3L9D,5F2V,6FGK


Conserved Protein Domain Family
RelA_SpoT
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pfam04607: RelA_SpoT 
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Region found in RelA / SpoT proteins
This region of unknown function is found in RelA and SpoT of Escherichia coli, and their homologs in plants and in other eubacteria. RelA is a guanosine 3',5'-bis-pyrophosphate (ppGpp) synthetase (EC:2.7.6.5) while SpoT is thought to be a bifunctional enzyme catalyzing both ppGpp synthesis and degradation (ppGpp 3'-pyrophosphohydrolase, (EC:3.1.7.2)). This region is often found in association with HD (pfam01966), a metal-dependent phosphohydrolase, TGS (pfam02824) which is a possible nucleotide-binding region, and the ACT regulatory domain (pfam01842).
Links
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Statistics
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PSSM-Id: 398342
Aligned: 91 rows
Threshold Bit Score: 87.6026
Threshold Setting Gi: 81767051
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3L9D_B  76 GRVKPIESIKEKMVLRGi------------KkenLTQDMQDIAGLRIMV--QF---------VDDVNDVLELLR----QR 128 Streptococcus mutans ...
Q9X388  65 SRVKDAGHLIDKIIRKTirekek-npdyyiDvnnYKSEITDLIGIRVLH--LY---------KDQAAPIDKFIR----DT 128 Bacillus anthracis
Q8G4H5 112 RRLKSVSSIIGKLERKGlp----------iGvnsIKDNLFDVAGIRVIC--NY---------RDDVYSVSNYLS----SQ 166 Bifidobacterium longum
Q8XKG7  50 TRVKSASSLKEKIIRHNyyi-------kydSptdLFRNLSDLIGVRIEC--RF---------IEDEEHIFKFIR----TI 107 Clostridium perfringens
Q898M4  66 SRVKSPKSLKEKIIRNNyyk-------kyeSseeLFENLSDLIGIRIEC--RF---------IEDENNIYEKIK----KN 123 Clostridium tetani
Q8FNX4  61 TRLKEWSSLKAKARKRGpdg--------alLypdPRRDIHDMIGVRITT--YH---------STEIPVALKVLR------ 115 Corynebacterium effic...
Q7MUI3  30 HRTKSVMSIKNKLERKAn------------EyreKNKKMQDLLALRITL--YF---------TDDVELIHNYLK----SQ 82  Porphyromonas gingivalis
Q889A5  52 SRIKDPGHLTEKVARKLadla------aepApeeMFRRLTDLSGVRVLLlhQYqfialhaefLKKTKNDWHLVEppkaYT 125 Pseudomonas syringae ...
Q8RF04  66 RRVKKPTHLIEKIIRKGkkyq-----erniSvlnYKEIVTDLIGIRVLH--LF---------KDDWQNIHHEIL----NL 125 Fusobacterium nucleat...
Q8XJZ8  66 SRIKNPDRLIEKIIRKTedrkekygedfyfNeynYKNEITDLIGIRVLH--IF---------KDQWKDIHDFII----KT 130 Clostridium perfringens

3L9D_B 129 KDMKVI-----QERDY-------------IN-NLkpSGYRSYHVIVeypv--dtiSGQRIIMAEIQIRTLAMNFWATIEH 187 Streptococcus mutans ...
Q9X388 129 WDLREKctiyyRQGDYskqeepknndlfnFKvHP--FGYRSWHYLIss------qATKNVHIAEIQVRTIFEEGWSEIDH 200 Bacillus anthracis
Q8G4H5 167 SDIQVL-----RVKDY-------------IK-NPkqNGYRSLHVIYavpv--flsSGAHYTPVEVQFRTIAMDYWASLEH 225 Bifidobacterium longum
Q8XKG7 108 FNCTNK-----DGFSYssqnpnifldlreHQpLKqkNGFELYRIDGfi------lNEEEKFNFELQIKSMVNNFWGEIEH 176 Clostridium perfringens
Q898M4 124 FHEKDE-----DGYYYnkinenikleltgEQpQQqrNGFEIFRIDGfy------eYGERKFNFELQIKSLVNIFWGEIEH 192 Clostridium tetani
Q8FNX4 116 -DSFIVhksvdKAKETr---------------ISggFGYGSHHLILevdetnedlQDYVGLVFEVQVRTVLQHAWAEFEH 179 Corynebacterium effic...
Q7MUI3  83 PNFDSEsvdeaEVDKFcpkrlnlvmrvpdILkQDmkAAIEETHY-----------KDLIDDTYEIQIRTILSEGWHEVEH 151 Porphyromonas gingivalis
Q889A5 126 WDPESA-----EFFKKl-----------dINtELkeSHYTSLHYVIr-------pKAESDVVCEIQVRTLFEEIWGEVDH 182 Pseudomonas syringae ...
Q8RF04 126 WDIKETpqvniRRGDYnlsqfketikdinCDvIVreHGYRSVHYLVgi-----diTKTLNISVEIQVRTVFEEAWSEIDH 200 Fusobacterium nucleat...
Q8XJZ8 131 WNVIEItanirDGDDRsifd------nlgIEvISrqSGYRSVHYLVel-----nfTQDSTTIAEIQVRTIFEEGYGEIDH 199 Clostridium perfringens

3L9D_B 188 SLNYKYHGE 196 Streptococcus mutans UA159
Q9X388 201 QLRYPNNMN 209 Bacillus anthracis
Q8G4H5 226 ALRYKTDLP 234 Bifidobacterium longum
Q8XKG7 177 KIIYKNYNM 185 Clostridium perfringens
Q898M4 193 KVIYKNNNY 201 Clostridium tetani
Q8FNX4 180 DIRYKRSGI 188 Corynebacterium efficiens
Q7MUI3 152 DLRYKCKEE 160 Porphyromonas gingivalis
Q889A5 183 SLNYPSPTD 191 Pseudomonas syringae pv. tomato
Q8RF04 201 IMRYPYDVD 209 Fusobacterium nucleatum subsp. nucleatum
Q8XJZ8 200 RLRYSHQEI 208 Clostridium perfringens
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