472 310 d---------qndiSCLSKDTEDCLFQSHDT------------------------------------------------I 332 coelacanth
XP_015213690 324 ----------------TVHSASLHHSGEGFSpgfeevnls---------------gnqntaqhDLLSSLPEQ-------- 364 spotted gar
XP_005465909 316 lssd----gqrqtdDC------------DGSlhtggqp------------------------------------------ 337 Nile tilapia
XP_013038922 377 --------------GAID---------------------------------------------DLLDLQPEEn------A 391 Anser cygnoides...
XP_011604503 390 SLStgtmLQTEEDVERGEMAFLKDLLSPGVGANDEFSREWQDAFGVFEPSNTPQSTTESLNSGATAnpp--ssSPTGFLP 467 torafugu
Q28DQ1       359 PKD----PLDPDTGDKDEIQLLNDILSASSLEGDDLGKEWAAVFGDPLPNPHPVSPGATDMEQHAD-------SSAGFLP 427 tropical clawed...
XP_008259909 360 G------TLDPEGADKDDLLLLTEMFSASSLEEGEFGREWAAVFGDGRLRESAAAAGLGEPDLKLQ-------AGSSFLP 426 rabbit
XP_004767871 358 G------TPEPDGADKDDLLLLNEIFNASSLDEGEFSKEWAAVFGDDRLKEPVPTVAPGEPDPRPQ-------TGSGFLP 424 domestic ferret
XP_005041116 355 SKEkfvrSSEPEPGDKDDMVLLNEILNASSLDEGEFSKEWTAVFGQ--AADLTMNSSARDGESTSSsa---vpAPSGYLP 429 Collared flycat...
XP_015214860 396 PKDlladLPEGEDAERSDLSFLKDLLSPGPAGNEEFNREWHDAFGNFEASTASAPLPGPTAALSPDqp----sSPTGFLP 471 spotted gar
XP_005995472 333 PRDlladALQGEDPEKNDLAFLNKLLNPGPSGTGDFSQEWQNAFGSLEPSPAALAPKNEIEQST---------KPAGFLP 403 coelacanth
XP_015213690 365 -----------EGSEKDEMALLSEILNSTSLEEGGFSQEWQAAFGEETLANSGAQPAAGEPVQEAS--------SSGFLP 425 spotted gar
XP_005465909 338 hpagtnlRKEEDDGEPGDMAFLKDLLSPGSGASDEFSREWQDAFGMFTSPSVPTTSQGAQSGATAArppsnppSPTGFLP 417 Nile tilapia
XP_013038922 392 SKDqfvrPLESEPSDKDDMVLLNEILNASSLDEGEFSKEWTAVFGQVALTDLTMNSSAGDEENTSSsm---asTPSGYLP 468 Anser cygnoides...
XP_011604503 468 SQLLDHSLSSS-----GWSTP---PMFqaLPLQPPSGQNPSAe------LASGSTANAPPGGSKDMSAWFNLFADLDPLS 533 torafugu
Q28DQ1       428 SQLLDQDMNDLlsslhGWTANsgtSAS--QAAPPPSSLNSST-------NKAPAKDGSKNPGSKDLSAWYNLFADLDPLS 498 tropical clawed...
XP_008259909 427 SQLLDQNMKDLqaslkGWSESsvsPPPp-RPAPKTSCPNDNS---------RAVKEPAKA--ASDLTAWFSLFADLDPLS 494 rabbit
XP_004767871 425 SQLLDQNMKDLqaslqGWSESsvsPPPtpWPAPQASSPNDNS---------PATKEPAKA--ASDLTAWFSLFADLDPLS 493 domestic ferret
XP_005041116 430 SQLLDQNMNDLqsslhGWAASsvsPPSipQPAQKPHSLNVND-------GKTPGKESTKN--PKDLTAWFSLFADLDPLS 500 Collared flycat...
XP_015214860 472 SQLLDRSFSST-----GWATP---PMFqaQPLQTPQAPSQPVspptpppNAPKMTSKASKSSRRDMSAWFNLFADLDPLA 543 spotted gar
XP_005995472 404 SQLLDLSLKTSge-fiNWTTPsalPTq-sVPLHQPQSVPPQDvp----eIPPRVTKNNPP----DMSPWFSLFADLDPLS 473 coelacanth
XP_015213690 426 SQLLDQNLNNLqssfaDWAMSnrqPAT--QALEQSGS-DQNI-------SRPSVKDTPQP--AKDLSAWFNLFADLDPLS 493 spotted gar
XP_005465909 418 SQLLDHSLSST-----GWATP---PMFkaPPLQVPQSPNQSAq------PAPKSAGNAAPGGSKDMSAWFNLFADLDPLS 483 Nile tilapia
XP_013038922 469 SQLLDQNMNDLqsslhGWAANsgsPPSipQPAQKPNSLNVNA-------NKTPMKGEPTRN-PKDLTAWFSLFADLDPLS 540 Anser cygnoides...
XP_011604503 534 NPDAIGRSAD--ELLNA 548 torafugu
Q28DQ1       499 NPDAVGKTDKehELLNA 515 tropical clawed frog
XP_008259909 495 NPDAVGKTDKehELLNA 511 rabbit
XP_004767871 494 NPDAVGKTDKehELLNA 510 domestic ferret
XP_005041116 501 NPDAVGKTDKehELLNA 517 Collared flycatcher
XP_015214860 544 NPDAIGRSDD--ELLNA 558 spotted gar
XP_005995472 474 NPDAIGRSDE--ELLNA 488 coelacanth
XP_015213690 494 NPDAVGKTDKehELLNA 510 spotted gar
XP_005465909 484 NPDAIGRSAD--ELLNA 498 Nile tilapia
XP_013038922 541 NPDAVGKTDKehELLNA 557 Anser cygnoides domesticus
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