Conserved Protein Domain Family
ETS_PEA3_N

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pfam04621: ETS_PEA3_N 
PEA3 subfamily ETS-domain transcription factor N terminal domain
The N-terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.
Statistics
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PSSM-Id: 398352
Aligned: 31 rows
Threshold Bit Score: 231.896
Threshold Setting Gi: 260821692
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001315521   2 DGFYDQQVPFMVPPNQkslQVEEPYNRPVNDRKRklv-etEL--AQDTEELFQDLSQLQEIWIAEA-------------- 64  zebrafish
XP_001362921   7 GGYVDQQVPYTFSSk---sPGNGSLSRALMVTLGklmdpgSLp-PPESEDLFQDLSQFQETWLTEA-------------- 68  gray short-tail...
NP_001303294   7 GGYLDQRVPYTFCSk---sPGNGSLGEALMVPQGklmdpgSLp-PSDSEDLFQDLSHFQETWLAEA-------------- 68  house mouse
XP_007980197   2 DGFYDQQVPYMVTNSQ---RGRNCNEKPTNVRKRkfi-nrDL--AHDSEELFQDLSQLQETWLAEA-------------- 61  green monkey
XP_006636097   6 DGFYDQQVPYMITNNT---QGRKCNERPVNDRKRkfi-ntDL--AHDSEELFQDLSQLQETWLAEA-------------- 65  spotted gar
XP_017204328   7 GGYLDQQVPYTLCSk---sPGNGSLQEALMVPQGklmdpgSLp-PPDSEDLFQDLSHFQETWLAED-------------- 68  rabbit
XP_027301284   2 KGYLDQQVPFTFPQQPp--GHAGPGCGAPEGAGKspv-epGLppVQDSEDLFQDLSQFQETWLTEA-------------- 64  mallard
XP_029696752   6 DGYLDQQVPYTLANKS---HGNGPLNRLLMAAKRkym-etELp-PQESEDLFQDLSQLQETWLTEA-------------- 66  torafugu
TNN03300       6 DGYLDQQVPYTLANKS---HGNGPLNRLLMAAKRkym-etELp-PQESEDLFQDLSQLQETWLTEA-------------- 66  Takifugu bimacu...
XP_022524639   6 DGYLDQQVPYTLANRS---QGNGPLNRLLMAAKRkym-dtELp-PQESEDLFQDLSQLQETWLTEAqvpdsdeqfvpdfh 80  Mexican tetra
NP_001315521  65 ----Qvp---------------------dDEQ------FVPDFQSES-LmfhgPPlAKIKREL-SPSKEl-SPCSQDRS- 109 zebrafish
XP_001362921  69 ----Qvp--------------------dsDEQ------FVPDFHSEN-LafhsPT-TKIKKEPqSPRADptLSCSRKPPl 116 gray short-tail...
NP_001303294  69 ----Qvp--------------------dsDEQ------FVPDFHSEN-LafhsPT-TRIKKEPqSPRTDpaLSCSRKPPl 116 house mouse
XP_007980197  62 ----Qvp--------------------dnDEQ------FVPDYQAES-LafhgLP-LKIKKEPhSPCSEigSACSQEQPf 109 green monkey
XP_006636097  66 ----Qvp--------------------dnDEQ------FVPDFQAEN-LafhgLP-LKIKKEPqSPCSElsSTCTQEPSf 113 spotted gar
XP_017204328  69 ----AaagalspctspappqppllplptrSVT------PAAAGGDGG-VafhsPT-TRIKKEPqSPRTDpaLSCSRKPPl 136 rabbit
XP_027301284  65 ----Qvp--------------------dsDEQ------FVPDFHSEN-LafhsPP-AKIKKEPqSPSSDptLSCNHKQPf 112 mallard
XP_029696752  67 ----Qvp--------------------dsDEQ------FVPDFHSENsVafhsPP-VTIKKEPqSPGSDpsQSCSHKQSf 115 torafugu
TNN03300      67 ----Qvpd------------------sdeQFVpdfhseN-------S-VafhsPP-VTIKKEPqSPGSDpsQSCSHKQSf 115 Takifugu bimacu...
XP_022524639  81 sensVaf--------------------------------------------hsPP-VKIKKEPqSPGSDpsQSCSHKQSf 115 Mexican tetra
NP_001315521 110 PMPYGEKCLYSYSAYERKps-------tgFK--------------------------PLTPPSTP-VSPCVPSNALAtrp 155 zebrafish
XP_001362921 117 SYHHGEQCLY-TSAYDTPrq-------vaIK--------------------------SPTHS-APgQSPLQH-------- 153 gray short-tail...
NP_001303294 117 PYHHGEQCLY-SSAYDSPrq-------iaIK--------------------------SPAPG-APgQSPLQP-------- 153 house mouse
XP_007980197 110 KFSYGEKCLYNVSAYDQKpq-------vgMRps-----------------------nPPTPSSTP-VSPLHHAS------ 152 green monkey
XP_006636097 114 KFSYGEKCLYNvSAYDQKpq-------lgMKps-----------------------sPSTPCSTP-VSPLHHGS------ 156 spotted gar
XP_017204328 137 PYHHGEQCLYSs-AYDPPrq-------iaIK--------------------------SPAPG-APgQSPLQP-------- 173 rabbit
XP_027301284 113 QYRNGEQCLY-ASAYDQPrq-------vgIK--------------------------SPDPG-TPiQSPLQQ-------- 149 mallard
XP_029696752 116 SYPSGEQCLY-------AsayeqkrgaggAK--------------------------GSCPG-TP-MSPMQQHYSPK--- 157 torafugu
TNN03300     116 SYPSGEQCLY-ASAYEQKrga------ggAK--------------------------GSCPG-TP-MSPMQQHYSPK--- 157 Takifugu bimacu...
XP_022524639 116 SYPSGEQCLY-ASAYEQKra-------aaSAaastataaagagpgpgagpgagpgpkSSCPG-TP-MSPM-PHYSPK--- 181 Mexican tetra
NP_001315521 156 lheqtpppvsntalgqrllhgQPtmtkstpnqtcvphhSQSPPFVVPCP-----------PLN----R-ETHFSNEP--R 217 zebrafish
XP_001362921 154 ---------------------------------------------FPRAersfl--rppgAAPs---NpSHGFMMEPssI 183 gray short-tail...
NP_001303294 154 ---------------------------------------------FSRAeqqqsllrassSSQs---HpGHGYLGEHssV 185 house mouse
XP_007980197 153 ----------------------P------------------NSTHTPKPdrafp--ahlpPSQs---IpDSSYPMDH--R 185 green monkey
XP_006636097 157 ----------------------P------------------NPAPTPKPdrtyp--ahlpPSQq---MpDTSFPMDH--R 189 spotted gar
XP_017204328 174 ---------------------------------------------FPRTeqrsf-lrasgASQp---HpSHGYLGEHstP 204 rabbit
XP_027301284 150 ---------------------FP---------------RQDRSFLTPAGp---------pHPT----S-SCGYLIENssA 179 mallard
XP_029696752 158 ------------------------------------------PATAGRPdagym--nptaASQp---LpSNSFPINTssR 190 torafugu
TNN03300     158 ------------------------------------------PATAGRPdagym--nptaASQp--lP-SNSFPINTssR 190 Takifugu bimacu...
XP_022524639 182 ---------------------PP---------------------VGTRPetgym--nppsTSQshpsH-SHSFPINHssR 216 Mexican tetra
NP_001315521 218 F---QRQLSE-PCLPFPPSDAqgrpsfmpqvactSPRD--GRP-P--------------------------YH--RQ--- 259 zebrafish
XP_001362921 184 F---QQPPE--ICHSFPSSQG-------------GGRE--PPSaS--------------------------YQ--PQ--- 212 gray short-tail...
NP_001303294 186 F---QQPVD--MCHSFTSPQG-------------GGRE--PLPaP--------------------------YQ--HQ--- 214 house mouse
XP_007980197 186 F---RRQLSE-PCNSFPPLPT-------------MPRE--GRP-M--------------------------YQ--RQ--- 214 green monkey
XP_006636097 190 F---RRQLSE-PCRSFPTPSA-------------MTRD--GRP-I--------------------------YH--RQ--- 218 spotted gar
XP_017204328 205 SsvfQQPLD--MCHSFTSSQG-------------GGRE--TLPaP--------------------------YQ--HQ--- 236 rabbit
XP_027301284 180 Y---QPPVE--MCRSFPSSQG-------------MARE--APV-G--------------------------YQ--RQ--- 207 mallard
XP_029696752 191 Y---QGAAGEpMCSQFPPPAQ-------------PFQR--MPSaPaghggsgvgggggpggggggggggggYH--RQ--- 247 torafugu
TNN03300     191 Y---QGAAGEpMCSQFPPPAQ-------------PFQRmpSAP-A--------------------------GHggSGvgg 227 Takifugu bimacu...
XP_022524639 217 F---PAGSAE-MGPPFGPPGQ-------------ALQR--MHP-Apagggggg-----------gagggggYH--RQ--- 260 Mexican tetra
NP_001315521 260 --------------------MSEPLVPVPPQGFKQelldpryveq-------------gvpnmgpsqAA----------- 295 zebrafish
XP_001362921 213 --------------------LPEPCLPYPQQSFKReyhdplye----------------qagggggsAR----------- 245 gray short-tail...
NP_001303294 215 --------------------LSEPCPPYPQQNFKQeyhdplyeqag----------qpassqggvsgHR----------- 253 house mouse
XP_007980197 215 --------------------MSEPNIPFPPQGFKQeyhdpvyeh--------------ntmvgsaasQS----------- 249 green monkey
XP_006636097 219 --------------------MSEPSIPFPPQGFKQefpdpvyeh--------------namlgtpvaQN----------- 253 spotted gar
XP_017204328 237 --------------------LSEPCPPYPQQSFKQeyhdplyeqag----------qpavgqggvsgHR----------- 275 rabbit
XP_027301284 208 --------------------LSEPGLQYPPQGFKQeyhdprye----------------qasragssCQ----------- 240 mallard
XP_029696752 248 --------------------HSDPCMPYLQQSFKQeyldplyeraahmtgsgprsgpghgpgphphpHR----------- 296 torafugu
TNN03300     228 gggpggggggggggggyhrqHSDPCMPYLQQSFKQeyldplye-----------------raahmtgsGprsgpghgpgp 290 Takifugu bimacu...
XP_022524639 261 --------------------HSDPCMPYLQQSFKQefmdplyer--------------aahmagphpQR----------- 295 Mexican tetra
NP_001315521 296 ------FH--PMAIKQEPRDFCFDSEVPKCQSSFGRA-ASFYQNHEN----FSFDREqQLYFDDTCvVPERLE-GKVKQE 361 zebrafish
XP_001362921 246 ------YPgaGVVIKQEQTDFAYDSDVPGCQSMYLHAeGFPGPTPGEgtmgYGFEKSlRPFPEDVCvVPEKFE-GDIKQE 318 gray short-tail...
NP_001303294 254 ------YPgaGVVIKQERTDFAYDSDVPGCASMYLHPeGFSGPSPGDgvmgYGYEKSlRPFPDDVCiVPEKFE-GDIKQE 326 house mouse
XP_007980197 250 ------FPp-PLMIKQEPRDFAYDSEVPSCHSIYMRQeGFLAHPSRTe--gCMFEKGpRQFYDDTCvVPEKFD-GDIKQE 319 green monkey
XP_006636097 254 ------YPp-AMIIKQEPRDFTYDSEVPSCHSIYMRQeSFLAHSNRTe--gCIYDKVpRHFYDDTCvVPEKFE-GDIKQE 323 spotted gar
XP_017204328 276 ------YPgaGVVIKQEQTDFAYDSDVPGCASMYLHNeGFSGPSPGYg-----YEKPlRPFPDDVCvVPEKFE-GDMKQE 343 rabbit
XP_027301284 241 ------YPa-AVVVKQEQVDYVYDSg-------------------------CSYDKQmRSFSDDVCvVPEKFEaGDIKQE 288 mallard
XP_029696752 297 ------FPpaHMMVKQEPTDYTYDPDVPGCPSMYHRSeGYPNPPQHSnt-------egYLFENDSRvVPEKFE-GEVKQE 362 torafugu
TNN03300     291 hphphrFPpaHMMVKQEPTDYTYDPDVPGCPSMYHRTeGYPNPPQHS-------NTEgYLFENDSRvVPEKFE-GEVKQE 362 Takifugu bimacu...
XP_022524639 296 ------FPpaHMMVKQEPTDYTYEPDVPGCTSMYHHSeGYPNPQHNNe---------gYMFENDSRvVPEKFE-GEVKQE 359 Mexican tetra
NP_001315521 362 -PSVYREGPPYQRRG 375 zebrafish
XP_001362921 319 gLGTFREGPPYQRRG 333 gray short-tailed opossum
NP_001303294 327 gIGAFREGPPYQRRG 341 house mouse
XP_007980197 320 -PGMYREGPTYQRRG 333 green monkey
XP_006636097 324 -PGLYREGPTYQRRG 337 spotted gar
XP_017204328 344 gVGAFREGPPYQRRG 358 rabbit
XP_027301284 289 -VGGYREGPPYQRRG 302 mallard
XP_029696752 363 gGSVFREGTPYQRRG 377 torafugu
TNN03300     363 gGSVFREGTPYQRRG 377 Takifugu bimaculatus
XP_022524639 360 gGSVFREGAPYQRRG 374 Mexican tetra
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