6N9N,6N9O


Conserved Protein Domain Family
Gasdermin

?
pfam04598: Gasdermin 
Click on image for an interactive view with Cn3D
Gasdermin family
The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein
Statistics
?
PSSM-Id: 398339
Aligned: 14 rows
Threshold Bit Score: 281.553
Threshold Setting Gi: 341940778
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6N9N_A         5 AFEKVVKNVIKEVSgSRGDLIPVDSLRNSTSFRPYCLLNRKFSSs-RFWK-PRYSCVNLSIKDILEPSA-PEPEPECFGS 81  house mouse
Q9Z2D3         1 MFAKATRNFLKEVD-AGGDLISVSHLNDSDKLQLLSLVTKKKRY--WCWQrPKYQILSATLEDVLTEGHcLSPVVVESDF 77  house mouse
XP_015136931   1 MFAKATRNFVRETD-SGGDLIPVSHLNASDKLQLLSLVTKRKKF--WCWQkPKYHFLAVSLSDVLTEDKpIKPVIVESDF 77  chicken
Q6J2R6         1 MFAKATKNLLSEID-SEGFLIPVLCLNDSDGLSPQALVIKRNRY--WFWQqPKYKPTDFKLSDVLVGDP-INPVVVETEF 76  zebrafish
Q29S10         4 AFEKVVRSVVRELD--HKDLTPVDSLWSSTSFQPYTLLSRKPLSs-RFWR-PRYKCVNLSIRDILEPDA-PEPALECGRT 78  cattle
6N9O_B         5 AFERVVRRVVQELD-HGGEFIPVTSLQSSTGFQPYCLVVRKPSSs-WFWK-PRYKCVNLSIKDILEPDA-AEPDVQRGRS 80  human
Q96QA5         3 MFENVTRALARQLN-PRGDLTPLDSLIDFKRFHPFCLVLRKRKSt-LFWG-ARYVRTDYTLLDVLEPGS-SPSDPTDTGN 78  human
Q32M21         3 MFEDVTRALARQLN-PRGDLTPLDSLIDFKRFHPFCLVLRKRKSt-LFWG-ARYVRTDYTLLDVLEPGS-SPSDPTLLGN 78  house mouse
Q2KJ26         4 LFEHTSKNLVKELG--DKDFRPLQNLLSAHKFCQLKLLRKKRRTlsQFWE-QPDVPVDHTLTDILEPSP-SVPEPVLSKK 79  cattle
Q9BYG8         4 MLERISKNLVKEIG--SKDLTPVKYLLSATKLRQFVILRKKKDSrsSFWEqSDYVPVEFSLNDILEPSS-SVLETVVTGP 80  human
6N9N_A        82 FKVSDVVDGNIQGRVMLSGM-GEGKISGGAAV-SDSSSASMNVCILRVTQKTWETmqhERHLQQPENKILQQLRSRG-DD 158 house mouse
Q9Z2D3        78 VKYESKCENHKSGAIGTVVGkVKLNVGGKGVVeSHSSFGTLRKQEVDVQQLIQDA---VKRTVNMDNLVLQQVLESRnEV 154 house mouse
XP_015136931  78 ARYMGKFEDVVQGSIETSFGkISLGAGAKGCVeSQSSFGSLRKQEVDLQQLMKDV---KDRMINLNSSLLQQVIERKrEV 154 chicken
Q6J2R6        77 LTYKGKVMDTKSGSAVAELGpGTINIGGSGSSkLQSSFGNLKKQELDLQKLLHDS---KSRVLDMQHSLIQQTRNAKtEV 153 zebrafish
Q29S10        79 FQFHDAMDGQLQGSVKLAAP-GQGRLSGGAAV-SGSSSASMDLCTLRVTPNTWEAmhhERRLRQPEPKTLQQLRSRG-DD 155 cattle
6N9O_B        81 FHFYDAMDGQIQGSVELAAP-GQAKIAGGAAV-SDSSSTSMNVYSLSVDPNTWQTllhERHLRQPEHKVLQQLRSRG-DN 157 human
Q96QA5        79 FGFKNMLDTRVEGDVDVP---KTVKVKGTA---GLSQNSTLEVQTLSVAPKALETv-qERKL-AADHPFLKEMQDQG-EN 149 human
Q32M21        79 FSFKNMLDVRVEGDVEVP---TMMKVKGTV---GLSQSSTLEVQMLSVAPTALENlhmERKL-SADHPFLKEMREYK-QN 150 house mouse
Q2KJ26        80 FIFIDKTVWKGAAEVDVTAG-LEVSVSGTA---TQSCECSLEVQSVTISPWDWEDl-qKRKVLDQEPSFLQECRTRG-DN 153 cattle
Q9BYG8        81 FHFSDIMIQKHKADMGVNVG-IEVSVSGEA---SVDHGCSLEFQIVTIPSPNLEDf-qKRKLLDPEPSFLKECRRRG-DN 154 human
6N9N_A       159 LFVVTEVLQTKEEVQITEVHSQEGSGQFTLPG-ALCLKGEGKGH------QSRKKMVTIPAGSILAFRVAQLLIGSK--W 229 house mouse
Q9Z2D3       155 LCVLTQKIMTTQKCVISEHVQSEETCGGMVGIqTKTIQVSATEDgt--vtTDTNVVLEIPAATTIAYGIMELFVKQDgqF 232 house mouse
XP_015136931 155 LCILREKIITTQRCTISEHIQTEEKVSGLLGCtTKIVKVSVSDSgs--mmKDSSVILEIPPATTIAYGVIELFIKCDgqF 232 chicken
Q6J2R6       154 LAVVKERIITTQPCTITEEVQEGGSCTGMFGF-NKTIKVSSNDKgkpsiaYDTDVSIDIPPKTTLAYSVIELDIAHTghY 232 zebrafish
Q29S10       156 VFVVTEVLQTQKEVEVTRTHKQEGSGQFALPG-AFCLQGKGEGH------LSQKKTVTIPSGSTLAFRAAQLVIGSD--W 226 cattle
6N9O_B       158 VYVVTEVLQTQKEVEVTRTHKREGSGRFSLPG-ATCLQGEGQGH------LSQKKTVTIPSGSTLAFRVAQLVIDSD--L 228 human
Q96QA5       150 LYVVMEVVETVQEVTLERAGKAEACFSLPFFA-PLGLQGS----------INHKEAVTIPKGCVLAFRVRQLMVKGKdeW 218 human
Q32M21       151 LYVVMEVVKAKQEVTLKRASNAISKFSLNLP--SLGLQGS----------VNHKEAVTIPKGCVLAYRVRQLIIYGKdeW 218 house mouse
Q2KJ26       154 LYVVTEAVKLVNETVLQDSSSVNATGTFSIPW-SFYAKSTAEGSg----lKERKRTMTVPQGTVMAYKKKQLVFREDgrA 228 cattle
Q9BYG8       155 LYVVTEAVELINNTVLYDSSSVNILGKIALW--ITYGKGQGQGEs----lRVKKKALTLQKGMVMAYKRKQLVIKEKa-- 226 human
6N9N_A       230 DILLVsDEKQRTFEP 244 house mouse
Q9Z2D3       233 EFCLL-QGKHGGFEH 246 house mouse
XP_015136931 233 EFCLL-DEQQGGFER 246 chicken
Q6J2R6       233 ELCLL-PAVKGGFEI 246 zebrafish
Q29S10       227 DILLFpDKKQRTFLS 241 cattle
6N9O_B       229 DVLLFpDKKQRTFQP 243 human
Q96QA5       219 DIPHIcNDNMQTFPP 233 human
Q32M21       219 GIPYIcTDNMPTFNP 233 house mouse
Q2KJ26       229 ILLISdDDKQKTFPE 243 cattle
Q9BYG8       227 -ILISdDDEQRTFQD 240 human
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap